Effect of valsartan on renal handling of uric acid in healthy subjects

被引：0
|
作者：
González-Ortiz, M [1 ]
Mora-Martínez, JM [1 ]
Martínez-Abundis, E [1 ]
Balcázar-Muñoz, BR [1 ]
机构：
[1] W Natl Med Ctr, Mexican Inst Social Secur, Med Res Unit Clin Epidemiol, Guadalajara, Jalisco, Mexico
来源：
JOURNAL OF NEPHROLOGY | 2000年 / 13卷 / 02期
关键词：
valsartan; AT1 receptor antagonist; uric acid excretion; renal handling of uric acid;
D O I：
暂无
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Objective: To evaluate the effect of valsartan on renal handling of uric acid in healthy subjects. Methods: A randomized, single-blind, placebo-controlled clinical trial was performed in twelve healthy volunteers. Six received a morning dose of valsartan 80 mg orally during 14 to 21 days and the other six received placebo. Before and after valsartan or placebo, clearance, fractional excretion and excretion uric acid rates were calculated. Presecretory reabsorption, tubular secretion and postsecretory reabsorption of uric acid were assessed by pharmacological tests using pyrazinamide or probenecid, Results: There were no differences in clearance, fractional excretion and excretion uric acid rates with valsartan and placebo. Valsartan did not affect presecretory reabsorption (p = 0,92), tubular secretion (p = 0.62) or postsecretory reabsorption (p = 0.52) of uric acid. Conclusion: Valsartan did not significantly affect renal handling of uric acid in healthy subjects.
引用
收藏
页码：126 / 128
页数：3
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