The settlement of the place in ancient times and the peoples who inhabited it are as follows: it is said that the earliest inhabitants of any part of the country were the Cyclopes and Laestrygonians. I cannot say what kind of people these were or where they came from or where they went in the end. On these points we must be content with what the poets have said and what anyone else may happen to know. The next settlers after them seem to have been the Sicanian, though according to the Sicanians themselves they were there first, and were the original inhabitants of the country.. After the fall of Troy, some of the Trojans escaped from the Achaens and came in ships to Sicily, where they settled next to the Sicanians and were called by the name of Elymi... The Sicels crossed over into Sicily from Italy, where they lived previously and from which they were driven by the Opicans... The first of the Hellenes to arrive were Chalcidians from Euboea with Thucles their founder.'' (Thucydides, The Peloponnesian War, Book VI). [Malone, Caroline; Stoddart, Simon] Univ Cambridge, Dept Archaeol, Cambridge CB2 3DZ, England University of Cambridge Malone, C (corresponding author), Univ Cambridge, Dept Archaeol, Cambridge CB2 3DZ, England. catm20@cus.cam.ac.uk [Anonymous], LANGUAGE GENES BIOL; [Anonymous], ARCHAEOLOGY GREEK CO; Balistreri A., 1994, PRIMA SICILIA ORIGIN; BREA LB, 1958, SICILY GREEKS; Cavalli-Sforza L. L., 1994, HIST GEOGRAPHY HUMAN; CULTRARO M., 1997, PRIMA SICILIA ORIGIN, P353; Finley M. I., 1979, ANCIENT SICILY; Holloway R., 1985, BRIT ARCHAEOLOGICAL, P389; la Rosa V., 1994, PREISTORIA BASSO BEL, P289; Leighton R., 1999, Sicily Before History: An Archaeological Survey from the Palaeolithic to the Iron Age; Malone C., ATT PRIM C IN PRESS; Morris Ian., 1987, Burial and Ancient Society: The Rise of the Greek City-State; Piperno M., 1997, PRIMA SICILIA ORIGIN, P83; Pluciennik M., 1996, ATT PRIM C IN PRESS; Tusa S., 1997, PRIMA SICILIA ORIGIN, P173 15 1 1 0 3 ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER ISSY-LES-MOULINEAUX 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE 1296-2074 1778-3674 J CULT HERIT J. Cult. Herit. OCT 2000 1 2 29 31 PII 1296-2074(00)01068-2/SCO 3 Archaeology; Art; Chemistry, Analytical; Geosciences, Multidisciplinary; Materials Science, Multidisciplinary; Spectroscopy Science Citation Index Expanded (SCI-EXPANDED); Arts & Humanities Citation Index (A&HCI) Archaeology; Art; Chemistry; Geology; Materials Science; Spectroscopy V20HZ 2024-02-28 WOS:000208132400004
J Manley, HJ Manley, HJ Role of angiotensin-converting-enzyme inhibition in patients with renal disease AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY English Article angiotensin-converting-enzyme inhibitors; clinical studies; kidney diseases; kidney failure DIABETIC NEPHROPATHY; PROTEINURIA; MICROALBUMINURIA; PROGRESSION; CAPTOPRIL; TRIAL Clinical studies evaluating the benefits of angiotensin-converting-enzyme (ACE) inhibitor therapy in patients likely,to develop renal disease are reviewed. Patients with diabetes or hypertension are at increased risk for development of renal disease. In patients with diabetic nephropathy, captopril therapy was associated with a 50% reduction in the, risk of death, dialysis, and transplantation and a significantly smaller increase in serum creatinine compared with placebo. Therapy with enalapril or lisinopril has been shown to limit the progression of renal disease in normoalbuminuric patients with diabetes. Long-term therapy with enalapril (up to seven years) has demonstrated the ability to preserve renal function in patients with diabetes and microalbuminuria. Over 4.5 years, patients with diabetes and at least one other cardiovascular risk factor had significant reductions in the risk Of overt nephropathy With ramipril therapy compared with placebo. In addition, ramipril is associated with preservation of renal function in patients with nondiabetic neuphropathy. Evidence suggesting a dissociation of the renal hemodynamic and antiproteinuric effects of ACE inhibition is presented. These positive effects of ACE inhibition cannot be explained by reductions in blood pressure alone. ACE inhibitors have renoprotective properties: beyond systemic blood: pressure reduction. Univ Missouri, Sch Med M3 C19, Kansas City, MO 64108 USA University of Missouri System; University of Missouri Kansas City Manley, HJ (corresponding author), Univ Missouri, Sch Med M3 C19, 2411 Holmes St, Kansas City, MO 64108 USA. Borchhardt K, 1997, KIDNEY INT, V52, P1622, DOI 10.1038/ki.1997.494; Breyer JA, 1996, KIDNEY INT, V50, P1651, DOI 10.1038/ki.1996.481; Chaturvedi N, 1997, LANCET, V349, P1787, DOI 10.1016/S0140-6736(96)10244-0; Foucan L, 1998, AM J MED, V104, P339, DOI 10.1016/S0002-9343(98)00056-4; GANSEVOORT RT, 1993, KIDNEY INT, V44, P579, DOI 10.1038/ki.1993.284; Gerstein HC, 2000, LANCET, V355, P253; Keane WF, 1999, AM J KIDNEY DIS, V33, P1004, DOI 10.1016/S0272-6386(99)70442-7; Kimmel PL, 1996, AM J KIDNEY DIS, V28, P202, DOI 10.1016/S0272-6386(96)90302-9; LEWIS EJ, 1993, NEW ENGL J MED, V329, P1456, DOI 10.1056/NEJM199311113292004; Luño J, 1998, KIDNEY INT, V54, pS112, DOI 10.1046/j.1523-1755.1998.06823.x; MAKI DD, 1995, ARCH INTERN MED, V155, P1073, DOI 10.1001/archinte.155.10.1073; MARRE M, 1988, BMJ-BRIT MED J, V297, P1092, DOI 10.1136/bmj.297.6656.1092; Maschio G, 1998, CURR OPIN NEPHROL HY, V7, P253, DOI 10.1097/00041552-199805000-00003; *NAT I DIAB DIG KI, 1999, US REN DAT SYST; Nosrati SM, 1997, AM J NEPHROL, V17, P511, DOI 10.1159/000169180; Ravid M, 1996, ARCH INTERN MED, V156, P286, DOI 10.1001/archinte.156.3.286; RAVID M, 1993, ANN INTERN MED, V118, P577, DOI 10.7326/0003-4819-118-8-199304150-00001; Ruggenenti P, 1997, LANCET, V349, P1857; Ruggenenti P, 1999, LANCET, V354, P359, DOI 10.1016/S0140-6736(98)10363-X; Ruggenenti P, 1998, LANCET, V352, P1252, DOI 10.1016/S0140-6736(98)04433-X; Ruggenenti P, 1997, Kidney Int Suppl, V63, pS54; Wolf G, 1997, AM J KIDNEY DIS, V29, P153, DOI 10.1016/S0272-6386(97)90023-8; Yusuf S, 2000, NEW ENGL J MED, V342, P154, DOI 10.1056/NEJM200001203420302 23 23 24 0 2 AMER SOC HEALTH-SYSTEM PHARMACISTS BETHESDA 7272 WISCONSIN AVE, BETHESDA, MD 20814 USA 1079-2082 1535-2900 AM J HEALTH-SYST PH Am. J. Health-Syst. Pharm. OCT 1 2000 57 19 1 S12 S18 10.1093/ajhp/57.suppl_1.S12 http://dx.doi.org/10.1093/ajhp/57.suppl_1.S12 7 Pharmacology & Pharmacy Science Citation Index Expanded (SCI-EXPANDED) Pharmacology & Pharmacy 361GD 11030018 hybrid 2024-02-28 WOS:000089714400004
