Cannabidiol for Rapid Eye Movement Sleep Behavior Disorder

被引：40
|
作者：
de Almeida, Carlos M. O. [1 ]
Brito, Manuelina M. C. [2 ]
Bosaipo, Nayanne B. [2 ]
Pimentel, Angela V. [2 ]
Tumas, Vitor [2 ]
Zuardi, Antonio W. [2 ,3 ]
Crippa, Jose A. S. [2 ,3 ]
Hallak, Jaime E. C. [2 ,3 ]
Eckeli, Alan L. [2 ]
机构：
[1] State Univ Amazonas, Sch Hlth Sci, Manaus, Amazonas, Brazil
[2] Univ Sao Paulo, Fac Med Ribeirao Preto, Div Neurol, Dept Neurosci & Sci Behav, Sao Paulo, Brazil
[3] CNPq FAPESP CAPES, Natl Inst Sci & Technol Translat Med, Sao Paulo, Brazil
来源：
MOVEMENT DISORDERS | 2021年 / 36卷 / 07期
基金：
巴西圣保罗研究基金会;
关键词：
sleep; cannabidiol; rapid eye movement sleep behavioral disorder; Parkinson' s disease; PARKINSONS-DISEASE; REM-SLEEP; DEPRESSION; VALIDATION; VERSION; SCALE;
D O I：
10.1002/mds.28577
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Background REM sleep behaviour disorder (RBD) is a common non-motor feature of Parkinson's disease (PD). Cannabidiol (CBD) is one of the main non-psychoactive components of Cannabis sativa and may represent an alternative route for treating RBD. Objective This study assessed the efficacy and safety of CBD for RBD in PD. Methods We conducted a phase II/III, double-blind, placebo-controlled clinical trial in 33 patients with RBD and PD. Patients were randomized 1:1 to CBD in doses of 75 to 300mg or matched capsules placebo and were followed up for 14 weeks. The primary outcomes were the frequency of nights with RBD, CGI-I, and CGI-S. Results CBD showed no difference to placebo for primary outcomes. Regarding secondary outcomes, we observed a significant improvement in average sleep satisfaction from the 4th to 8th week in the CBD versus placebo group with P = 0.049 and P = 0.038, respectively. Conclusion CBD, as an adjunct therapy, showed no reduction in RBD manifestations in PD patients. A transient improvement in sleep satisfaction with a dose of 300mg has been noted. (c) 2021 International Parkinson and Movement Disorder Society
引用
收藏
页码：1711 / 1715
页数：5
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