Label-free plasmonic assisted optical trapping of single DNA molecules

DNA molecules are hard to catch using traditional optical trapping due to the nanometer width of their chains. Here we experimentally demonstrate a label-free optical trapping of a single micrometer lambda-DNA in solution by the aid of plasmonic gold nanoparticles (GNPs), where a double-laser trap induces strong optical interparticle forces for the tweezer. We examine such sub-resolved interparticle forces by tracking the GNP dynamics in solution. Moreover, surface-enhanced Raman scattering signals of trapped lambda-DNA have also been measured simultaneously in the same setup. In comparison with prior works, ours benefit from the excitation in a dynamic configuration without fabrication. This technique opens a new avenue for all-optical manipulation of biomolecules, as well as ultra-sensitive bio-medical sensing applications. (C) 2021 Optical Society of America