Psychoactive Drugs Induce the SOS Response and Shiga Toxin Production in Escherichia coli

被引:5
|
作者
Crane, John K. [1 ]
Salehi, Mashal [1 ]
Alvarado, Cassandra L. [1 ]
机构
[1] Univ Buffalo, Dept Med, Div Infect Dis, Buffalo, NY 14221 USA
关键词
serotonin selective reuptake inhibitors; phenothiazines; RecA; hypermutation; enterohemorrhagic E; coli; Shiga-toxigenic E; hemolytic-uremic syndrome; ANTIBIOTICS; PROTEIN; TRENDS;
D O I
10.3390/toxins13070437
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
Several classes of non-antibiotic drugs, including psychoactive drugs, proton-pump inhibitors (PPIs), non-steroidal anti-inflammatory drugs (NSAIDs), and others, appear to have strong antimicrobial properties. We considered whether psychoactive drugs induce the SOS response in E. coli bacteria and, consequently, induce Shiga toxins in Shiga-toxigenic E. coli (STEC). We measured the induction of an SOS response using a recA-lacZ E. coli reporter strain, as RecA is an early, reliable, and quantifiable marker for activation of the SOS stress response pathway. We also measured the production and release of Shiga toxin 2 (Stx2) from a classic E. coli O157:H7 strain, derived from a food-borne outbreak due to spinach. Some, but not all, serotonin selective reuptake inhibitors (SSRIs) and antipsychotic drugs induced an SOS response. The use of SSRIs is widespread and increasing; thus, the use of these antidepressants could account for some cases of hemolytic-uremic syndrome due to STEC and is not attributable to antibiotic administration. SSRIs could have detrimental effects on the normal intestinal microbiome in humans. In addition, as SSRIs are resistant to environmental breakdown, they could have effects on microbial communities, including aquatic ecosystems, long after they have left the human body.
引用
收藏
页数:10
相关论文
共 50 条
  • [1] Human neutrophils and their products induce shiga toxin production by enterohemorrhagic Escherichia coli
    Wagner, PL
    Acheson, DWK
    Waldor, MK
    INFECTION AND IMMUNITY, 2001, 69 (03) : 1934 - 1937
  • [2] Transcriptional and Translational Inhibitors Block SOS Response and Shiga Toxin Expression in Enterohemorrhagic Escherichia coli
    Michael Berger
    Iqbal Aijaz
    Petya Berger
    Ulrich Dobrindt
    Gerald Koudelka
    Scientific Reports, 9
  • [3] Toxin gene expression by shiga toxin-producing Escherichia coli:: the role of antibiotics and the bacterial SOS response
    Kimmitt, PT
    Harwood, CR
    Barer, MR
    EMERGING INFECTIOUS DISEASES, 2000, 6 (05) : 458 - 465
  • [4] Transcriptional and Translational Inhibitors Block SOS Response and Shiga Toxin Expression in Enterohemorrhagic Escherichia coli
    Berger, Michael
    Aijaz, Iqbal
    Berger, Petya
    Dobrindt, Ulrich
    Koudelka, Gerald
    SCIENTIFIC REPORTS, 2019, 9 (1)
  • [5] Escherichia coli Shiga toxin
    Nakao, H
    Takeda, T
    JOURNAL OF NATURAL TOXINS, 2000, 9 (03) : 299 - 313
  • [6] Effects of azithromycin on Shiga toxin production by Escherichia coli and subsequent host inflammatory response
    Ohara, T
    Kojio, S
    Taneike, I
    Nakagawa, S
    Gondaira, F
    Tamura, Y
    Gejyo, F
    Zhang, HM
    Yamamoto, T
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2002, 46 (11) : 3478 - 3483
  • [7] Rifaximin does not induce toxin production or phage-mediated lysis of Shiga toxin-producing Escherichia coli
    Ochoa, Theresa J.
    Chen, Jane
    Walker, Christopher M.
    Gonzales, Elsa
    Cleary, Thomas G.
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2007, 51 (08) : 2837 - 2841
  • [8] Testing of urinary Escherichia coli isolates for Shiga toxin production
    Thorpe, CM
    Acheson, DWK
    CLINICAL INFECTIOUS DISEASES, 2001, 32 (10) : 1517 - 1518
  • [9] Oxidative Stress in Shiga Toxin Production by Enterohemorrhagic Escherichia coli
    Licznerska, Katarzyna
    Nejman-Falenczyk, Bozena
    Bloch, Sylwia
    Dydecka, Aleksandra
    Topka, Gracja
    Gasior, Tomasz
    Wegrzyn, Alicja
    Wegrzyn, Grzegorz
    OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2016, 2016
  • [10] Nonpathogenic Escherichia coli can contribute to the production of Shiga toxin
    Gamage, SD
    Strasser, JE
    Chalk, CL
    Weiss, AA
    INFECTION AND IMMUNITY, 2003, 71 (06) : 3107 - 3115