J Manoj, N; Vijayan, M Manoj, N; Vijayan, M X-ray studies on crystalline complexes involving amino acids and peptides. XXXVI. Crystal structures of hydrated glycyl-L-histidine and L-histidyl-L-alanine complexes with oxalic acid JOURNAL OF PEPTIDE RESEARCH English Article chemical evolution and origin of life; dipeptide complex; peptide aggregation; pseudo symmetry; symmetric hydrogen bond; unusual ionization state DL-ARGININE; AGGREGATION; EVOLUTION; PATTERNS; STATE The crystal structures of the complexes of oxalic acid with glycyl-L-histidine and L-histidyl-L-alanine were determined. The three crystallographically independent peptide molecules in the complexes have closed conformations. The terminal carboxyl group of the dipeptide and the oxalate ion in the Gly-His complex exhibit unusual ionization states and are connected by a symmetric O- - -O hydrogen bond. The peptide aggregation in the complex is almost identical to that. in the corresponding semisuccinate complex and is similar to one of the predicted aggregation patterns for Ala-Ala, demonstrating that dipeptide aggregation is controlled primarily by main-chain interactions and is substantially unaffected by disturbing influences such as those arising from polar side chains ions and water molecules. The peptide molecules in the highly pseudosymmetric crystals of the His-Ata complex, however, exhibit a hitherto unobserved aggregation pattern. Thus, in spite of the repeated occurrence of a few patterns, the possibility of the existence of new patterns needs to be taken into account. Indian Inst Sci, Mol Biophys Unit, Bangalore 560012, Karnataka, India Indian Institute of Science (IISC) - Bangalore Vijayan, M (corresponding author), Indian Inst Sci, Mol Biophys Unit, Bangalore 560012, Karnataka, India. Manoj, Narayanan/W-2301-2019 Manoj, Narayanan/0000-0002-8144-1566 ALTOMERE A, 1997, AIR97 NEW PROGRAM SO; [Anonymous], 1970, J Mol Biol, V52, P1; Chandra NR, 1998, ACTA CRYSTALLOGR B, V54, P257, DOI 10.1107/S0108768197011543; GILLI P, 1994, J AM CHEM SOC, V116, P909, DOI 10.1021/ja00082a011; NORTH ACT, 1968, ACTA CRYSTALL A-CRYS, VA 24, P351, DOI 10.1107/S0567739468000707; PRASAD GS, 1993, ACTA CRYSTALLOGR B, V49, P348, DOI 10.1107/S0108768192008504; Ravishankar R, 1998, J BIOMOL STRUCT DYN, V15, P1093, DOI 10.1080/07391102.1998.10509003; SHELDRICK G, 1986, SHELXS86 PROGRAM CRY; Sheldrick G.M., 1997, SHELXTL-97; SURESH CG, 1985, INT J PEPT PROT RES, V26, P311; SURESH CG, 1985, INT J PEPT PROT RES, V26, P329; Suresh S, 1996, ACTA CRYSTALLOGR B, V52, P876, DOI 10.1107/S0108768196005368; SURESH S, 1995, J BIOSCIENCE, V20, P225, DOI 10.1007/BF02703270; SURESH S, 1994, INT J PEPT PROT RES, V43, P139; VIJAYAN M, 1988, PROG BIOPHYS MOL BIO, V52, P71, DOI 10.1016/0079-6107(88)90003-X; VIJAYAN M, 1980, FEBS LETT, V112, P135, DOI 10.1016/0014-5793(80)80164-5; VIJAYAN M, 1985, CURR SCI INDIA, V54, P771; ZSOLNAI L, 1994, ZORTEP INTERACTIVE G 18 6 7 0 4 MUNKSGAARD INT PUBL LTD COPENHAGEN 35 NORRE SOGADE, PO BOX 2148, DK-1016 COPENHAGEN, DENMARK 1397-002X J PEPT RES J. Pept. Res. OCT 2000 56 4 210 217 10.1034/j.1399-3011.2000.00741.x http://dx.doi.org/10.1034/j.1399-3011.2000.00741.x 8 Biochemical Research Methods; Biochemistry & Molecular Biology Science Citation Index Expanded (SCI-EXPANDED) Biochemistry & Molecular Biology 362BH 11083060 2024-02-28 WOS:000089758400004
J Marmottant, P; Villermaux, E; Clanet, C Marmottant, P; Villermaux, E; Clanet, C Transient surface tension of an expanding liquid sheet JOURNAL OF COLLOID AND INTERFACE SCIENCE English Article adsorption kinetics; dynamic surface tension; expanded film; stretched interface AIR WATER INTERFACE; ADSORPTION-KINETICS We address the problem of dynamic surface tension using measurements of sheet diameters that results from the impact of a liquid jet of diameter d(o) on a small disk of diameter d(i) (d(i)/d(o) similar or equal to 4), At low velocities, the sheet diameter D is related to d(o) by the Weber number We, constructed with the liquid density rho, the jet velocity u(o), and the surface tension sigma at the rim: D/d(o) = 1/8 We = 1/8 [rho u(o)(2)/(sigma/d(o))]. This relation expresses the equilibrium between inertial forces and surface tension forces at the sheet rim. When a surfactant has been dissolved in the bulk of the liquid prior to the formation of the initial jet, the rim surface tension, and therefore the sheet diameter, depends on the amount of surfactant adsorbed at the rim, This amount is fixed by a competition between surface formation induced by radial extension and repopulation of the liquid interface in surfactant, The experimental setup proposed here provides a method to measure dynamic surface tension from sheet diameter measurements and symmetrically to monitor the adsorption of a surfactant on a liquid surface. The available adsorption time ranges from 10 to 100 ms. Experimental data obtained with two surfactants are in agreement with a model of a diffusion-controlled adsorption at the interface, (C) 2000 Academic Press. Inst Mecan Grenoble, CNRS, LEGI, F-38041 Grenoble, France; Univ Aix Marseille 1, CNRS, UMR 6594, IRPHE,Serv 252, F-13397 Marseille 20, France; Univ Aix Marseille 2, CNRS, UMR 6594, IRPHE,Serv 252, F-13397 Marseille 20, France Communaute Universite Grenoble Alpes; Institut National Polytechnique de Grenoble; Universite Grenoble Alpes (UGA); Centre National de la Recherche Scientifique (CNRS); Centre National de la Recherche Scientifique (CNRS); Aix-Marseille Universite; Centre National de la Recherche Scientifique (CNRS); Aix-Marseille Universite Villermaux, E (corresponding author), Univ Aix Marseille 1, CNRS, UMR 6594, IRPHE,Serv 252, Campus St Jerome, F-13397 Marseille 20, France. Marmottant, Philippe/D-6808-2012 clanet, christophe/0000-0003-2448-0443; Villermaux, Emmanuel/0000-0001-5130-4862 [Anonymous], 1952, STAT THERMODYNAMICS; BLEYS G, 1985, J PHYS CHEM-US, V89, P1027, DOI 10.1021/j100252a028; Bond WN, 1937, PHILOS MAG, V24, P864; Defay R., 1958, J COLLOID SCI, V13, P553, DOI [10.1016/0095-8522(58)90066-7, DOI 10.1016/0095-8522(58)90066-7]; DEFAY R, 1959, J COLLOID SCI, V14, P411, DOI DOI 10.1016/0095-8522(59)90005-4; DUPRE A, 1869, THEORIE MECAN CHALEU; HANSEN RS, 1961, J COLL SCI IMP U TOK, V16, P549, DOI 10.1016/0095-8522(61)90043-5; Harkins WD, 1919, J AM CHEM SOC, V41, P499, DOI 10.1021/ja01461a003; HUANG JCP, 1970, J FLUID MECH, V43, P305, DOI 10.1017/S0022112070002392; JOOS P, 1982, J CHIM PHYS PCB, V79, P387, DOI 10.1051/jcp/1982790387; MCENTEE WR, 1969, J PHYS CHEM-US, V73, P3018, DOI 10.1021/j100843a042; PANDIT AB, 1990, J FLUID MECH, V212, P11, DOI 10.1017/S0022112090001823; POSNER AM, 1952, J COLL SCI IMP U TOK, V7, P623, DOI 10.1016/0095-8522(52)90044-5; RANZ WE, 1959, J APPL PHYS, V30, P1950, DOI 10.1063/1.1735095; RAYLEIGH JWS, 1879, P ROY SOC LOND A MAT, V71, P29; SAVART F, 1833, ANN CHIM PHYS, V59, P55; SAVART F., 1833, ANN CHIM PHYS, V54, P113; WARD AFH, 1946, J CHEM PHYS, V14, P453, DOI 10.1063/1.1724167; WILKINSON MC, 1972, J COLLOID INTERF SCI, V40, P14, DOI 10.1016/0021-9797(72)90169-5 19 22 22 1 21 ACADEMIC PRESS INC SAN DIEGO 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA 0021-9797 J COLLOID INTERF SCI J. Colloid Interface Sci. OCT 1 2000 230 1 29 40 10.1006/jcis.2000.7019 http://dx.doi.org/10.1006/jcis.2000.7019 12 Chemistry, Physical Science Citation Index Expanded (SCI-EXPANDED) Chemistry 361PX 10998285 2024-02-28 WOS:000089732400004
