Prognostic factors for cerebral palsy and motor impairment in children born very preterm or very low birthweight: a systematic review

被引:88
|
作者
Linsell, Louise [1 ]
Malouf, Reem [1 ]
Morris, Joan [2 ]
Kurinczuk, Jennifer J. [1 ]
Marlow, Neil [3 ]
机构
[1] Univ Oxford, Nuffield Dept Populat Hlth, NPEU, Old Rd Campus, Oxford OX3 7LF, England
[2] Queen Mary Univ London, Barts & London Sch Med & Dent, Ctr Environm & Prevent Med, London, England
[3] UCL, Inst Womens Hlth, London, England
来源
关键词
DEVELOPMENTAL COORDINATION DISORDER; LOW-GESTATIONAL-AGE; NEURODEVELOPMENTAL OUTCOMES; INFANTS BORN; INTRAVENTRICULAR HEMORRHAGE; ANTENATAL CORTICOSTEROIDS; MAGNESIUM-SULFATE; NATIONAL COHORT; REGIONAL COHORT; RISK-FACTORS;
D O I
10.1111/dmcn.12972
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
AIM There is a large literature reporting risk factor analyses for poor neurodevelopment in children born very preterm (VPT: <= 32wks) or very low birthweight (VLBW: <= 1250g), which to date has not been formally summarized. The aim of this paper was to identify prognostic factors for cerebral palsy (CP) and motor impairment in children born VPT/VLBW. METHOD A systematic review was conducted using Medline, Embase, and Pyscinfo databases to identify studies published between 1 January 1990 and 1 June 2014 reporting multivariable prediction models for poor neurodevelopment in VPT/VLBW children (registration number CRD42014006943). Twenty-eight studies for motor outcomes were identified. RESULTS There was strong evidence that intraventricular haemorrhage and periventricular leukomalacia, and some evidence that the use of postnatal steroids and non-use of antenatal steroids, were prognostic factors for CP. Male sex and gestational age were of limited use as prognostic factors for CP in cohorts restricted to <= 32 weeks gestation; however, in children older than 5 years with no major disability, there was evidence that male sex was a predictive factor for motor impairment. INTERPRETATION This review has identified factors which may be of prognostic value for CP and motor impairment in VPT/VLBW children and will help to form the basis of future prognostic research.
引用
收藏
页码:554 / 569
页数:16
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