Comparative Efficacy of Chinese Herbal Injections for Treating Severe Pneumonia: A Systematic Review and Bayesian Network Meta-Analysis of Randomized Controlled Trials

被引:3
|
作者
Niu, Liqing [1 ,2 ]
Xiao, Lu [1 ,2 ,3 ]
Zhang, Xuemin [1 ,2 ]
Liu, Xuezheng [1 ,2 ]
Liu, Xinqiao [1 ,2 ]
Huang, Xianglong [1 ,2 ,3 ]
Zhang, Mingzhu [1 ,2 ]
机构
[1] Tianjin Univ Tradit Chinese Med, Teaching Hosp 1, Dept Emergency, Tianjin, Peoples R China
[2] Natl Clin Res Ctr Chinese Med Acupuncture & Moxib, Tianjin, Peoples R China
[3] Tianjin Univ Tradit Chinese Med, State Key Lab Multifract Tradit Chinese Med, Tianjin, Peoples R China
关键词
network meta-analysis; severe pneumonia; Chinese herbal injections; combination therapy; antibiotic; COMMUNITY-ACQUIRED PNEUMONIA; INFECTIOUS-DISEASES-SOCIETY; XUEBIJING INJECTION; THORACIC-SOCIETY; CORTICOSTEROIDS; COVID-19;
D O I
10.3389/fphar.2021.743486
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Background: Severe pneumonia (SP) has a high mortality rate and is responsible for significant healthcare costs. Chinese herbal injections (CHIs) have been widely used in China as a novel and promising treatment option for SP. Therefore, this study assessed and ranked the effectiveness of CHIs to provide more sights for the selection of SP treatment. Method: Seven databases were searched from their inception up to April 1, 2021. The methodological quality of included study was evaluated by the Cochrane risk-of-bias tool. Then, a Bayesian network meta-analysis (NMA) was performed by OpenBUGS 3.2.3 and STATA 14.0 software. The surface under the cumulative ranking curve (SUCRA) probability values were applied to rank the examined treatments. A clustering analysis was utilized to compare the effect of CHIs between two different outcomes. Results: A total of 64 eligible randomized controlled trials (RCTs) involving 5,904 participants were identified for this analysis. Six CHIs including Xuebijing injection (XBJ), Tanreqing injection (TRQ), Reduning injection (RDN), Xiyanping injection (XYP), Shenfu injection (SF), and Shenmai injection (SM) were included. The results of the NMA showed that XBJ [odds ratio (OR) = 0.24, 95% credible interval (CI): 0.19, 0.30], TRQ (OR = 0.22, 95% CI: 0.12, 0.37), RDN (OR = 0.29, 95% CI: 0.04, 0.94), and SM (OR = 0.27, 95% CI: 0.08, 0.63) combined with conventional Western medicine (WM) improved the clinical effective rate more significantly than WM alone. Based on SUCRA values, TRQ + WM (SUCRA: 66.4%) ranked the highest in improving the clinical effective rate, second in four different outcomes, and third in only one. According to the cluster analysis, TRQ + WM exerted a positive effect on improving the efficacy of SP. As for safety, less than 30% (18 RCTs) of the included studies reported adverse drug reactions/adverse drug events (ADRs/ADEs), including 14 RCTs of XBJ, 3 RCTs of TRQ, and 1 RCT of RDN. Conclusion: In conclusion, the study found that the CHIs as co-adjuvant therapy could be beneficial for patients with SP. TRQ + WM showed an outstanding improvement in patients with SP considering both the clinical effective rate and other outcomes. Systematic Review Registration:[https://www.crd.york.ac.uk/prospero/], identifier[CRD42021244587].
引用
收藏
页数:18
相关论文
共 50 条
  • [1] Comparative efficacy of Chinese herbal injections for treating severe pneumonia: A protocol for systematic review and Bayesian network meta-analysis of randomized controlled trials
    Xiao, Lu
    Niu, Liqing
    Zhang, Xuemin
    Liu, Xuezheng
    Liu, Xinqiao D.
    Sun, Chongxiang D.
    Yang, Xiaokun D.
    Florez, Ivan D.
