Mucosal Injury during Anti-Cancer Treatment: From Pathobiology to Bedside

被引：68
|
作者：
Basile, Debora [1 ,2 ]
Di Nardo, Paola [2 ]
Corvaja, Carla [1 ,2 ]
Garattini, Silvio Ken [1 ,2 ]
Pelizzari, Giacomo [1 ,2 ]
Lisanti, Camilla [1 ,2 ]
Bortot, Lucia [1 ,2 ]
Da Ros, Lucia [2 ]
Bartoletti, Michele [1 ,2 ]
Borghi, Matteo [3 ]
Gerratana, Lorenzo [1 ,2 ]
Lombardi, Davide [2 ]
Puglisi, Fabio [1 ,2 ]
机构：
[1] Univ Udine, Dept Med Dame, I-33100 Udine, Italy
[2] Ctr Riferimento Oncol Aviano CRO, IRCCS, Dept Med Oncol, I-33081 Aviano, Italy
[3] Ctr Riferimento Oncol Aviano CRO, IRCCS, Intens Care Unit, I-33081 Aviano, Italy
来源：
CANCERS | 2019年 / 11卷 / 06期
关键词：
mucosal injury; mucositis; mucosal impairment; anti-cancer treatments; INDUCED ORAL MUCOSITIS; STEM-CELL TRANSPLANTATION; METASTATIC BREAST-CANCER; LEVEL LASER THERAPY; 5-FLUOROURACIL-INDUCED INTESTINAL MUCOSITIS; CHEMOTHERAPY-INDUCED DIARRHEA; CLINICAL-PRACTICE GUIDELINES; ALIMENTARY-TRACT MUCOSITIS; PRO-INFLAMMATORY CYTOKINES; HELIUM-NEON LASER;
D O I：
10.3390/cancers11060857
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Mucositis is one of the most common debilitating side effects related to chemotherapy (CT), radiation therapy (RT), targeted agents and immunotherapy. It is a complex process potentially involving any portion of the gastrointestinal tract and injuring the mucosa, leading to inflammatory or ulcerative lesions. Mechanisms and clinical presentation can differ according both to the anatomic site involved (oral or gastrointestinal) and the treatment received. Understanding the pathophysiology and management of mucosal injury as a secondary effect of anti-cancer treatment is an important area of clinical research. Prophylaxis, early diagnosis, and adequate management of complications are essential to increase therapeutic success and, thus, improve the survival outcomes of cancer patients. This review focuses on the pathobiology and management guidelines for mucositis, a secondary effect of old and new anti-cancer treatments, highlighting recent advances in prevention and discussing future research options.
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页数：22
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