Prophylaxis with Sirolimus and Tacrolimus ± Antithymocyte Globulin Reduces the Risk of Acute Graft-versus-Host Disease without an Overall Survival Benefit Following Allogeneic Stem Cell Transplantation
被引:30
|
作者:
Rosenbeck, Lindsay L.
论文数: 0引用数: 0
h-index: 0
机构:
Indiana Univ Simon Canc Ctr, Indianapolis, IN 46202 USA
Indiana Univ Sch Med, Dept Pharm, Indianapolis, IN USAIndiana Univ Simon Canc Ctr, Indianapolis, IN 46202 USA
Rosenbeck, Lindsay L.
[1
,2
]
Kiel, Patrick J.
论文数: 0引用数: 0
h-index: 0
机构:
Indiana Univ Simon Canc Ctr, Indianapolis, IN 46202 USA
Indiana Univ Sch Med, Dept Pharm, Indianapolis, IN USAIndiana Univ Simon Canc Ctr, Indianapolis, IN 46202 USA
Kiel, Patrick J.
[1
,2
]
Kalsekar, Iftekhar
论文数: 0引用数: 0
h-index: 0
机构:
Butler Univ, Dept Pharm Practice, Indianapolis, IN 46208 USAIndiana Univ Simon Canc Ctr, Indianapolis, IN 46202 USA
Kalsekar, Iftekhar
[4
]
Vargo, Craig
论文数: 0引用数: 0
h-index: 0
机构:
Indiana Univ Sch Med, Dept Pharm, Indianapolis, IN USAIndiana Univ Simon Canc Ctr, Indianapolis, IN 46202 USA
Vargo, Craig
[2
]
Baute, John
论文数: 0引用数: 0
h-index: 0
机构:
Indiana Univ Simon Canc Ctr, Indianapolis, IN 46202 USAIndiana Univ Simon Canc Ctr, Indianapolis, IN 46202 USA
Baute, John
[1
]
Sullivan, Cheryl K.
论文数: 0引用数: 0
h-index: 0
机构:
Indiana Univ Simon Canc Ctr, Indianapolis, IN 46202 USAIndiana Univ Simon Canc Ctr, Indianapolis, IN 46202 USA
Sullivan, Cheryl K.
[1
]
Wood, Lisa
论文数: 0引用数: 0
h-index: 0
机构:
Indiana Univ Simon Canc Ctr, Indianapolis, IN 46202 USAIndiana Univ Simon Canc Ctr, Indianapolis, IN 46202 USA
Wood, Lisa
[1
]
Abdelqader, Sahar
论文数: 0引用数: 0
h-index: 0
机构:
Indiana Univ Simon Canc Ctr, Indianapolis, IN 46202 USAIndiana Univ Simon Canc Ctr, Indianapolis, IN 46202 USA
Abdelqader, Sahar
[1
]
Schwartz, Jennifer
论文数: 0引用数: 0
h-index: 0
机构:
Indiana Univ Simon Canc Ctr, Indianapolis, IN 46202 USA
Indiana Univ Sch Med, Dept Internal Med, Indianapolis, IN USAIndiana Univ Simon Canc Ctr, Indianapolis, IN 46202 USA
Schwartz, Jennifer
[1
,3
]
Srivastava, Shivani
论文数: 0引用数: 0
h-index: 0
机构:
Indiana Univ Simon Canc Ctr, Indianapolis, IN 46202 USA
Indiana Univ Sch Med, Dept Internal Med, Indianapolis, IN USAIndiana Univ Simon Canc Ctr, Indianapolis, IN 46202 USA
Srivastava, Shivani
[1
,3
]
Abonour, Rafat
论文数: 0引用数: 0
h-index: 0
机构:
Indiana Univ Simon Canc Ctr, Indianapolis, IN 46202 USA
Indiana Univ Sch Med, Dept Internal Med, Indianapolis, IN USAIndiana Univ Simon Canc Ctr, Indianapolis, IN 46202 USA
Abonour, Rafat
[1
,3
]
Robertson, Michael J.
论文数: 0引用数: 0
h-index: 0
机构:
Indiana Univ Simon Canc Ctr, Indianapolis, IN 46202 USA
Indiana Univ Sch Med, Dept Internal Med, Indianapolis, IN USAIndiana Univ Simon Canc Ctr, Indianapolis, IN 46202 USA
Robertson, Michael J.
[1
,3
]
Nelson, Robert P., Jr.
论文数: 0引用数: 0
h-index: 0
机构:
Indiana Univ Simon Canc Ctr, Indianapolis, IN 46202 USA
Indiana Univ Sch Med, Dept Internal Med, Indianapolis, IN USAIndiana Univ Simon Canc Ctr, Indianapolis, IN 46202 USA
Nelson, Robert P., Jr.
