Thermodynamic study of the solubility of benzocaine in some organic and aqueous solvents

被引：45
|
作者：
Avila, CM [1 ]
Martínez, F [1 ]
机构：
[1] Univ Nacl Colombia, Dept Pharm, Bogota, DC, Colombia
来源：
JOURNAL OF SOLUTION CHEMISTRY | 2002年 / 31卷 / 12期
关键词：
benzocaine; solubility; solution thermodynamics; activity coefficients; partial miscibility;
D O I：
10.1023/A:1021825509697
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The thermodynamic functions free energy, enthalpy, and entropy of solution, were evaluated from solubility data of benzocaine determined at several temperatures in octanol, water, and the mutually saturated solvents, in isopropyl myristate, water, and the mutually saturated solvents, and in cyclohexane. In aqueous media the solubility was determined at pH 7.4 and ionic strength 0.15 mol-L-1. The excess free energy and the activity coefficients of the solutes also were determined. The solubility was higher in organic media, such as octanol and isopropyl myristate, than in aqueous media and cyclohexane.
引用
收藏
页码：975 / 985
页数：11
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