Lipid Mediators Are Critical in Resolving Inflammation: A Review of the Emerging Roles of Eicosanoids in Diabetes Mellitus

被引：49
|
作者：
Tessaro, Fernando H. G. [1 ]
Ayala, Thais S. [1 ]
Martins, Joilson O. [1 ]
机构：
[1] Univ Sao Paulo, Fac Pharmaceut Sci, Lab Immunoendocrinol, Dept Clin & Toxicol Anal, BR-05508000 Sao Paulo, SP, Brazil
来源：
BIOMED RESEARCH INTERNATIONAL | 2015年 / 2015卷
基金：
巴西圣保罗研究基金会;
关键词：
NECROSIS-FACTOR-ALPHA; PROSTAGLANDIN E-2; ARACHIDONIC-ACID; CELL-DIFFERENTIATION; INSULIN-RESISTANCE; BERAPROST SODIUM; MOUSE MODEL; MAST-CELLS; TNF-ALPHA; EXPRESSION;
D O I：
10.1155/2015/568408
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The biosynthesis pathway of eicosanoids derived from arachidonic acid, such as prostaglandins and leukotrienes, relates to the pathophysiology of diabetes mellitus (DM). A better understanding of how lipid mediators modulate the inflammatory process may help recognize key factors underlying the progression of diabetes complications. Our review presents recent knowledge about eicosanoid synthesis and signaling in DM-related complications, and discusses eicosanoid-related target therapeutics.
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页数：8
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