    [J]. PLOS ONE, 2022, 17 (05):
  • [2] Comparative Efficacy of Chinese Herbal Injections for Treating Pediatric Bronchopneumonia: A Bayesian Network Meta-Analysis of Randomized Controlled Trials
    Duan, Xiaojiao
    Wang, Haojia
    Wu, Jiarui
    Guo, Yubo
    Wan, Kaihuan
    Liu, Xinkui
    Zeng Xiantao
    Zhang, Xiaomeng
    [J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2020, 2020
  • [3] Comparative Efficacy of Tonic Chinese Herbal Injections for Treating Sepsis or Septic Shock: A Systematic Review and Bayesian Network Meta-Analysis of Randomized Controlled Trials
    Xiao, Lu
    Niu, Liqing
    Xu, Xinyi
    Zhao, Yuetong
    Yue, Linkai
    Liu, Xinqiao
    Li, Guiwei
    [J]. FRONTIERS IN PHARMACOLOGY, 2022, 13
  • [4] Comparative efficacy of Chinese herbal injections for angina pectoris: A Bayesian network meta-analysis of randomized controlled trials
    Wang Kaihuan
    Wu Jiarui
    Duan Xiaojiao
    Zhang Dan
    Lin Xi
    Zhang Sixuan
    Ni Mengwei
    Liu Shuyu
    Meng Ziqi
    Gao Xiaoyan
    Tan Peng
    Liu Yonggang
    [J]. COMPLEMENTARY THERAPIES IN MEDICINE, 2019, 43 : 208 - 217
  • [5] Comparative Efficacy of Chinese Herbal Injections for the Treatment of Herpangina: A Bayesian Network Meta-Analysis of Randomized Controlled Trials
    Duan, Xiaojiao
    Wang, Haojia
    Wu, Jiarui
    Zhou, Wei
    Wang, Kaihuan
    Liu, Xinkui
    [J]. FRONTIERS IN PHARMACOLOGY, 2020, 11
  • [6] Comparative Efficacy of Chinese Herbal Injections for Septic Shock: A Bayesian Network Meta-Analysis of Randomized Controlled Trials
    Huang, Peiying
    Chen, Yan
    Zhang, Haobo
    Chen, Bojun
    Zhao, Shuai
    Feng, Yuchao
    Lei, Sisi
    Wu, Qihua
    [J]. FRONTIERS IN PHARMACOLOGY, 2022, 13
  • [7] Comparative efficacy of Chinese herbal injections in patients with cardiogenic shock (CS): a systematic review and Bayesian network meta-analysis of randomized controlled trials
    Yue, Linkai
    Xiao, Lu
    Zhang, Xuemin
    Niu, Liqing
    Wen, Yue
    Li, Xiaowei
    Wang, Ying
    Xing, Guanghe
    Li, Guiwei
    [J]. FRONTIERS IN PHARMACOLOGY, 2024, 15
  • [8] Comparative efficacy of Chinese herbal injections combined with azithromycin for mycoplasma pneumonia in children: A Bayesian network meta-analysis of randomized controlled trials
    Duan, Xiaojiao
    Wang, Kaihuan
    Wu, Jiarui
    Zhang, Dan
    Liu, Xinkui
    Ni, Mengwei
    Liu, Shuyu
    Meng, Ziqi
    [J]. JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS, 2019, 44 (05) : 675 - 684
  • [9] Comparative efficacy of Chinese herbal injections for the treatment of community-acquired pneumonia: A Bayesian network meta-analysis of randomized controlled trials
    Huang, Xingyue
    Duan, Xiaojiao
    Zhu, Yingli
    Wang, Kaihuan
    Wu, Jiarui
    Tian, Xuehao
    [J]. PHYTOMEDICINE, 2019, 63
  • [10] Comparative efficacy of Chinese herbal injections for treating acute cerebral infarction: a network meta-analysis of randomized controlled trials
    Shi Liu
    Jia-Rui Wu
    Dan Zhang
    Kai-Huan Wang
    Bing Zhang
    Xiao-Meng Zhang
    Di Tan
    Xiao-Jiao Duan
    Ying-Ying Cui
    Xin-Kui Liu
    [J]. BMC Complementary and Alternative Medicine, 18