[1
,3
]
Cornetta, Kenneth
论文数: 0引用数: 0
h-index: 0
机构:
Indiana Univ Simon Canc Ctr, Indianapolis, IN 46202 USA
Indiana Univ Sch Med, Dept Internal Med, Indianapolis, IN USAIndiana Univ Simon Canc Ctr, Indianapolis, IN 46202 USA
Cornetta, Kenneth
[1
,3
]
Fausel, Christopher A.
论文数: 0引用数: 0
h-index: 0
机构:
Indiana Univ Simon Canc Ctr, Indianapolis, IN 46202 USA
Indiana Univ Sch Med, Dept Internal Med, Indianapolis, IN USAIndiana Univ Simon Canc Ctr, Indianapolis, IN 46202 USA
Fausel, Christopher A.
[1
,3
]
Farag, Sherif S.
论文数: 0引用数: 0
h-index: 0
机构:
Indiana Univ Simon Canc Ctr, Indianapolis, IN 46202 USA
Indiana Univ Sch Med, Dept Internal Med, Indianapolis, IN USAIndiana Univ Simon Canc Ctr, Indianapolis, IN 46202 USA
Farag, Sherif S.
[1
,3
]
机构:
[1] Indiana Univ Simon Canc Ctr, Indianapolis, IN 46202 USA
[2] Indiana Univ Sch Med, Dept Pharm, Indianapolis, IN USA
[3] Indiana Univ Sch Med, Dept Internal Med, Indianapolis, IN USA
[4] Butler Univ, Dept Pharm Practice, Indianapolis, IN 46208 USA
Methotrexate (MIX) is a standard agent used in combination with calcineurin inhibitors for graft-versus-host disease (GVHD) prophylaxis in patients undergoing allogeneic hematopoietic cell (HCT) transplantation. We retrospectively compared the incidence of acute GVHD (aGVHD), transplant-related morbidity, and mortality in patients given sirolimus/tacrolimus +/- antithymocyte globulin (ATG) versus MTX/tacrolimus or cyclosporine and allogeneic transplantation for hematologic malignancies. Between January 1, 2005, and April 30, 2009, 106 consecutive patients received peripheral blood HCT or bone marrow grafts after 1 of 6 myeloablative conditioning regimens. The incidence of grade II-IV aGVHD was 18.6% in patients who received sirolimus/tacrolimus compared to 48.9% who received MIX (P = .001). The incidence of grade III-IV aGVHD was 5% and 17% (P = .045), respectively. There was no difference in overall survival (OS) between the groups (P = .160). Chronic GVHD (cGVHD) occurred in 40.4% who received sirolimus and 41.9% receiving MIX (P = .89). The incidence of thrombotic microangiopathy or interstitial pneumonitis was not significantly different between groups. The reduction in the risk of severe aGVHD was offset by an increased (20% versus 4%, P = .015) incidence of and mortality from sinusoidal obstructive syndrome (SOS). Sirolimus/tacrolimus appears to reduce the incidence of aGVHD after conventional allotransplantion compared to MTX-calcineurin inhibitor prophylaxis; however, this did not improve survival. Biol Blood Marrow Transplant 17: 916-922 (2011) (C) 2011 American Society for Blood and Marrow Transplantation
机构:
Univ S Florida, H Lee Moffitt Canc Ctr, Blood & Marrow Transplantat, Tampa, FL 33682 USA
Univ S Florida, Morsani Coll Med, Dept Oncol Sci, Tampa, FL USAUniv S Florida, H Lee Moffitt Canc Ctr, Blood & Marrow Transplantat, Tampa, FL 33682 USA
Kharfan-Dabaja, Mohamed A.