J Masuhara, A; Fujitsuka, M; Ito, O Masuhara, A; Fujitsuka, M; Ito, O Photoinduced electron-transfer of inclusion complexes of fullerenes (C60 and C70) in γ-cyclodextrin BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN English Article LASER FLASH-PHOTOLYSIS; WATER-SOLUBLE FULLERENE; CHARGE-TRANSFER COMPLEXES; EXCITED-STATE BEHAVIOR; CELL-CULTURE SYSTEM; NEAR-IR REGION; PULSE-RADIOLYSIS; PHOTOPHYSICAL PROPERTIES; TRIPLET-STATES; PHOTOCHEMICAL PROPERTIES Photophysical and photochemical properties of 1 :2 inclusion complexes of C-60 and C-70 in gamma -cyclodextrin (gamma -CD) have been studied by laser flash photolysis and steady photolysis methods. The triplet-triplet annihilations of C-60/gamma -CD and C-70/gamma -CD are retarded, compared with those of the pristine fullerenes. The rate constant for the fluorescence-quenching of C-70/gamma -CD by 1,4-diazabicyclo[2.2.2]octane was larger than that of C-60/gamma -CD, indicating incomplete hindrance by gamma -CD due to larger size of C-70 than C-60 A Similar trend was also observed in triplet-triplet annihilation processes of the encapsulated fullerenes. Generations of radical ions by photoinduced electron transfer between amines and C-3(60)*/gamma -CD or C-3(70)*/gamma -CD were confirmed by observing the transient absorption bands due to radical anions in the near-IR region. The electron transfer rates for C-3(60)*-CD or C-3(70)*/gamma -CD were slower than those of corresponding C-3(60)* Or C-3(70)* in solution by ca. 1/100. For reversible systems in which the cation radicals of amines are stable (for example, p-anisidine), C-60(.-)/gamma -CD and C-70*/gamma -CD decayed slowly by back electron transfer. For an irreversible system in which the cation radical of amine (nitrilotriethanol) is degraded, the high concentration of C-60*/gamma -CD or C-70(.-)/gamma -CD was persistent. On addition of methylviologen (MV2+), persistent MV.+ was generated in high concentration as equilibrium with C-60(.-)/gamma -CD, suggesting that C-60/gamma -CD acts as an efficient photosensitizer and an electron mediator to produce MV.+ using nitrilotriethanol as a sacrificial donor. Tohoku Univ, Inst Chem React Sci, Aoba Ku, Sendai, Miyagi 9808577, Japan Tohoku University Ito, O (corresponding author), Tohoku Univ, Inst Chem React Sci, Aoba Ku, Sendai, Miyagi 9808577, Japan. 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J Masyuk, TV; Ritman, EI; LaRusso, NF Masyuk, TV; Ritman, EI; LaRusso, NF Anatomical relationship of the hepatic artery to the intrahepatic biliary tree assessed by three-dimensional computer reconstruction. HEPATOLOGY English Meeting Abstract Mayo Med Sch, Clin & Fdn, Rochester, MN USA Mayo Clinic 0 1 1 0 0 W B SAUNDERS CO PHILADELPHIA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 USA 0270-9139 HEPATOLOGY Hepatology OCT 2000 32 4 2 2 163A 163A 1 Gastroenterology & Hepatology Science Citation Index Expanded (SCI-EXPANDED) Gastroenterology & Hepatology 359PZ 2024-02-28 WOS:000089622400004
J Mather, RR Mather, RR Evaluation by nitrogen adsorption of crystal aggregation in organic pigments DYES AND PIGMENTS English Article nitrogen adsorption; organic pigments; crystal aggregation; isotherm; surface area COPPER PHTHALOCYANINE PIGMENTS; HYSTERESIS Organic pigments consist of tiny molecular crystals with a propensity to cluster into aggregates. Such aggregation is commercially undesirable. The properties of the crystal aggregates can be investigated by the use of nitrogen adsorption isotherms. The review describes how a measure of the extent of crystal aggregation can be provided from the combined application of nitrogen isotherms and transmission electron microscopy. The application of full nitrogen isotherms to the study of crystal aggregation is also discussed. (C) 2000 Elsevier Science Ltd. All rights reserved. Heriot Watt Univ, Sch Text, Netherdale TD1 3HF, Galashiels, Scotland Heriot Watt University Mather, RR (corresponding author), Heriot Watt Univ, Sch Text, Netherdale TD1 3HF, Galashiels, Scotland. BAILEY A, 1971, T FARADAY SOC, V67, P231, DOI 10.1039/tf9716700231; Brunauer S, 1938, J AM CHEM SOC, V60, P309, DOI 10.1021/ja01269a023; CHUGHTAI IB, 1999, THESIS HERIOTWATT U; FRYER JR, 1981, J CHEM TECHNOL BIOT, V31, P371, DOI 10.1002/jctb.280310152; GREGG SJ, 1982, ADSORPTION SURFACE; HARRIS MR, 1965, CHEM IND-LONDON, P268; MATHER RR, 1981, CHEM IND-LONDON, P600; MATHER RR, 1991, COLLOID SURFACE, V58, P401, DOI 10.1016/0166-6622(91)80218-D; Mather RR, 1999, DYES PIGMENTS, V42, P103, DOI 10.1016/S0143-7208(99)00014-5; MATHER RR, 1994, CHARACTERIZATION POR, V3, P745; McKay R.B., 1981, DISPERSION POWDERS L, P471; MCKAY RB, 1987, COLLOID SURFACE, V27, P175, DOI 10.1016/0166-6622(87)80336-0; MCKAY RB, 1986, FATIPEC C 18, V2, P405; ROUQEROL F, 1999, ADSORPTION POWDERS 14 3 3 0 6 ELSEVIER SCI LTD OXFORD THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND 0143-7208 DYES PIGMENTS Dyes Pigment. OCT-NOV 2000 47 1-2 17 21 10.1016/S0143-7208(00)00059-0 http://dx.doi.org/10.1016/S0143-7208(00)00059-0 5 Chemistry, Applied; Engineering, Chemical; Materials Science, Textiles Science Citation Index Expanded (SCI-EXPANDED) Chemistry; Engineering; Materials Science 373VU 2024-02-28 WOS:000165311400004
J McDonald, KF; Blum, RS McDonald, KF; Blum, RS Exact performance of STAP algorithms with mismatched steering and clutter statistics IEEE TRANSACTIONS ON SIGNAL PROCESSING English Article adaptive arrays; adaptive radar; adaptive signal detection; mismatched statistics; space-time adaptive processing ADAPTIVE DETECTION ALGORITHM; CFAR; REJECTION; RADAR; SMI Adaptive algorithms for receivers employing antenna arrays have recently received significant attention for radar systems applications. In the majority of these algorithms, the covariance matrix for the clutter-plus-noise is characterized by using samples taken from range cells surrounding the test cell, If the underlying covariance matrix of the test cell is different from the average covariance matrix of the surrounding range cells, significant performance degradation may result. Exact expressions for performance are derived for such cases, when any of a set of popular space-time adaptive processing (STAP) algorithms are used, Numerical evaluation of these expressions illustrates how variations in the parameters of these equations affect probability of detection and probability of false alarm, The equations are utilized to determine an upper bound on the performance of this class of STAP algorithms. Mitre Corp, Bedford, MA 01730 USA; Lehigh Univ, Elect Engn & Comp Sci Dept, Bethlehem, PA 18015 USA MITRE Corporation; Lehigh University McDonald, KF (corresponding author), Mitre Corp, Burlington Rd, Bedford, MA 01730 USA. kfmcd@mitre.org; rblum@eecs.lehigh.edu Blum, Rick S/0000-0002-1024-6771 Antonik P, 1997, RADAR CONF, P372, DOI 10.1109/NRC.1997.588338; ANTONIK P, 1997, P 1997 INT RAD C OCT, P478; BORSARI GK, 1995, P 29 AS C SIGN SYST, V1, P650; BRENNAN LE, 1973, IEEE T AERO ELEC SYS, VAES9, P237, DOI 10.1109/TAES.1973.309792; CAI LJ, 1991, IEEE T AERO ELEC SYS, V27, P487, DOI 10.1109/7.81430; CAI LJ, 1994, IEEE T AERO ELEC SYS, V30, P1009, DOI 10.1109/7.328768; CHEN W, 1991, DIGIT SIGNAL PROCESS, V1, P198; CONTE E, 1995, IEEE T AERO ELEC SYS, V31, P617, DOI 10.1109/7.381910; GOODMAN NR, 1963, ANN MATH STAT, V34, P152, DOI 10.1214/aoms/1177704250; Johnson N. L., 1970, DISTRIBUTIONS STAT C, V2; KALSON SZ, 1992, IEEE T AERO ELEC SYS, V28, P195, DOI 10.1109/7.135445; KELLY EJ, 1989, IEEE T AERO ELEC SYS, V25, P122, DOI 10.1109/7.18674; KELLY EJ, 1986, IEEE T AERO ELEC SYS, V22, P115, DOI 10.1109/TAES.1986.310745; Kraut S, 1999, IEEE T SIGNAL PROCES, V47, P2538, DOI 10.1109/78.782198; KREITHEN DE, 1998, P 32 AS C SIGN SYST, V1, P528; McDonald KF, 1999, RADAR CONF, P267, DOI 10.1109/NRC.1999.767339; MCDONALD KF, 2000, THESIS LEHIGH U BETH; MCWHORTER L, 1996, P ASILOMAR 96 PAC GR, V1, P536; MELVIN W, 1997, P IEEE NAT RAD C SYR; Melvin WL, 1998, RADAR CONF, P171, DOI 10.1109/NRC.1998.677996; MELVIN WL, 1996, P 7 INT C SIGN