Anti-Inflammatory Effects of Seeds of the Tropical Fruit Camu-Camu (Myrciaria dubia)

被引：24

作者：

Yazawa, Kazunaga ^{[1
]}

Suga, Katsumi ^{[1
]}

Honma, Atsushi ^{[1
,2
]}

Shirosaki, Miyuki ^{[1
]}

Koyama, Tomoyuki ^{[1
]}

机构：

[1] Tokyo Univ Marine Sci & Technol, Grad Sch Marine Sci & Technol, Lab Nutraceut & Funct Foods Sci, Minato Ku, Tokyo 1088477, Japan

[2] Japan Camu Camu Assoc, Ohta Ku, Tokyo 1440052, Japan

来源：

JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY | 2011年 / 57卷 / 01期

关键词：

seed of camu-camu fruit Myrciaria dubia; anti-inflammatory effects in mice; suppressive effect on nitric oxide release; betulinic acid; BETULINIC ACID; LUPANE TRITERPENOIDS; NITRIC-OXIDE; LEAVES; ACTIVATION; INHIBITORS; GLYCOSIDES; ALPHA; RAT; MS;

D O I：

10.3177/jnsv.57.104

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

The methanolic extract of seeds of the tropical fruit camu-camu was screened for its anti-inflammatory activity in carrageenan-induced paw edema model mice. The extract significantly suppressed both the formation of edema in mice by oral administration and the release of nitric oxide from macrophage-derived RAW 264.7 cells in vitro. Based on the results of a spectroscopic analysis. the active compound was identified by in vivo bioassay-guided fractionation to be 3 beta-hydroxy-lup-20(29)-en-28-oic acid, betulinic acid, known as an anti-inflammatory triterpenoid. These findings suggest that camu-camu seed extract is a potentially useful material as a source of betulinic acid and as a functional food for prevention of immune-related diseases.

引用

页码：104 / 107

页数：4

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