Osteoporosis and the growth hormone-insulin-like growth factor axis

被引：32
|
作者：
Geusens, PPMM
Boonen, S
机构：
[1] State Univ Limburg Hosp, Dept Rheumatol, NL-6202 AZ Maastricht, Netherlands
[2] Limburgs Univ Ctr, Inst Biomed Res, B-3610 Diepenbeek, Belgium
[3] Katholieke Univ Leuven, Leuven Univ Ctr Metab Bone Dis, B-3001 Louvain, Belgium
来源：
HORMONE RESEARCH | 2002年 / 58卷
关键词：
osteoporosis; insulin-like growth factor; growth hormone; hip fracture;
D O I：
10.1159/000066483
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Osteoporosis is the result of an imbalance between bone resorption and bone formation. Currently, mainly drugs that inhibit bone resorption are available for the treatment of osteoporosis. A new approach in the treatment of osteoporosis is the use of anabolic agents that increase bone turnover, both bone formation and resorption. Growth hormone (GH) and insulin-like growth factors (IGFs) are essential in the development and growth of the skeleton and for the maintenance of bone mass and density. We will review the evidence of GH and IGF-1 in the pathophysiology and treatment of osteoporosis. Copyright (C) 2002 S. Karger AG, Basel.
引用
收藏
页码：49 / 55
页数：7
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