PROC, P1479; MELVIN WL, 1996, P IASTED INT C SIGN; Muirhead R. J., 1982, Aspects of multivariate statistical theory.; REED IS, 1974, IEEE T AERO ELEC SYS, VAE10, P853, DOI 10.1109/TAES.1974.307893; Richmond CD, 1998, IEEE SIGNAL PROC LET, V5, P325, DOI 10.1109/97.735426; RICHMOND CD, 1998, P 9 IEEE STAT SIGN A, P65; RICHMOND CD, 1998, P 32 AS C SIGN SYST, V2, P1327; RICHMOND CD, 1998, P IEEE INT C AC SPEE, V4, P2005; ROBEY FC, 1992, IEEE T AERO ELEC SYS, V28, P208, DOI 10.1109/7.135446; Scharf L.L., 1990, Statistical Signal Processing; SCHARF LL, 1996, P 30 AS C SIGN SYST, V1, P1114; Shanmugan K.S., 1988, Random Signals: Detection, Estimation, and Data Analysis; WANG H, 1990, IEEE T AERO ELEC SYS, V26, P768, DOI 10.1109/7.102712; Wicks M., 1997, P 1997 INT RAD C ED, P295 34 36 36 0 2 IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PISCATAWAY 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA 1053-587X 1941-0476 IEEE T SIGNAL PROCES IEEE Trans. Signal Process. OCT 2000 48 10 2750 2763 10.1109/78.869025 http://dx.doi.org/10.1109/78.869025 14 Engineering, Electrical & Electronic Science Citation Index Expanded (SCI-EXPANDED) Engineering 358UK 2024-02-28 WOS:000089575400004
J Mcmahon, LP Mcmahon, LP Target haemoglobin levels for the treatment of the anaemia of chronic renal failure NEPHROLOGY English Review epoetin; haemoglobin; renal failure; target RECOMBINANT-HUMAN-ERYTHROPOIETIN; LEFT-VENTRICULAR HYPERTROPHY; QUALITY-OF-LIFE; HEMODIALYSIS-PATIENTS; HEMATOCRIT LEVELS; CARDIOVASCULAR MORTALITY; PHYSICAL PERFORMANCE; PERITONEAL-DIALYSIS; DISEASE THERAPY; ANEMIA Royal Melbourne Hosp, Dept Nephrol, Melbourne, Vic 3050, Australia Royal Melbourne Hospital Mcmahon, LP (corresponding author), Royal Melbourne Hosp, Dept Nephrol, Melbourne, Vic 3050, Australia. *AN WORK GROUP, 1997, NKF DOQI CLIN PRACT; ARINSOY T, 1992, NEPHRON, V62, P480, DOI 10.1159/000187110; AUNSHOLT NA, 1992, NEPHRON, V62, P284, DOI 10.1159/000187060; Benz RL, 1999, AM J KIDNEY DIS, V34, P1089, DOI 10.1016/S0272-6386(99)70015-6; Besarab A, 1998, NEW ENGL J MED, V339, P584, DOI 10.1056/NEJM199808273390903; BOOBES Y, 1997, NEPHROLOGY, V2, pS306; BURGESS ED, 1991, AM J NEPHROL, V11, P23, DOI 10.1159/000168267; CANAUD B, 1990, AM J KIDNEY DIS, V15, P169, DOI 10.1016/S0272-6386(12)80515-4; CHURCHILL DN, 1994, J AM SOC NEPHROL, V4, P1809; Collins AJ, 1998, NEPHROL DIAL TRANSPL, V13, P1627, DOI 10.1093/ndt/13.7.1627; Delano B G, 1990, ASAIO Trans, V36, P36; DeMarchi S, 1997, J AM SOC NEPHROL, V8, P1147; Eschbach J. W., 1993, Journal of the American Society of Nephrology, V4, P425; ESCHBACH JW, 1992, CLIN NEPHROL, V38, pS98; ESCHBACH JW, 1989, ANN INTERN MED, V111, P992, DOI 10.7326/0003-4819-111-12-992; Foley RN, 1996, AM J KIDNEY DIS, V28, P53, DOI 10.1016/S0272-6386(96)90130-4; FOLEY RN, 1995, KIDNEY INT, V47, P186, DOI 10.1038/ki.1995.22; Friedlander MA, 1997, SEMIN NEPHROL, V17, P331; HAMPL H, 1997, J AM SOC NEPHROL, V8, pA219; Ifudu O, 1996, NEW ENGL J MED, V334, P420, DOI 10.1056/NEJM199602153340702; Junor B J, 1993, Perit Dial Int, V13 Suppl 2, pS535; LAI KN, 1991, NEPHRON, V57, P394, DOI 10.1159/000186302; LAUDAT K, 1998, J AM SOC NEPHROL, V9, pA219; LAUPACIS A, 1990, BMJ-BRIT MED J, V300, P573; Levin A, 1996, AM J KIDNEY DIS, V27, P347, DOI 10.1016/S0272-6386(96)90357-1; LEVIN NW, 1994, AM J KIDNEY DIS, V24, P308, DOI 10.1016/S0272-6386(12)80196-X; Locatelli F, 1998, NEPHROL DIAL TRANSPL, V13, P1642, DOI 10.1093/ndt/13.7.1642; LUNDIN AP, 1989, SEMIN NEPHROL, V9, P22; Ma JZ, 1999, J AM SOC NEPHROL, V10, P610; MACDOUGALL IC, 1991, NEPHROL DIAL TRANSPL, V6, P862, DOI 10.1093/ndt/6.11.862; MACDOUGALL IC, 1990, LANCET, V335, P489, DOI 10.1016/0140-6736(90)90733-L; MASON K, 1997, NEPHROLOGY, V2, pS304; McMahon LP, 1999, NEPHROL DIAL TRANSPL, V14, P1182, DOI 10.1093/ndt/14.5.1182; MCMAHON LP, 1992, NEPHROL DIAL TRANSPL, V7, P1199, DOI 10.1093/ndt/7.12.1199; Metry G, 1999, J AM SOC NEPHROL, V10, P854; Moreno F, 1996, AM J KIDNEY DIS, V27, P548, DOI 10.1016/S0272-6386(96)90166-3; MUIRHEAD N, 1993, SEMIN DIALYSIS, V6, P184, DOI 10.1111/j.1525-139X.1993.tb00293.x; PASCUAL J, 1991, CLIN NEPHROL, V35, P280; Paulitschke M., 1997, Nephrology Dialysis Transplantation, V12, pA193; POLLOK M, 1989, CONTRIB NEPHROL, V76, P201; RAINE AEG, 1988, LANCET, V1, P97; REVICKI DA, 1995, AM J KIDNEY DIS, V25, P548, DOI 10.1016/0272-6386(95)90122-1; RITZ E, 1994, NEPHRON, V66, P125, DOI 10.1159/000187788; RODGERS GP, 1993, NEW ENGL J MED, V328, P73, DOI 10.1056/NEJM199301143280201; ROTH DA, 1997, J AM SOC NEPHROL, V8, pA170; *ROYAL COLL PHYS L, 1997, TREATM AD PAT REN FA; SHAND BI, 1993, NEPHRON, V64, P53, DOI 10.1159/000187278; SHINABERGER JH, 1988, T AM SOC ART INT ORG, V34, P179; TAYLOR JE, 1993, KIDNEY INT, V44, P182, DOI 10.1038/ki.1993.229; TEEHAN BP, 1991, AM J KIDNEY DIS, V18, P50; VALDERRABANO F, 1998, 2 EUR EP S OPT AN TH; Wakeen M, 1998, AM J KIDNEY DIS, V32, P488, DOI 10.1053/ajkd.1998.v32.pm9740167; WINEARLS CG, 1986, LANCET, V2, P1175, DOI 10.1016/S0140-6736(86)92192-6; WIRTZ JJJM, 1992, CLIN NEPHROL, V38, P277; WOODSON RD, 1984, AM REV RESPIR DIS, V129, pS72, DOI 10.1164/arrd.1984.129.2P2.S72; Xia H, 1999, J AM SOC NEPHROL, V10, P1309 56 0 0 0 2 WILEY HOBOKEN 111 RIVER ST, HOBOKEN 07030-5774, NJ USA 1320-5358 1440-1797 NEPHROLOGY Nephrology OCT 2000 5 3 161 165 10.1046/j.1440-1797.2000.00006.x http://dx.doi.org/10.1046/j.1440-1797.2000.00006.x 5 Urology & Nephrology Science Citation Index Expanded (SCI-EXPANDED) Urology & Nephrology 383XF Bronze 2024-02-28 WOS:000165909400004
J Merloni, A; Di Matteo, T; Fabian, AC Merloni, A; Di Matteo, T; Fabian, AC Magnetic flares and the optical variability of the X-ray transient XTE J1118+480 MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY English Article accretion, accretion discs; magnetic fields; radiation mechanisms : thermal; binaries : general; stars : individual : XTE J1118+480 ADVECTION-DOMINATED ACCRETION; QUASI-PERIODIC OSCILLATION; ACTIVE GALACTIC NUCLEI; BLACK-HOLES; CORONAE; GX339-4; DISKS; FREQUENCIES; PRECESSION; BINARIES The simultaneous presence of a strong quasi-periodic oscillation, of period similar to 10 s, in the optical and X-ray light curves of the X-ray transient XTE J1118+480 suggests that a significant fraction of the optical flux originates from the inner part of the accretion flow, where most of the X-rays are produced. We present a model of magnetic flares in an accretion disc corona where thermal cyclo-synchrotron emission contributes significantly to the optical emission, while the X-rays are produced by inverse Compton scattering of the soft photons produced by dissipation in the underlying disc and by the synchrotron process itself. Given the observational constraints, we estimate the values for the coronal temperature, optical depth and magnetic field intensity, as well as the accretion rate for the source. Within our model we predict a correlation between optical and hard X-ray variability and an anticorrelation between optical and soft X-rays. We also expect optical variability on flaring time-scales (similar to tens of ms), with a power-density spectrum similar to that observed in the X-ray band. Finally, we use both the available optical/extreme-ultraviolet/X-ray spectral energy distribution and the low-frequency time variability to discuss limits on the inner radius of the optically