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Psychoactive Drugs Induce the SOS Response and Shiga Toxin Production in Escherichia coli
被引:5
|作者:
Crane, John K.
[1
]
Salehi, Mashal
[1
]
Alvarado, Cassandra L.
[1
]
机构:
[1] Univ Buffalo, Dept Med, Div Infect Dis, Buffalo, NY 14221 USA
来源:
关键词:
serotonin selective reuptake inhibitors;
phenothiazines;
RecA;
hypermutation;
enterohemorrhagic E;
coli;
Shiga-toxigenic E;
hemolytic-uremic syndrome;
ANTIBIOTICS;
PROTEIN;
TRENDS;
D O I:
10.3390/toxins13070437
中图分类号:
TS2 [食品工业];
学科分类号:
0832 ;
摘要:
Several classes of non-antibiotic drugs, including psychoactive drugs, proton-pump inhibitors (PPIs), non-steroidal anti-inflammatory drugs (NSAIDs), and others, appear to have strong antimicrobial properties. We considered whether psychoactive drugs induce the SOS response in E. coli bacteria and, consequently, induce Shiga toxins in Shiga-toxigenic E. coli (STEC). We measured the induction of an SOS response using a recA-lacZ E. coli reporter strain, as RecA is an early, reliable, and quantifiable marker for activation of the SOS stress response pathway. We also measured the production and release of Shiga toxin 2 (Stx2) from a classic E. coli O157:H7 strain, derived from a food-borne outbreak due to spinach. Some, but not all, serotonin selective reuptake inhibitors (SSRIs) and antipsychotic drugs induced an SOS response. The use of SSRIs is widespread and increasing; thus, the use of these antidepressants could account for some cases of hemolytic-uremic syndrome due to STEC and is not attributable to antibiotic administration. SSRIs could have detrimental effects on the normal intestinal microbiome in humans. In addition, as SSRIs are resistant to environmental breakdown, they could have effects on microbial communities, including aquatic ecosystems, long after they have left the human body.
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页数:10
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