Scope of a novel three-component synthesis of highly functionalized pyridines

被引：87
|
作者：
Dash, Jyotirmayee [1 ]
Lechel, Tilman [1 ]
Reissig, Hans-Ulrich [1 ]
机构：
[1] Free Univ Berlin, Inst Chem & Biochem, D-14195 Berlin, Germany
来源：
ORGANIC LETTERS | 2007年 / 9卷 / 26期
关键词：
D O I：
10.1021/ol702468s
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A mechanistically unique three-component synthesis provides a variety of functionalized pyridine derivatives in fair to excellent yields. The scope of this reaction was studied with respect to the alkoxyallene, the nitrile, and the carboxylic acid. Due to the 4-hydroxy group, these pyridine derivatives are suitable precursors for subsequent palladium-catalyzed reactions. Suzuki couplings of the corresponding pyridyl nonaflates lead to a variety of pyridine and bipyridine derivatives.
引用
收藏
页码：5541 / 5544
页数：4
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