thick disc. Univ Cambridge, Inst Astron, Cambridge CB3 0HA, England; Harvard Smithsonian Ctr Astrophys, Cambridge, MA 02138 USA University of Cambridge; Harvard University; Smithsonian Astrophysical Observatory; Smithsonian Institution Merloni, A (corresponding author), Univ Cambridge, Inst Astron, Madingley Rd, Cambridge CB3 0HA, England. DiMatteo, Tiziana/O-4762-2014 DiMatteo, Tiziana/0000-0002-6462-5734 Balbus SA, 1998, REV MOD PHYS, V70, P1, DOI 10.1103/RevModPhys.70.1; Beloborodov AM, 1999, ASTROPHYS J, V510, pL123, DOI 10.1086/311810; Di Matteo T, 1999, ASTROPHYS J, V526, pL101, DOI 10.1086/312369; Di Matteo T, 1998, MON NOT R ASTRON SOC, V299, pL15, DOI 10.1046/j.1365-8711.1998.01950.x; Di Matteo T, 1999, MON NOT R ASTRON SOC, V304, P809, DOI 10.1046/j.1365-8711.1999.02375.x; DiMatteo T, 1997, MON NOT R ASTRON SOC, V291, P805, DOI 10.1093/mnras/291.4.805; DiMatteo T, 1997, MON NOT R ASTRON SOC, V291, pL23, DOI 10.1093/mnras/291.1.L23; Done C, 1999, MON NOT R ASTRON SOC, V305, P457, DOI 10.1046/j.1365-8711.1999.02439.x; Esin AA, 1998, ASTROPHYS J, V505, P854, DOI 10.1086/306186; FABIAN AC, 1982, ASTRON ASTROPHYS, V111, pL9; GALEEV AA, 1979, ASTROPHYS J, V229, P318, DOI 10.1086/156957; GARCIA M, 2000, 7392 IAU; Gierlinski M, 1997, MON NOT R ASTRON SOC, V288, P958, DOI 10.1093/mnras/288.4.958; Haardt F., 1994, APJ, V432, P95; HASWELL CA, 2000, 742 IAU; HASWELL CA, 2000, 7427 IAU; Hynes RI, 2000, ASTROPHYS J, V539, pL37, DOI 10.1086/312836; Merloni A, 1999, MON NOT R ASTRON SOC, V304, P155, DOI 10.1046/j.1365-8711.1999.02307.x; Miller KA, 2000, ASTROPHYS J, V534, P398, DOI 10.1086/308736; MOTCH C, 1983, ASTRON ASTROPHYS, V119, P171; NARAYAN R, 1995, ASTROPHYS J, V452, P710, DOI 10.1086/176343; NOWAK MA, 2000, IN PRESS MNRAS; PATTERSON J, 2000, 7413 IAU; Poutanen J, 1998, PHYS SCRIPTA, VT77, P57, DOI 10.1088/0031-8949/1998/T77/014; Psaltis D, 1999, ASTROPHYS J, V520, P262, DOI 10.1086/307436; PSALTIS D, 2000, IN PRESS APJ; Quataert E, 1999, ASTROPHYS J, V520, P298, DOI 10.1086/307439; REMILLARD R, 2000, 7389 IAU; REVNIVTSEV M, 2000, UNPUB A A; Stella L, 1999, ASTROPHYS J, V524, pL63, DOI 10.1086/312291; UEMURA M, 2000, 7390 IAU; Wardzinski G, 2000, MON NOT R ASTRON SOC, V314, P183, DOI 10.1046/j.1365-8711.2000.03297.x; Wijnands R, 1999, ASTROPHYS J, V514, P939, DOI 10.1086/306993; Wilms J, 1999, ASTROPHYS J, V522, P460, DOI 10.1086/307622; WILSON CA, 2000, 7390 IAU; Zdziarski AA, 1998, MON NOT R ASTRON SOC, V301, P435, DOI 10.1046/j.1365-8711.1998.02021.x 36 51 52 0 1 BLACKWELL SCIENCE LTD OXFORD P O BOX 88, OSNEY MEAD, OXFORD OX2 0NE, OXON, ENGLAND 0035-8711 MON NOT R ASTRON SOC Mon. Not. Roy. Astron. Soc. OCT 2000 318 1 L15 L19 10.1046/j.1365-8711.2000.03943.x http://dx.doi.org/10.1046/j.1365-8711.2000.03943.x 5 Astronomy & Astrophysics Science Citation Index Expanded (SCI-EXPANDED) Astronomy & Astrophysics 363VB Green Submitted 2024-02-28 WOS:000089857400004
J Metzler, B; von Erffa, R Metzler, B; von Erffa, R On the distribution of Nectria canker of beech in natural regenerations - Influence of shelterwood and site factors FORSTWISSENSCHAFTLICHES CENTRALBLATT German Article Fagus sylvatica; Nectria ditissima; forest pathology; wood quality; silviculture The distribution of Leech canker was surveyed in the natural regeneration of ill beech stands in 11 forest districts of Baden-Wurttemberg. 801 sample plots comprising some 60,000 tree individuals were monitored. Beech canker was found in each forest district and in 75 % of the stands. However, the disease incidence rarely reached a level of economical importance. The natural regeneration was significantly more affected by beech canker when growing under a diseased beech shelterwood. However, the impact of the density of the canopy itself, presumably corresponding with light intensity, was nor evident. In mixed stands the disease incidence was lower than in pure beech stands. Forest stands at lower altitudes (up to ca. 450m above sea level) were more affected. Correspondingly, disease incidence more than tripled in the warmer and dryer areas. Forstl Versuchs & Forsch Anstalt Baden Wurtemberg, Abt Waldschutz, D-79100 Freiburg, Germany Metzler, B (corresponding author), Forstl Versuchs & Forsch Anstalt Baden Wurtemberg, Abt Waldschutz, Wonnhaldestr 4, D-79100 Freiburg, Germany. [Anonymous], 1977, FICHTE; Bastien Y., 1997, Revue Forestiere Francaise (Nancy), V49, P49; BORRMANN K., 1994, WALD, V44, P15; BOSSHARD HH, 1965, Z FORSTWESEN, V116, P1; Burschel P., 1987, GRUNDRISS WALDBAUS; BUTIN H, 1996, KRANKHEITEN WALD PAR; DIMITRI L., 1967, Forstwissenschaftliches Zentralblatt, V86, P257, DOI 10.1007/BF01821835; Hartig R., 1882, Lehrbuch der Baumkrankheiten; Klein E., 1997, Forst und Holz, V52, P58; *LFV, 1997, LAND BAD WURTT, pS7; LIESE J, 1928, FORSTARCHIV, V4, P292; Perrin R., 1981, Schweizerische Zeitschrift fur Forstwesen, V132, P1; PERRIN R, 1978, ANN SCI FOREST, V35, P213, DOI 10.1051/forest/19780304; Perrin R., 1976, Bulletin Trimestriel de la Societe Mycologique de France, V92, P335; Rao C. R., 1965, LINEAR STAT INFERENC; REINDL J, 1996, AFZ, V51, P359; RICHTER HARALD, 1928, ZEITSCHR WISS BIOL ABT F ZEITSCHR PARASITENK, V1, P24, DOI 10.1007/BF02119416; Sachs L, 1984, ANGEW STAT; SAGHEBTALEI K, 1996, BEIHEFT SCHWEIZ Z FO, V78; SCHUTT P, 1980, WALDSCHUTZMERKBLATT, V1; VANGERWEN CP, 1980, NEDERLANDS BOWBOUW T, V52, P1; VELDMANN G, 1984, BIBLIO MITTEILUNGEN, V24; VERNIER F., 1979, REV FOREST FR, V29, P286 23 6 9 0 5 BLACKWELL WISSENSCHAFTS-VERLAG GMBH BERLIN KURFURSTENDAMM 57, D-10707 BERLIN, GERMANY 0015-8003 FORSTWISS CENTRALBL Forstwiss. Cent.bl. OCT 2000 119 5 297 309 10.1007/BF02769144 http://dx.doi.org/10.1007/BF02769144 13 Forestry Science Citation Index Expanded (SCI-EXPANDED) Forestry 372YJ 2024-02-28 WOS:000165261400004
J Meyerheim, HL; Gloege, T; Sokolowski, M; Umbach, E; Bäuerle, P Meyerheim, HL; Gloege, T; Sokolowski, M; Umbach, E; Bäuerle, P Adsorption-induced distortion of a large π-conjugated molecule studied by surface X-ray diffraction:: End-capped quaterthiophene on Ag(111) EUROPHYSICS LETTERS English Article LARGE ORGANIC ADSORBATES; ULTRAHIGH-VACUUM; OLIGOTHIOPHENES; BENZENE; IMAGES The internal geometric structure of a large pi -conjugated organic molecule adsorbed on a metallic surface (end-capped quaterthiophene on Ag(111)) was determined in detail by using surface X-ray diffraction. In contrast to the common belief that such molecules remain undistorted on a weakly interacting substrate, we find significant distortion of the thiophene rings and elongation of the bond distances. These results open new perspectives for the understanding of large organic adsorbates and have important implications for a deeper insight into organic/inorganic interfaces in general. Univ Munich, Inst Kristallog & Angew Minerol, D-80333 Munich, Germany; Univ Wurzburg, D-97074 Wurzburg, Germany; Univ Ulm, Abt Organ Chem 2, D-89081 Ulm, Germany University of Munich; University of Wurzburg; Ulm University Meyerheim, HL (corresponding author), Max Planck Inst Mikrostrukturphys, Weinberg 2, D-06120 Halle, Germany. Meyerheim, Holger/0000-0002-1448-4793 ARVANITIS D, 1987, PHYS REV LETT, V59, P2435, DOI 10.1103/PhysRevLett.59.2435; AVOURIS P, 1981, J CHEM PHYS, V75, P4783, DOI 10.1063/1.441914; BAUERLE P, 1992, ADV MATER, V4, P102, DOI 10.1002/adma.19920040209; FEIDENHANSL R, 