In Utero Alcohol Exposure and the Alteration of Histone Marks in the Developing Fetus: An Epigenetic Phenomenon of Maternal Drinking

被引：20
|
作者：
Mandal, Chanchal [1 ]
Halder, Debasish [1 ]
Jung, Kyoung Hwa [1 ,2 ]
Chai, Young Gyu [1 ,3 ]
机构：
[1] Hanyang Univ, Dept Mol & Life Sci, 1271 Sa Dong, Ansan, South Korea
[2] Hanyang Univ, Inst Nat Sci & Technol, Ansan, South Korea
[3] Hanyang Univ, Dept Bionanotechnol, Seoul, South Korea
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES | 2017年 / 13卷 / 09期
基金：
新加坡国家研究基金会;
关键词：
Alcohol; Teratogenic effects; Epigenetics; FASD; FAS; Histone modifications; CIRCADIAN-RHYTHM DISRUPTION; GENE-EXPRESSION; DNA METHYLATION; TRANSCRIPTION FACTORS; H3; PHOSPHORYLATION; P38; MAPK; ETHANOL; METABOLISM; ACETYLATION; HYPERACETYLATION;
D O I：
10.7150/ijbs.21047
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Ethanol is well known for its teratogenic effects during fetal development. Maternal alcohol consumption allows the developing fetus to experience the detrimental effects of alcohol exposure. Alcohol-mediated teratogenic effects can vary based on the dosage and the length of exposure. The specific mechanism of action behind this teratogenic effect is still unknown. Previous reports demonstrated that alcohol participates in epigenetic alterations, especially histone modifications during fetal development. Additional research is necessary to understand the correlation between major epigenetic events and alcohol-mediated teratogenesis such as that observed in fetal alcohol spectrum disorder (FASD). Here, we attempted to collect all the available information concerning alcohol-mediated histone modifications during gestational fetal development. We hope that this review will aid researchers to further examine the issues associated with ethanol exposure.
引用
收藏
页码：1100 / 1108
页数：9
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