Tools for adaptive immune receptor repertoire sequencing

被引：3
|
作者：
Lees, William D. [1 ]
机构：
[1] Birkbeck Coll, Inst Struct & Mol Biol, Malet St, London WC1E 7HX, England
来源：
CURRENT OPINION IN SYSTEMS BIOLOGY | 2020年 / 24卷
关键词：
Antibody repertoire sequencing; Immune receptor genes; AIRR-seq tools; Rep-seq tools; CLONALITY INFERENCE; T-CELL; IMMUNOGLOBULIN;
D O I：
10.1016/j.coisb.2020.10.003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Tools for adaptive immune receptor repertoire (AIRR) sequencing continue to evolve rapidly, and, although some established frameworks are emerging, there are no complete solutions: it is necessary to select tools and build a customised pipeline. Emerging trends of interest include standards for data interchange, tools for single-cell sequencing, genotyping, and tools that make use of probabilistic and structural inferences to identify receptor sequences of interest.
引用
收藏
页码：86 / 92
页数：7
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