Yarrowia lipolytica: recent achievements in heterologous protein expression and pathway engineering

被引：160
|
作者：
Madzak, Catherine [1 ]
机构：
[1] INRA, Micalis Inst, UMR1319, F-78850 Thiverval Grignon, France
来源：
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY | 2015年 / 99卷 / 11期
关键词：
Yarrowia lipolytica; Oleaginous yeast; Heterologous protein; Expression; Secretion; Surface display; Genetic engineering; Biotechnology; Lipid metabolism; CITRIC-ACID PRODUCTION; ALPHA-KETOGLUTARATE PRODUCTION; ARAUCARIAE EPOXIDE HYDROLASE; FUNGUS TRAMETES-VERSICOLOR; LIPID-ACCUMULATION; GENE-EXPRESSION; SURFACE DISPLAY; ALKALINE PROTEASE; BETA-OXIDATION; ENCODING GENE;
D O I：
10.1007/s00253-015-6624-z
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The oleaginous yeast Yarrowia lipolytica has become a recognized system for expression/secretion of heterologous proteins. This non-conventional yeast is currently being developed as a workhorse for biotechnology by several research groups throughout the world, especially for single-cell oil production, whole cell bioconversion and upgrading of industrial wastes. This mini-review presents established tools for protein expression in Y. lipolytica and highlights novel developments in the areas of promoter design, surface display, and host strain or metabolic pathway engineering. An overview of the industrial and commercial biotechnological applications of Y. lipolytica is also presented.
引用
收藏
页码：4559 / 4577
页数：19
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