1989, SURF SCI REP, V10, P105, DOI 10.1016/0167-5729(89)90002-2; Ferry D, 1997, PHYS REV LETT, V78, P4237, DOI 10.1103/PhysRevLett.78.4237; Forrest SR, 1997, CHEM REV, V97, P1793, DOI 10.1021/cr941014o; GARNIER F, 1994, SCIENCE, V265, P1684, DOI 10.1126/science.265.5179.1684; GEBAUER W, UNPUB; HALLMARK VM, 1993, PHYS REV LETT, V70, P3740, DOI 10.1103/PhysRevLett.70.3740; KRETSCHMAR F, 1987, Z KRISTALLOGR, V178, P130; MAINKA C, 1995, SURF SCI, V341, pL1055, DOI 10.1016/0039-6028(95)00795-4; MITSCHKE U, UNPUB; ROBINSON IK, 1991, HDB SYNCHROTRON RAD, V3; SCHAMPER C, 1993, J APPL CRYSTALLOGR, V26, P687, DOI 10.1107/S0021889893004364; Seidel C, 1997, SURF SCI, V374, P17, DOI 10.1016/S0039-6028(96)01186-7; Seki K, 1998, J ELECTRON SPECTROSC, V88, P821, DOI 10.1016/S0368-2048(97)00168-0; Sheldrick G., SHELX 97; Siegrist T, 1998, ADV MATER, V10, P379, DOI 10.1002/(SICI)1521-4095(199803)10:5<379::AID-ADMA379>3.0.CO;2-A; Soukopp A, 1998, PHYS REV B, V58, P13882, DOI 10.1103/PhysRevB.58.13882; UCHIYAMA K, 1994, SYNTHETIC MET, V63, P57, DOI 10.1016/0379-6779(94)90249-6; UMACH E, 1996, APPL PHYS A, V63, P565; Umbach E, 1998, J LUMIN, V76-7, P641, DOI 10.1016/S0022-2313(97)00170-1; Umbach E, 1998, SURF SCI, V402, P20, DOI 10.1016/S0039-6028(98)00014-4; WEISS PS, 1993, PHYS REV LETT, V71, P3139, DOI 10.1103/PhysRevLett.71.3139; Yoshinobu J, 1997, PHYS REV LETT, V79, P3942, DOI 10.1103/PhysRevLett.79.3942; ZANOTTI G, 1992, FUNDAMENTALS CRYSTAL, V2 26 12 12 0 7 E D P SCIENCES LES ULIS CEDEXA 7, AVE DU HOGGAR, PARC D ACTIVITES COURTABOEUF, BP 112, F-91944 LES ULIS CEDEXA, FRANCE 0295-5075 EUROPHYS LETT Europhys. Lett. OCT 2000 52 2 144 150 10.1209/epl/i2000-00416-x http://dx.doi.org/10.1209/epl/i2000-00416-x 7 Physics, Multidisciplinary Science Citation Index Expanded (SCI-EXPANDED) Physics 365FK 2024-02-28 WOS:000089938400004
J Min, G; Christensen, S; Marcussen, N; Osterby, R Min, G; Christensen, S; Marcussen, N; Osterby, R Glomerular structure in lithium-induced chronic renal failure in rats APMIS English Article ACE-inhibitor treatment; chronic renal failure; glomerular morphology; glomerular volume; lithium intoxication; stereology INDUCED CHRONIC NEPHROPATHY; ATUBULAR GLOMERULI; HYPERTENSION; PROGRESSION; ENALAPRIL; INJURY; KIDNEY; CELLS; MODEL The effects of long-term lithium administration on glomerular structure and intervention with angiotensin converting enzyme inhibitor (ACEI) were studied in rats. Male Wistar rats were fed a lithium-containing diet (Li) or control diet (C) for 16 weeks postnatally. Li-treated rats developed renal failure, hypertension and proteinuria. During the subsequent 24 weeks, subgroups were treated with ACEI. The kidneys were fixed by perfusion, and tissue blocks were serially cut for estimation of glomerular volume and glomerular characteristics by light microscopy. Mesangial and mesangial matrix volume fractions, surface density of capillary walls, basement membrane thickness and foot process width (FPW) were measured by electron microscopy. Glomerular volume was decreased in Li-rats, with increased intra-individual variation. In all Li-rats, some glomeruli (mean 27%) were abnormal, with severe changes in only three rats. Ultrastructural parameters obtained by systematic sampling of three glomeruli in each rat showed no differences among groups. Among Li-treated animals there was a significant correlation between FPW and albumin excretion per unit filtration surface, and between filtration surface per glomerulus and inulin clearance. In conclusion, long-term lithium administration to newborn rats caused marked changes in glomerular volume which were not associated with measurable changes in structural parameters. No effect of ACEI-treatment was detectable. Univ Aarhus, Inst Expt Clin Res, Electron Microscopy Lab, DK-8000 Aarhus C, Denmark; Univ Aarhus, Inst Pathol, DK-8000 Aarhus C, Denmark; Univ Copenhagen, Dept Pharmacol, DK-1168 Copenhagen, Denmark Aarhus University; Aarhus University; University of Copenhagen Osterby, R (corresponding author), Aarhus Kommune Hosp, Electron Microscopy Lab, Bldg 03, DK-8000 Aarhus C, Denmark. RO@EM.AU.DK BJORN SF, 1995, DIABETOLOGIA, V38, P1197, DOI 10.1007/BF00422369; Boner G, 1996, DIABETOLOGIA, V39, P587; BRENNER BM, 1994, AM J KIDNEY DIS, V23, P171, DOI 10.1016/S0272-6386(12)80967-X; Burton CJ, 1999, NEPHROL DIAL TRANSPL, V14, P2628, DOI 10.1093/ndt/14.11.2628; Christensen S, 1997, PHARMACOL TOXICOL, V80, P132, DOI 10.1111/j.1600-0773.1997.tb00386.x; CHRISTENSEN S, 1992, RENAL PHYSIOL BIOCH, V15, P141; CHRISTENSEN S, 1983, PFLUG ARCH EUR J PHY, V399, P208, DOI 10.1007/BF00656716; CHRISTENSEN S, 1982, ACTA PATH MICRO IM A, V90, P257; DECOURTEN M, 1994, AM J HYPERTENS, V7, pS84; DORUP J, 1988, J ULTRA MOL STRUCT R, V100, P212, DOI 10.1016/0889-1605(88)90038-9; FAWCETT JK, 1960, J CLIN PATHOL, V13, P156, DOI 10.1136/jcp.13.2.156; GUNDERSEN HJG, 1988, APMIS, V96, P379, DOI 10.1111/j.1699-0463.1988.tb05320.x; HIROSE K, 1982, KIDNEY INT, V21, P689, DOI 10.1038/ki.1982.82; Ishidoya S, 1996, KIDNEY INT, V49, P1110, DOI 10.1038/ki.1996.161; JACKSON B, 1986, CLIN EXP PHARMACOL P, V13, P319, DOI 10.1111/j.1440-1681.1986.tb00356.x; JENSEN EB, 1979, J MICROSC-OXFORD, V115, P19, DOI 10.1111/j.1365-2818.1979.tb00149.x; KAGAMI S, 1994, J CLIN INVEST, V93, P2431, DOI 10.1172/JCI117251; KAMPER AL, 1992, AM J HYPERTENS, V5, P423, DOI 10.1093/ajh/5.7.423; KLAHR S, 1988, NEPHROLOGY, V2, P1182; LOWRY OH, 1951, J BIOL CHEM, V193, P265; MARCUSSEN N, 1992, LAB INVEST, V66, P265; MARCUSSEN N, 1990, VIRCHOWS ARCH A, V417, P513, DOI 10.1007/BF01625732; Marcussen N, 1995, Curr Top Pathol, V88, P145; MARCUSSEN N, 1989, LAB INVEST, V61, P295; MATHIESEN ER, 1998, NEPHROL DIAL TRANSPL, V13, P1062; MEYER TW, 1987, KIDNEY INT, V31, P752, DOI 10.1038/ki.1987.62; Muller GA, 1996, KIDNEY INT, V49, pS75; Nielsen SH, 1997, ACTA PHYSIOL SCAND, V160, P301, DOI 10.1046/j.1365-201X.1997.00162.x; Noda M, 1997, KIDNEY INT, pS136; OSTERBY R, 1980, DIABETOLOGIA, V18, P493; Ruggenenti P, 1997, Kidney Int Suppl, V63, pS54; SEEFELDT T, 1981, LAB INVEST, V44, P541; Tikkanen I, 1997, KIDNEY INT, pS19; TOLINS JP, 1990, KIDNEY INT, V38, pS118; Viberti G, 1997, KIDNEY INT, pS32 35 2 3 0 3 WILEY HOBOKEN 111 RIVER ST, HOBOKEN 07030-5774, NJ USA 0903-4641 1600-0463 APMIS APMIS OCT 2000 108 10 652 662 10.1034/j.1600-0463.2000.d01-12.x http://dx.doi.org/10.1034/j.1600-0463.2000.d01-12.x 11 Immunology; Microbiology; Pathology Science Citation Index Expanded (SCI-EXPANDED) Immunology; Microbiology; Pathology 388PX 11200820 2024-02-28 WOS:000166191400004
