Insulin inhibits secretin-stimulated ductal secretion in bile duct ligated (BDL) rats through activation of Ca2+-dependent protein kinase C (PKC) which leads to downregulation of protein kinase A (PKA).

被引：0
|
作者：
Lesage, G
Glaser, S
Marzioni, M
Marucci, L
Benedetti, A
Alvaro, D
Alpini, G
机构：
[1] Scott & White Mem Hosp & Clin, Temple, TX 76508 USA
[2] Texas A&M Univ, Temple, TX USA
[3] Univ Ancona, Ancona, Italy
[4] Univ Rome, Rome, Italy
[5] VA Hosp, Temple, TX USA
来源：
HEPATOLOGY | 2001年 / 34卷 / 04期
关键词：
D O I：
暂无
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
1228
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收藏
页码：479A / 479A
页数：1
相关论文
共 18 条
  • [1] Insulin inhibits secretin-induced ductal secretion in bile duct ligated (BDL) rats through a mechanism involving Ca2+-dependent protein kinase C (PKC) alpha isoform activation.
    LeSage, G
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    [J]. HEPATOLOGY, 2000, 32 (04) : 432A - 432A
  • [2] Insulin inhibits secretin-stimulated ductal bile secretion in bile duct-ligated (BDL) rats by interaction with insulin receptors on cholangiocytes
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    Lasater, J
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    [J]. GASTROENTEROLOGY, 1998, 114 (04) : A1287 - A1287
  • [3] D2 (but not D1 and D3) dopaminergic receptor agonists inhibit secretin-stimulated ductal secretion of bile duct ligated (BDL) rats through selective activation of the CA2+ dependent PKC gamma and downregulation of PKA activity.
    Glaser, S
    Alvaro, D
    Marzioni, M
    Stoica, G
    Ueno, Y
    Francis, H
    Phinizy, JL
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    Barbaro, B
    Mancino, MG
    LeSage, G
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    [J]. HEPATOLOGY, 2002, 36 (04) : 344A - 344A
  • [4] The α-2 adrenergic receptor agonist, UK14,304, inhibits secretin-stimulated ductal secretion of bile duct ligated (BDL) rats by activation of the G-protein GαI.
    Francis, H
    Glaser, S
    Alvaro, D
    Taffetani, S
    Marucci, L
    Benedetti, A
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    Marzioni, M
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    Baumann, B
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    Alpini, G
    [J]. HEPATOLOGY, 2003, 38 (04) : 678A - 679A
  • [5] Castration reduces cholangiocyte hyperplasia and secretin-stimulated ductal secretion of bile duct ligated (BDL) rats by downregulation of the cAMP-dependent ERK1/2 pathway
    Venter, Julie
    Glaser, Shannon
    Wise, Candace
    Francis, Heather
    Vaculin, Bradley T.
    Kopriva, Shelley
    Savage, Jennifer
    Alpini, Gianfranco
    [J]. GASTROENTEROLOGY, 2008, 134 (04) : A777 - A777
  • [6] Gastrin reverses established cholangiocyte proliferation and enhanced secretin-stimulated ductal secretion of BDL rats by activation of apoptosis through increased expression of Ca2+-dependent PKC isoforms
    Glaser, S
    Alvaro, D
    Ueno, Y
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    [J]. LIVER INTERNATIONAL, 2003, 23 (02) : 78 - 88
  • [7] ALPHA-1 (but not beta-1) adrenergic agonists potentiate secretin-stimulated ductal secretion in bile duct ligated (BDL) rats through cross-talk between Ca2+-dependent PKC and adenylyl cyclase pathways.
    Lesage, G
    Glaser, S
    Alvaro, D
    Marzioni, M
    Ueno, Y
    Francis, H
    Alpini, G
    [J]. HEPATOLOGY, 2001, 34 (04) : 477A - 477A
  • [8] The alpha-2 adrenergic receptor agonist, UK14,304, inhibits secretin-stimulated ductal secretion of bile duct ligated (BDL) rats by a decrease in camp levels and PKA activity.
    Alvaro, D
    Francis, H
    Glaser, S
    Marucci, L
    Benedetti, A
    Ueno, Y
    Marzioni, M
    Phinizy, JL
    Rashid, S
    Alpini, G
    [J]. HEPATOLOGY, 2002, 36 (04) : 462A - 462A
  • [9] The α2-adrenergic receptor agonist UK 14,304 inhibits secretin-stimulated ductal secretion by downregulation of the cAMP system in bile duct-ligated rats
    Francis, Heather
    LeSage, Gene
    DeMorrow, Sharon
    Alvaro, Domenico
    Ueno, Yoshiyuki
    Venter, Julie
    Glaser, Shannon
    Mancino, Maria Grazia
    Marucci, Luca
    Benedetti, Antonio
    Alpini, Gianfranco
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2007, 293 (04): : C1252 - C1262
  • [10] Neutralization of vascular endothelial growth Factor C (VEGF-C) by chronic administration of ANTI-VEGF-C antibody inhibits cholangiocyte proliferation and secretin-stimulated ductal secretion of bile duct ligated (BDL) rats.
    Barbaro, B
    Glaser, S
    Gaudio, E
    Francis, H
    Marzioni, M
    Venter, J
    Stoica, G
    Ueno, Y
    Baumann, B
    Franchitto, A
    Onori, P
    Phinizy, JL
    LeSage, G
    Alpini, G
    [J]. HEPATOLOGY, 2002, 36 (04) : 224A - 224A
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