Parody, Rocio
论文数: 0引用数: 0
h-index: 0
机构:
Hosp Univ Virgen del Rocio, Dept Hematol, Seville, SpainUniv S Florida, H Lee Moffitt Canc Ctr, Blood & Marrow Transplantat, Tampa, FL 33682 USA
Parody, Rocio
Perkins, Janelle
论文数: 0引用数: 0
h-index: 0
机构:
Univ S Florida, Coll Pharm, Tampa, FL USA
Univ S Florida, H Lee Moffitt Canc Ctr, Dept Blood & Marrow Transplantat, Tampa, FL 33682 USAUniv S Florida, H Lee Moffitt Canc Ctr, Blood & Marrow Transplantat, Tampa, FL 33682 USA
Perkins, Janelle
Lopez-Godino, Oriana
论文数: 0引用数: 0
h-index: 0
机构:
Hosp Univ Salamanca, Salamanca, SpainUniv S Florida, H Lee Moffitt Canc Ctr, Blood & Marrow Transplantat, Tampa, FL 33682 USA
Lopez-Godino, Oriana
Lopez-Corral, Lucia
论文数: 0引用数: 0
h-index: 0
机构:
Hosp Univ Salamanca, Salamanca, SpainUniv S Florida, H Lee Moffitt Canc Ctr, Blood & Marrow Transplantat, Tampa, FL 33682 USA
Lopez-Corral, Lucia
Vazquez, Lourdes
论文数: 0引用数: 0
h-index: 0
机构:
Hosp Univ Salamanca, Salamanca, SpainUniv S Florida, H Lee Moffitt Canc Ctr, Blood & Marrow Transplantat, Tampa, FL 33682 USA
Vazquez, Lourdes
Caballero, Dolores
论文数: 0引用数: 0
h-index: 0
机构:
Hosp Univ Salamanca, Salamanca, SpainUniv S Florida, H Lee Moffitt Canc Ctr, Blood & Marrow Transplantat, Tampa, FL 33682 USA
Caballero, Dolores
Falantes, Jose
论文数: 0引用数: 0
h-index: 0
机构:
Hosp Univ Virgen del Rocio, Dept Hematol, Seville, SpainUniv S Florida, H Lee Moffitt Canc Ctr, Blood & Marrow Transplantat, Tampa, FL 33682 USA
Falantes, Jose
Shapiro, Jamie
论文数: 0引用数: 0
h-index: 0
机构:
Univ S Florida, H Lee Moffitt Canc Ctr, Dept Pharm, Tampa, FL 33682 USAUniv S Florida, H Lee Moffitt Canc Ctr, Blood & Marrow Transplantat, Tampa, FL 33682 USA
Shapiro, Jamie
Orti, Guillermo
论文数: 0引用数: 0
h-index: 0
机构:
Hosp Univ ValldHebron, Barcelona, SpainUniv S Florida, H Lee Moffitt Canc Ctr, Blood & Marrow Transplantat, Tampa, FL 33682 USA
Orti, Guillermo
Barba, Pere
论文数: 0引用数: 0
h-index: 0
机构:
Hosp Univ ValldHebron, Barcelona, SpainUniv S Florida, H Lee Moffitt Canc Ctr, Blood & Marrow Transplantat, Tampa, FL 33682 USA
Barba, Pere
Valcarcel, David
论文数: 0引用数: 0
h-index: 0
机构:
Hosp Valle De Hebron, Barcelona, SpainUniv S Florida, H Lee Moffitt Canc Ctr, Blood & Marrow Transplantat, Tampa, FL 33682 USA
Valcarcel, David
Esquirol, Alber
论文数: 0引用数: 0
h-index: 0
机构:
Hosp Santa Creu & Sant Pau, Barcelona, SpainUniv S Florida, H Lee Moffitt Canc Ctr, Blood & Marrow Transplantat, Tampa, FL 33682 USA
Esquirol, Alber
Martino, Rodrigo
论文数: 0引用数: 0
h-index: 0
机构:
Hosp Santa Creu & Sant Pau, Barcelona, SpainUniv S Florida, H Lee Moffitt Canc Ctr, Blood & Marrow Transplantat, Tampa, FL 33682 USA
Martino, Rodrigo
Luis Pinana, Jose
论文数: 0引用数: 0
h-index: 0
机构:
Hosp Clin Valenci, Dept Hematol, Valencia, SpainUniv S Florida, H Lee Moffitt Canc Ctr, Blood & Marrow Transplantat, Tampa, FL 33682 USA
Luis Pinana, Jose
Solano, Carlos
论文数: 0引用数: 0
h-index: 0
机构:
Hosp Clin Valenci, Valencia, SpainUniv S Florida, H Lee Moffitt Canc Ctr, Blood & Marrow Transplantat, Tampa, FL 33682 USA
Solano, Carlos
Pidala, Joseph A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ S Florida, H Lee Moffitt Canc Ctr, Blood & Marrow Transplantat, Tampa, FL 33682 USAUniv S Florida, H Lee Moffitt Canc Ctr, Blood & Marrow Transplantat, Tampa, FL 33682 USA
Pidala, Joseph A.
Anasetti, Claudio
论文数: 0引用数: 0
h-index: 0
机构:
Univ S Florida, H Lee Moffitt Canc Ctr, Dept Blood & Marrow Transplantat, Tampa, FL 33682 USAUniv S Florida, H Lee Moffitt Canc Ctr, Blood & Marrow Transplantat, Tampa, FL 33682 USA
Anasetti, Claudio
Perez-Simon, Jose A.