J Mirza, S; Malik, TH; Ahmed, A; Willatt, DJ; Hughes, DG Mirza, S; Malik, TH; Ahmed, A; Willatt, DJ; Hughes, DG Incidental findings on magnetic resonance imaging screening for cerebellopontine angle tumours JOURNAL OF LARYNGOLOGY AND OTOLOGY English Article magnetic resonance imaging; cerebellopontine angle; pathology INFERIOR CEREBELLAR ARTERY; CARDIOVASCULAR HEALTH; CRANIAL NERVE; MR; BRAIN; ABNORMALITIES; COMPRESSION; PROTOCOL; DISEASE The otolaryngologist who requests magnetic resonance imaging (MRI) scans to exclude cerebellopontine angle (CPA) tumours may discover incidental pathologies. We retrospectively reviewed the results of 644 consecutive MRI screening scans with the aim of identifying findings other than CPA tumours. Two hundred and eighty-nine (45 per cent) scans featured one or more anomalies or abnormalities, including CPA tumour (23, four per cent), vascular loop (30, five per cent), basilar artery ectasia (13, two per cent), multiple high signal areas (135, 21 per cent), brain atrophy (52, eight per cent), sinus findings (56, nine per cent), middle ear/mastoid disease (34, five per cent), and a variety of other findings (39, six per cent) including clinically serious lesions (11, two per cent). The significance and management of these incidental findings is discussed. The majority were not clinically significant but the occasional presence of a serious incidental pathology should be borne in mind. Basilar artery ectasia and multiple high signal areas may be responsible for the symptoms investigated by MRI, and screening for cerebrovascular disease risk factors in such patients may be appropriate. Hope Hosp, Dept Otolaryngol, Salford M6 8HD, Lancs, England; Hope Hosp, Dept Neuroradiol, Salford M6 8HD, Lancs, England Mirza, S (corresponding author), 7 Cemetery Rd, Royton OL2 5SP, Oldham, England. APPLEBAUM EL, 1984, ANN OTO RHINOL LARYN, V93, P63, DOI 10.1177/00034894840930S412; AWAD IA, 1987, NEUROSURGERY, V20, P222, DOI 10.1227/00006123-198702000-00004; BRYAN RN, 1994, AM J NEURORADIOL, V15, P1625; DeCarpentier J, 1996, CLIN OTOLARYNGOL, V21, P312; FAZEKAS F, 1993, NEUROLOGY, V43, P1683, DOI 10.1212/WNL.43.9.1683; FLINN J, 1994, CLIN OTOLARYNGOL, V19, P287, DOI 10.1111/j.1365-2273.1994.tb01232.x; JANNETTA PJ, 1980, ANN SURG, V192, P518, DOI 10.1097/00000658-198010000-00010; Kirsch E, 1996, ACTA NEUROCHIR, V138, P1295, DOI 10.1007/BF01411058; LECLERCQ TA, 1980, LARYNGOSCOPE, V90, P1011; MARTIN RG, 1980, NEUROSURGERY, V6, P483, DOI 10.1227/00006123-198005000-00001; MAZZONI A, 1970, ARCHIV OTOLARYNGOL, V91, P128; OAS JG, 1992, NEUROLOGY, V42, P2274, DOI 10.1212/WNL.42.12.2274; Ouaknine G E, 1982, Adv Otorhinolaryngol, V28, P121; PETERSON NT, 1977, RADIOLOGY, V122, P713, DOI 10.1148/122.3.713; RAO KG, 1979, AM J ROENTGENOL, V132, P672, DOI 10.2214/ajr.132.4.672; REISSER C, 1991, LARYNGOSCOPE, V101, P761; ROBSON AK, 1993, J ROY SOC MED, V86, P455; SAEED SR, 1995, BRIT J NEUROSURG, V9, P497, DOI 10.1080/02688699550041133; SHALIT MN, 1978, SURG NEUROL, V10, P337; Sheppard IJ, 1996, CLIN OTOLARYNGOL, V21, P301, DOI 10.1111/j.1365-2273.1996.tb01074.x; YETKIN FZ, 1991, RADIOLOGY, V178, P447, DOI 10.1148/radiology.178.2.1987607; Yue NC, 1997, RADIOLOGY, V202, P41, DOI 10.1148/radiology.202.1.8988190 22 27 29 0 1 CAMBRIDGE UNIV PRESS CAMBRIDGE EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND 0022-2151 1748-5460 J LARYNGOL OTOL J. Laryngol. Otol. OCT 2000 114 10 750 754 5 Otorhinolaryngology Science Citation Index Expanded (SCI-EXPANDED) Otorhinolaryngology 378WM 11127143 2024-02-28 WOS:000165608400004
J Miyazaki, M Miyazaki, M Mechanized production system for orchards on sloping land in Japan JARQ-JAPAN AGRICULTURAL RESEARCH QUARTERLY English Article farm path; pest control; transportation; fertilizer application In Japan, most of the farm operations in orchards on sloping land in the past had been carried out manually, since no suitable machinery was available. However presently, the problem of aging farmers and shortage of young successors, especially for citrus orchards on steep hillsides must be solved. Therefore, a mechanized production system (MPS) for orchards on sloping land was developed involving the construction of farm paths and the use of machines behind which the operator walks, such as air-blast sprayer, raised bed transporter, and fertilizer spreader. The benefits of MPS were confirmed by comparison with a conventional production system (CPS) in an actual farmer's orchard at Yoshida town, Ehime prefecture, which is one of the leading citrus-production districts in Japan. The use of this system enabled to reduce the total working hours by 35% as well as improve the working conditions without yield decrease and decline of the quality of fruits. Dept Hilly Land Agr, Shikoku Natl Agr Expt Stn, Kagawa 7650053, Japan Miyazaki, M (corresponding author), Natl Res Inst Vegetables Ornamental Plants & Tea, Dept Tea Agron, 2769 Kanaya, Shizuoka 4288501, Japan. MIYAZAKI M, 1999, JPN J FARM WORK RES, V34, P85; MIYAZAKI M, 1998, FOOD FERT TECHNOL CE, V452, P1; MIYAZAKI M, 1999, JPN J FARM WORK RES, V34, P191; MIYAZAKI M, 1999, JPN J FARM WORK RES, V34, P203; OKAZAKI K, 1998, JPN J FARM WORK RES, V33, P213 5 1 1 0 5 TROPICAL AGRICULTURE RES CENTR TSUKUBA IBARAKI MINISTRY OF AGRICULTURE FORESTRY AND FISHERIES YATABE, TSUKUBA IBARAKI, 305, JAPAN 0021-3551 JARQ-JPN AGR RES Q Jarq - Jpn. Agric. Res. Q. OCT 2000 34 4 239 245 7 Agriculture, Multidisciplinary Science Citation Index Expanded (SCI-EXPANDED) Agriculture 383JY 2024-02-28 WOS:000165880400004
J Moon, SK; Lim, DJ; Lee, HK; Kim, HN; Yoon, JH Moon, SK; Lim, DJ; Lee, HK; Kim, HN; Yoon, JH Mucin gene expression in cultured human middle ear epithelial cells ACTA OTO-LARYNGOLOGICA English Article cell culture; human; middle ear epithelial cell; mucin gene; vimentin VIMENTIN EXPRESSION; IDENTIFICATION; TRANSPORT; CDNA For the advanced study of the cell and molecular biology of middle car mucosa, an in vitro cell culture system is required. Although middle ear epithelial cells have been cultured from various species of laboratory animal, there have been no reports concerning a serial subculture system of human middle ear epithelial cells. Tn this paper, we describe the establishment of a primary culture system of human middle ear epithelial cells using a serum-free conditioned medium and the characterization of these cells by the expression of phenotypic characteristics of epithelial cells and mucin genes. Cultured cells were anchorage-dependent ill terms of growth and showed a polygonal cobblestone-like appearance: desmosomes in the cell junction were observed by electron microscopy. In the immunocytochemical study, cytokeratin (epithelial cell marker) was expressed in all cultured cells, but von Willebrand factor (endothelial cell marker) was not. Unexpectedly. vimentin (fibroblast marker) was focally expressed, and a double stain showed the co-expression of both cytokeratin and vimentin in the same cell. The products of reverse transcriptase polymerase chain reaction from cultured cells yielded distinct bands compatible with the expected sizes of the MUC1, MUC2, MUC5AC and MUC5B genes. This culture system will allow us to prepare the cell line and to perform advanced studies of human middle ear mucosal biology. Yonsei Univ, Coll Med, Dept Otorhinolaryngol, Seoul 120752, South Korea; Yonsei Univ, Coll Med, BK21 Project Med Sci, Seoul 120752, South Korea; House Ear Res Inst, Dept Cell & Mol Biol, Los Angeles, CA USA Yonsei University; Yonsei University Health System; Yonsei University; Yonsei University Health System; House Research Institute Yoon, JH (corresponding author), Yonsei Univ, Coll Med, Dept Otorhinolaryngol, 134 Shinchon Sudaemun, Seoul 120752, South Korea. jhyoon@yumc.yonsei.ac.kr Yoon, Joo-Heon/E-5781-2016; Lim, DJ/JED-5922-2023 Yoon, Joo-Heon/0000-0003-2404-7156 Buisine MP, 1998, BIOCHEM J, V332, P729, DOI 10.1042/bj3320729; CHUN YM, 1999, 7 INT S REC ADV OT M; DAIRKEE SH, 1985, IN VITRO CELL DEV B, V21, P321; DEJONG PM, 1993, IN VITRO CELL DEV-AN, V29A, P379, DOI 10.1007/BF02633985; DRUCKER I, 1976, ANN OTO RHINOL