Inhibitory effect of selenium and change of glutathione peroxidase activity on rat glioma

被引：5
|
作者：
Zhang, ZH
Kimura, M
Itokawa, Y
机构：
[1] Department of Social Medicine, Graduate School of Medicine, Kyoto University
来源：
BIOLOGICAL TRACE ELEMENT RESEARCH | 1996年 / 55卷 / 1-2期
关键词：
selenium; glioma; brain bearing tumor; contralateral normal brain; rat; glutathione-peroxidase;
D O I：
10.1007/BF02784166
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The inhibitory effect of selenium (Se) and change of glutathione peroxidase activity during the development of brain tumors was investigated in Wistar rats. Four rat groups classified to match by age and weight were fed a diet containing 0, 0.5, 2.0, and 4.0 mu g Se/g. After 6 wk, the rats were injected with 3 x 10(6) Cg cells into the right frontal lobe parenchyma. Survival was significantly longer in the 0.5 and 2.0 mu g Se/g groups than in the Se-free and 4.0 mu g Se/g groups. The activity of glutathione peroxidase after development of tumors was significantly higher in the high Se group at 18 and 30 d.
引用
收藏
页码：31 / 38
页数：8
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