Alcoholic liver disease and the gut-liver axis

被引：268

作者：

Szabo, Gyongyi ^{[1
]}

Bala, Shashi ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Dept Med, Ctr Liver, Worcester, MA 01605 USA

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2010年 / 16卷 / 11期

关键词：

Kupffer cell; Gut permeability; microRNA; Tumor necrosis factor-alpha; Endotoxin; LIPOPOLYSACCHARIDE-BINDING-PROTEIN; TUMOR-NECROSIS-FACTOR; CACO-2 CELL MONOLAYER; TOLL-LIKE RECEPTOR-4; TNF-ALPHA PRODUCTION; RAT KUPFFER CELLS; NF-KAPPA-B; HEPATIC NEUTROPHIL INFILTRATION; ACETALDEHYDE-INDUCED INCREASE; GRAM-NEGATIVE BACTERIA;

D O I：

10.3748/wjg.v16.i11.1321

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Alcoholic liver disease (ALD) is one of the leading causes of liver diseases and liver-related death worldwide. Of the many factors that contribute to the pathogenesis of ALD, gut-derived lipopolysaccharide (LPS) plays a central role in induction of steatosis, inflammation, and fibrosis in the liver. In this review, we discuss the mechanisms by which alcohol contributes to increased gut permeability, the activation of Kupffer cells, and the inflammatory cascade by LPS. The role of the Toll-like receptor 4 (TLR4) complex in LPS recognition and the importance of the TLR4-induced signaling pathways are evaluated in ALD. (C) 2010 Baishideng. All rights reserved.

引用

页码：1321 / 1329

页数：9

共 50 条

[1] Alcoholic liver disease and the gut-liver axis
Gyongyi Szabo
Shashi Bala
[J]. World Journal of Gastroenterology, 2010, 16 (11) : 1321 - 1329
[2] Gut-Liver Axis in Alcoholic Liver Disease
Szabo, Gyongyi
[J]. GASTROENTEROLOGY, 2015, 148 (01) : 30 - 36
[3] Gut-liver axis and sterile signals in the development of alcoholic liver disease
Szabo, Gyongyi
Petrasek, Jan
[J]. ALCOHOL AND ALCOHOLISM, 2017, 52 (04): : 414 - 424
[4] Gut-liver axis: PPls, Enterococcus and promotion of alcoholic liver disease
Ray, Katrina
[J]. NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, 2017, 14 (12) : 689 - 689
[5] Gut-liver axis: The impact of gut microbiota on non alcoholic fatty liver disease
Compare, D.
Coccoli, P.
Rocco, A.
Nardone, O. M.
De Maria, S.
Carteni, M.
Nardone, G.
[J]. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, 2012, 22 (06) : 471 - 476
[6] Gut-liver axis, nutrition, and non-alcoholic fatty liver disease
Kirpich, Irina A.
Marsano, Luis S.
McClain, Craig J.
[J]. CLINICAL BIOCHEMISTRY, 2015, 48 (13-14) : 923 - 930
[7] Gut-liver axis alterations in alcoholic liver disease: Are bile acids the answer?
Bajaj, Jasmohan S.
Hylemon, Phillip B.
[J]. HEPATOLOGY, 2018, 67 (06) : 2074 - 2075
[8] Gut-Liver Axis Derangement in Non-Alcoholic Fatty Liver Disease
Poeta, Marco
Pierri, Luca
Vajro, Pietro
[J]. CHILDREN-BASEL, 2017, 4 (08):
[9] Targeting the gut-liver axis in liver disease
Wiest, Reiner
Albillos, Agustin
Trauner, Michael
Bajaj, Jasmohan S.
Jalan, Rajiv
[J]. JOURNAL OF HEPATOLOGY, 2017, 67 (05) : 1084 - 1103
[10] Gut-liver axis and probiotics: Their role in non-alcoholic fatty liver disease
Paolella, Giulia
Mandato, Claudia
Pierri, Luca
Poeta, Marco
Di Stasi, Martina
Vajro, Pietro
[J]. WORLD JOURNAL OF GASTROENTEROLOGY, 2014, 20 (42) : 15518 - 15531

← 1 2 3 4 5 →