Ulcerative colitis after autologous peripheral blood stem cell transplantation for non-Hodgkin's lymphoma

被引：9
|
作者：
Koike, K
Kohda, K
Kuga, T
Nakazawa, O
Ando, M
Takayanagi, N
Matsunaga, T
Sakamaki, S
Niitsu, Y
机构：
[1] Japanese Red Cross Asahikawa Hosp, Dept Hematol, Asahikawa, Hokkaido 0700061, Japan
[2] Japanese Red Cross Asahikawa Hosp, Dept Pathol, Asahikawa, Hokkaido 0700061, Japan
[3] Sapporo Med Univ, Sch Med, Dept Internal Med 4, Sapporo, Hokkaido, Japan
来源：
BONE MARROW TRANSPLANTATION | 2001年 / 28卷 / 06期
关键词：
ulcerative colitis; autologous stem cell transplantation; tropomyosin;
D O I：
10.1038/sj.bmt.1703205
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
A 54-year-old woman with peripheral T cell lymphoma in second complete remission (CR) received an autologous peripheral blood stem cell transplant (PBSCT). Antibiotic-resistant bloody diarrhea, and fever developed 110 days after transplant. Blood and stool cultures were negative. Skin rash was not observed. Barium enema and colonoscopy showed typical features of pancolonic-type ulcerative colitis (UC). Endoscopic biopsies confirmed the diagnosis of UC. Mesalazine and immunosuppressive therapy improved symptoms dramatically. We detected serum antibodies against synthetic tropomyosin (TM) peptide when UC was diagnosed. We postulate that autoimmunity including autoreactive anti-TM antibodies may be involved in the pathogenesis of UC after autologous PBSCT in this patient.
引用
收藏
页码：619 / 621
页数：3
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