LARYN, V85, P327, DOI 10.1177/000348947608500303; FRESHNEY RI, 1994, CULTURE ANIMAL CELLS, P127; Gray TE, 1996, AM J RESP CELL MOL, V14, P104, DOI 10.1165/ajrcmb.14.1.8534481; GUM JR, 1994, J BIOL CHEM, V269, P2440; HERMAN P, 1993, J CELL PHYSIOL, V154, P615, DOI 10.1002/jcp.1041540321; HERMAN P, 1992, AM J PHYSIOL, V262, pF373, DOI 10.1152/ajprenal.1992.262.3.F373; HILL J, 1992, CLIN OTOLARYNGOL, V17, P491, DOI 10.1111/j.1365-2273.1992.tb01703.x; Hutton David A., 1998, Biochemical Society Transactions, V26, pS117; Jin SJ, 1999, ANN OTO RHINOL LARYN, V108, P934, DOI 10.1177/000348949910801003; Lin JZ, 1999, ANN OTO RHINOL LARYN, V108, P762, DOI 10.1177/000348949910800809; MORK C, 1990, DIFFERENTIATION, V43, P146; NAKAMURA A, 1991, ANN OTO RHINOL LARYN, V100, P1024, DOI 10.1177/000348949110001212; NAKAMURA A, 1993, ACTA OTO-LARYNGOL, P75; NAKAMURA A, 1991, ANN OTO RHINOL LARYN, V100, P774, DOI 10.1177/000348949110000916; Nell MJ, 1999, ORL-J OTO-RHIN-LARYN, V61, P201, DOI 10.1159/000027671; RICHARD MH, 1990, ARCH DERMATOL RES, V282, P512, DOI 10.1007/BF00371945; SCHOUSBOE LP, 1995, ACTA OTO-LARYNGOL, V115, P787, DOI 10.3109/00016489509139403; SUGGS SV, 1981, P NATL ACAD SCI-BIOL, V78, P6613, DOI 10.1073/pnas.78.11.6613; SWIERENGA SHH, 1984, EXP CELL RES, V153, P39, DOI 10.1016/0014-4827(84)90446-4; TAKENO S, 1993, J OTOLARYNGOL, V22, P380; TSARFATY I, 1990, GENE, V93, P313, DOI 10.1016/0378-1119(90)90242-J; VANBLITTERSWIJK CA, 1986, ACTA OTO-LARYNGOL, V101, P453, DOI 10.3109/00016488609108632; WHITCUTT MJ, 1988, IN VITRO CELL DEV B, V24, P420; Yoon JH, 2000, ANN OTO RHINOL LARYN, V109, P594, DOI 10.1177/000348940010900612 28 20 21 0 5 TAYLOR & FRANCIS LTD ABINGDON 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND 0001-6489 1651-2251 ACTA OTO-LARYNGOL Acta Oto-Laryngol. OCT 2000 120 8 933 939 10.1080/00016480050218654 http://dx.doi.org/10.1080/00016480050218654 7 Otorhinolaryngology Science Citation Index Expanded (SCI-EXPANDED) Otorhinolaryngology 391WC 11200587 2024-02-28 WOS:000166378400004
J Moser, J; Boscá, F; Lovell, WW; Castell, JV; Miranda, MA; Hye, A Moser, J; Boscá, F; Lovell, WW; Castell, JV; Miranda, MA; Hye, A Photobinding of carprofen to protein JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY English Article albumin; carbazole; carprofen; dehalogenation; fluorescence; photobinding; photolysis ANTIINFLAMMATORY DRUGS; TIAPROFENIC ACID; PHOTOTOXICITY; INVITRO; DERMATITIS; MECHANISM; BINDING; ALBUMIN Carprofen is a non-steroidal antiinflammatory drug with marked photosensitising properties. In order to elucidate the mechanisms underlying the phenomenon of drug-protein photobinding, mixtures of the drug and human serum albumin were irradiated under different experimental conditions. After irradiation and subsequent gel-filtration chromatography of the photomixture, the eluting protein fraction was analysed by means of fluorescence spectroscopy. The formation of drug-protein photoadducts could be evidenced by the characteristic emission properties of the carbazole chromophore. The photobinding of the drug to human serum albumin appears to involve the formation of aryl radicals resulting from carbon-halogen photocleavage. This mechanistic interpretation is supported by the observed variations in the intensity of the fluorescence spectra, which can be correlated with the lower quantum yield emission of chlorocarbazoles as compared to non-halogenated analogues. The results from laser flash photolysis studies are also in agreement with this proposal. (C) 2000 Elsevier Science B.V, All rights reserved. Univ Politecn Valencia, CSIC, Inst Tecnol Quim, Dept Quim, E-46071 Valencia, Spain; Unilever Res, Colworth House, SEAC Toxicol Unit, Sharnbrook MK44 1LQ, Beds, England; Univ Valencia, Hosp La Fe, Ctr Invest, E-46009 Valencia, Spain Consejo Superior de Investigaciones Cientificas (CSIC); Universitat Politecnica de Valencia; CSIC-UPV - Instituto de Tecnologia Quimica (ITQ); Unilever; Hospital Universitari i Politecnic La Fe; University of Valencia Miranda, MA (corresponding author), Univ Politecn Valencia, CSIC, Inst Tecnol Quim, Dept Quim, Camino De Vera S-N, E-46071 Valencia, Spain. mmiranda@qim.upv.es Miranda, Miguel A. A/H-6051-2016; Moser, Jill/H-8893-2012; Castell, Jose V/I-9529-2016; Bosca, Francisco/L-2684-2017 Miranda, Miguel A. A/0000-0002-7717-8750; Moser, Jill/0000-0002-9614-2577; Castell, Jose V/0000-0003-1179-6430; Bosca, Francisco/0000-0002-8479-0841 BARRATT MD, 1985, TOXICOL LETT, V24, P1, DOI 10.1016/0378-4274(85)90131-6; Bosca F, 1997, CHEM RES TOXICOL, V10, P820, DOI 10.1021/tx9700376; Bosca F, 1998, J PHOTOCH PHOTOBIO B, V43, P1, DOI 10.1016/S1011-1344(98)00062-1; DEGUIDI G, 1993, J PHOTOCH PHOTOBIO B, V17, P239, DOI 10.1016/1011-1344(93)80021-Z; Encinas S, 1998, CHEM RES TOXICOL, V11, P946, DOI 10.1021/tx9800708; GOH CL, 1986, DERMATOLOGICA, V172, P64, DOI 10.1159/000249297; HOLZLE E, 1991, J AM ACAD DERMATOL, V25, P59, DOI 10.1016/0190-9622(91)70175-2; KOHITA H, 1994, CHEM PHARM BULL, V42, P937; Le Coz CJ, 1998, CONTACT DERMATITIS, V38, P245; LJUNGGREN B, 1985, PHOTODERMATOLOGY, V2, P3; LJUNGGREN B, 1985, PHOTODERMATOLOGY, V2, P377; LOVELL WW, 1993, TOXICOL IN VITRO, V7, P95, DOI 10.1016/0887-2333(93)90117-N; Marguery MC, 1998, REV FR ALLERGOL, V38, P394, DOI 10.1016/S0335-7457(98)80061-0; Miranda MA, 1998, CHEM RES TOXICOL, V11, P172, DOI 10.1021/tx970082d; MIRANDA MA, 1995, TOXICOL IN VITRO, V9, P499, DOI 10.1016/0887-2333(95)00024-3; OPHASWONGSE S, 1993, CONTACT DERMATITIS, V29, P57, DOI 10.1111/j.1600-0536.1993.tb03483.x; PEDERSEN KO, 1962, ARCH BIOCHEM BIOPHYS, P157 17 18 18 0 12 ELSEVIER SCIENCE SA LAUSANNE PO BOX 564, 1001 LAUSANNE, SWITZERLAND 1011-1344 J PHOTOCH PHOTOBIO B J. Photochem. Photobiol. B-Biol. OCT 2000 58 1 13 19 10.1016/S1011-1344(00)00115-9 http://dx.doi.org/10.1016/S1011-1344(00)00115-9 7 Biochemistry & Molecular Biology; Biophysics Science Citation Index Expanded (SCI-EXPANDED) Biochemistry & Molecular Biology; Biophysics 387NV 11195847 2024-02-28 WOS:000166129400004
J Mota, RA; Brito, MF; Castro, FJC; Massa, M Mota, RA; Brito, MF; Castro, FJC; Massa, M Glanders in horses and mules of the states of Pernambuco and Alagoas, Brazil. PESQUISA VETERINARIA BRASILEIRA Portuguese Article glanders; equids; Northeast Brazil Based on clinical-pathological, epidemiological and serological aspects, as well as by the isolation of Burkholderia mallei, foci of glanders were diagnosed in equids of the Zona da Mata" in the states of Pernambuco and Alagoas. Clinically there was hyperthermia, noisy respiration, loss of appetite, progressive loss of weight leading to emaciation, nasal congestion and muco-purulent discharge, erosions, ulcers and scars of the nasal mucosa. The size of submaxillary and cervical lymphonodes was increased, which contained abscesses and fistules exudating purulent material. In the skin, accompanying the lymph vessels, there were firm nodules and abscesses which in chronic cases fistulated and ulcerated leaving stellar scars. The histopathology of the nodules at various sites, from the horses as well as from the guineapigs used for the Strauss test, showed granulomatous lesions and pyogranulomas. The results of this study showed that glanders in the region was emerging and further sero-epidemiological studies are urgent for the eradication of the disease.
