A potent inflammatory response is triggered in asymptomatic blood donors with recent SARS-CoV-2 infection

被引：0
|
作者：
Martins, Marina Lobato [1 ]
Fernandes Da Silva-Malta, Maria Clara [1 ]
Araujo, Argus Leao [2 ]
Goncalves, Fabiola Araujo [2 ]
Botelho, Maiara de Lourdes [2 ]
de Oliveira, Isabelle Rocha [3 ]
Madeira Ferreira Boy, Luciana de Souza [1 ]
Moreira, Helinse Medeiros [1 ]
Barbosa-Stancioli, Edel Figueiredo [3 ]
Ribeiro, Maisa Aparecida [1 ]
Chaves, Daniel Goncalves [1 ]
机构：
[1] Fundacao Ctr Hematol & Hemoterapia Minas Gerais H, Belo Horizonte, MG, Brazil
[2] Fundacao Hosp Estado Minas Gerais, Hosp Eduardo Menezes, Belo Horizonte, MG, Brazil
[3] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Microbiol, Lab Virol Basica & Aplicada, Belo Horizonte, MG, Brazil
来源：
REVISTA DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL | 2022年 / 55卷
关键词：
SARS-CoV-2; COVID-19; Cytokines; Chemokines; Asymptomatic;
D O I：
10.1590/0037-8682-0239-2022
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Background: The inflammatory response plays a significant role in the outcome of coronavirus disease (COVID-19).Methods: We investigated plasma cytokine and chemokine concentrations in non-infected (NI), asymptomatic severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2)-infected blood donors (AS), and patients with severe COVID-19 (SC).Results: The SC group showed significantly higher levels of interleukin 6 (IL-6), IL-10, and CCL5 than the AS and NI groups. The SC and AS groups had considerably greater CXCL9 and CXCL10 concentrations than the NI group. Only NI and infected people showed separate clusters in the principal component analysis. Conclusions: SC, as well as AS was characterized by an inflammatory profile.
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页数：5
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