A fluorogenic H2S-triggered prodrug based on thiolysis of the NBD amine

被引：4
|
作者：
Xie, Yonghui [1 ,2 ]
Huang, Haojie [3 ,4 ]
Ismail, Ismail [1 ,2 ]
Sun, Hongyan [5 ,6 ,7 ]
Yi, Long [3 ,4 ,8 ]
Xi, Zhen [1 ,2 ,8 ]
机构：
[1] Nankai Univ, State Key Lab Elementoorgan Chem, Natl Engn Res Ctr Pesticide Tianjin, Coll Chem, Tianjin 300071, Peoples R China
[2] Nankai Univ, Dept Chem Biol, Natl Engn Res Ctr Pesticide Tianjin, Coll Chem, Tianjin 300071, Peoples R China
[3] Beijing Univ Chem Technol, State Key Lab Organ Inorgan Composites, Beijing 100029, Peoples R China
[4] Beijing Univ Chem Technol, Beijing Key Lab Bioproc, Beijing 100029, Peoples R China
[5] City Univ Hong Kong, Dept Chem, Kowloon, 83 Tat Chee Ave, Hong Kong, Peoples R China
[6] City Univ Hong Kong, Ctr Super Diamond & Adv Films COSDAF, Kowloon, 83 Tat Chee Ave, Hong Kong, Peoples R China
[7] City Univ Hong Kong, Shenzhen Res Inst, Biotech & Hlth Ctr, Key Lab Biochip Technol, Shenzhen 518057, Peoples R China
[8] Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin, Peoples R China
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2019年 / 29卷 / 19期
关键词：
Prodrug; H2S-triggered; Ciprofloxacin; NBD amine; HYDROGEN-SULFIDE; FLUORESCENT-PROBE; SENSITIVE DETECTION; DRUG-DELIVERY; H2S SYNTHESIS; CANCER-CELLS; INHIBITION; AUTOPHAGY; SPECTRA;
D O I：
10.1016/j.bmcl.2019.126627
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Based on thiolysis of the NBD amine, a H2S-triggered prodrug has been designed and synthesized for localized production of ciprofloxacin under micromolar H2S. Activation of the prodrug can be monitored through fluorescence in real-time. We envision that thiolysis of the NBD amine could be readily used for development of other H2S-triggered prodrugs in the future.
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收藏
页数：4
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