High inflammatory activity and increase of interferon gamma and interleukin-12 levels in anaemic patients with debut of rheumatoid arthritis

被引：0
|
作者：
Herzog, OA [1 ]
Sennikov, SV [1 ]
Konenkova, LP [1 ]
Zonova, EV [1 ]
Korolev, MA [1 ]
Sizikov, AE [1 ]
Kozlov, VA [1 ]
机构：
[1] RAMS, SB, Inst Clin Immunol, Novosibirsk, Russia
来源：
IMMUNOLOGY 2004: AUTOIMMUNITY, GENETIC AND DEGENERATIVE DISORDERS, MALIGNANCIES, AND TRANSPLANTATION | 2004年
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D O I：
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中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Anaemia of chronic disease (ACD) is a common feature of active rheumatoid arthritis. The aim of this study was to compare anaemic and non anaemic patients with rheumatoid arthritis. All patients were not treated with disease-modifying antirheumatic drugs. The groups of anaemic patients and patients without anaemia were compared by clinical and laboratory parameters as well as by profile of cytokines. This study shows that anaemic patients with rheumatoid arthritis had higher inflammatory activity and that circulating levels of interferon gamma and interleukin-12 are significantly increased as compared with patients without anaemia and that the increased levels may be implicated in the pathogenesis of anemia in patients with rheumatoid arthritis.
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页码：75 / 78
页数：4
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