论文数: 0引用数: 0
h-index: 0
机构:
Hosp Univ Virgen del Rocio, Dept Hematol, Seville, SpainUniv S Florida, H Lee Moffitt Canc Ctr, Blood & Marrow Transplantat, Tampa, FL 33682 USA
机构:
Wayne State Univ, Blood & Marrow Program, Karmanos Canc Ctr, Dept Oncol, Detroit, MI 48201 USAWayne State Univ, Blood & Marrow Program, Karmanos Canc Ctr, Dept Oncol, Detroit, MI 48201 USA
Al-Kadhimi, Zaid
Gul, Zartash
论文数: 0引用数: 0
h-index: 0
机构:
Univ Kentucky, Markey Canc Ctr, Div Hematol Bone Marrow Transplantat, Lexington, KY USAWayne State Univ, Blood & Marrow Program, Karmanos Canc Ctr, Dept Oncol, Detroit, MI 48201 USA
Gul, Zartash
Rodriguez, Roberto
论文数: 0引用数: 0
h-index: 0
机构:
Bone Marrow Transplant Program, So Calif Kaiser Permanente, City Hope Natl Med Ctr So, Duarte, CA USAWayne State Univ, Blood & Marrow Program, Karmanos Canc Ctr, Dept Oncol, Detroit, MI 48201 USA
Rodriguez, Roberto
Chen, Wei
论文数: 0引用数: 0
h-index: 0
机构:
Wayne State Univ, Biostat Core, Karmanos Canc Ctr, Dept Oncol, Detroit, MI 48201 USAWayne State Univ, Blood & Marrow Program, Karmanos Canc Ctr, Dept Oncol, Detroit, MI 48201 USA
Chen, Wei
Smith, Daryn
论文数: 0引用数: 0
h-index: 0
机构:
Wayne State Univ, Biostat Core, Karmanos Canc Ctr, Dept Oncol, Detroit, MI 48201 USAWayne State Univ, Blood & Marrow Program, Karmanos Canc Ctr, Dept Oncol, Detroit, MI 48201 USA
Smith, Daryn
Mitchell, Alice
论文数: 0引用数: 0
h-index: 0
机构:
Wayne State Univ, Clin Trials Off, Karmanos Canc Ctr, Detroit, MI 48201 USAWayne State Univ, Blood & Marrow Program, Karmanos Canc Ctr, Dept Oncol, Detroit, MI 48201 USA
Mitchell, Alice
论文数: 引用数:
h-index:
机构:
Abidi, Muneer
Ayash, Lois
论文数: 0引用数: 0
h-index: 0
机构:
Wayne State Univ, Blood & Marrow Program, Karmanos Canc Ctr, Dept Oncol, Detroit, MI 48201 USAWayne State Univ, Blood & Marrow Program, Karmanos Canc Ctr, Dept Oncol, Detroit, MI 48201 USA
Ayash, Lois
Deol, Abhinav
论文数: 0引用数: 0
h-index: 0
机构:
Wayne State Univ, Blood & Marrow Program, Karmanos Canc Ctr, Dept Oncol, Detroit, MI 48201 USAWayne State Univ, Blood & Marrow Program, Karmanos Canc Ctr, Dept Oncol, Detroit, MI 48201 USA
Deol, Abhinav
Lum, Lawrence
论文数: 0引用数: 0
h-index: 0
机构:
Wayne State Univ, Blood & Marrow Program, Karmanos Canc Ctr, Dept Oncol, Detroit, MI 48201 USA
Wayne State Univ, Dept Immunol & Microbiol, Detroit, MI 48201 USAWayne State Univ, Blood & Marrow Program, Karmanos Canc Ctr, Dept Oncol, Detroit, MI 48201 USA
Lum, Lawrence
Forman, Stephen
论文数: 0引用数: 0
h-index: 0
机构:
Bone Marrow Transplant Program, So Calif Kaiser Permanente, City Hope Natl Med Ctr So, Duarte, CA USAWayne State Univ, Blood & Marrow Program, Karmanos Canc Ctr, Dept Oncol, Detroit, MI 48201 USA
Forman, Stephen
Ratanatharathorn, Voravit
论文数: 0引用数: 0
h-index: 0
机构:
Wayne State Univ, Blood & Marrow Program, Karmanos Canc Ctr, Dept Oncol, Detroit, MI 48201 USAWayne State Univ, Blood & Marrow Program, Karmanos Canc Ctr, Dept Oncol, Detroit, MI 48201 USA
Ratanatharathorn, Voravit
Uberti, Joseph
论文数: 0引用数: 0
h-index: 0
机构:
Wayne State Univ, Blood & Marrow Program, Karmanos Canc Ctr, Dept Oncol, Detroit, MI 48201 USAWayne State Univ, Blood & Marrow Program, Karmanos Canc Ctr, Dept Oncol, Detroit, MI 48201 USA