Isolation and identification of antibacterial neo-compounds from the red ants of ChangBai Mountain, Tetramorium sp.

被引：19
|
作者：
Song, Zheng-Wei [1 ]
Liu, Pu [1 ]
Yin, Wei-Ping [1 ]
Jiang, Ya-Ling [1 ]
Ren, Yun-lai [1 ]
机构：
[1] Henan Univ Sci & Technol, Sch Chem Engn & Pharmaceut, Luoyang 471003, Henan, Peoples R China
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2012年 / 22卷 / 06期
关键词：
The red ants of ChangBai Mountain; Tetramorium sp; Antibacterial neo-compounds; Structural elucidation; Antibacterial activity; Insect chemistry; PURIFICATION; PEPTIDES; COUMARIN; INSECTS;
D O I：
10.1016/j.bmcl.2012.01.112
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Three novel coumarin compounds along with two known amide alkaloids were isolated from a methanol extract of the red ants of ChangBai Mountain, Tetramorium sp. Their structures were identified on the basis of IR, 2D NMR (H-1-H-1 COSY, HSQC, HMBC and NOESY) and HRESIMS analysis. Antibacterial activity of all the compounds was evaluated using KB paper diffusion through measurement of inhibiting zone. It was found that four of all the compounds exhibited significant inhibitory activity against Gram-positive bacteria Bacillus subtilis with MIC values of 25 mu g/ml (compounds 1-3) and 15 mu g/ml (compound 4). (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2175 / 2181
页数：7
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