Base excision repair genes XRCC1 and APEX1 and the risk for prostate cancer

被引:24
|
作者
Kuasne, H. [1 ,2 ]
Rodrigues, I. S. [2 ]
Losi-Guembarovski, R. [2 ]
Reis, M. B. [2 ]
Fuganti, P. E. [3 ]
Gregorio, E. P. [3 ]
Libos Junior, F. [3 ]
Matsuda, H. M. [2 ]
Rodrigues, M. A. F. [5 ]
Kishima, M. O. [4 ]
Colus, I. M. S. [2 ]
机构
[1] Univ Estadual Londrina UEL, BR-86051990 Londrina, Parana, Brazil
[2] Univ Estadual Londrina, Dept Gen Biol, Ctr Biol Sci, Londrina, PR, Brazil
[3] Londrina Hosp Canc, Londrina, PR, Brazil
[4] Univ Estadual Londrina, Dept Pathol Clin & Toxicol Anal, Hlth Sci Ctr, Londrina, PR, Brazil
[5] Univ Estadual Londrina, Dept Clin Surg, Hlth Sci Ctr, Londrina, PR, Brazil
关键词
Prostate cancer; Polymorphisms; XRCC1; APEX1; Repair genes; ACID SUBSTITUTION VARIANTS; DNA-POLYMERASE BETA; POLYMORPHISMS; MUTATIONS; DAMAGE; ERCC2;
D O I
10.1007/s11033-010-0267-z
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Prostate cancer is the second cause of cancer death in Brazilian men. One of the relevant phenomena to the inherited susceptibility is the presence of allelic variants in genes involved with the DNA repair pathway. The aim of this study was to analyze the frequencies of prevalent, heterozygous and rare genotypes of the base excision repair genes APEX1 and XRCC1 in a case-control study and relate the genotypes with tumoral aggressiveness. DNA from peripheral blood of 172 patients and 172 controls were analyzed by RFLP-PCR method. The polymorphisms were also evaluated in relation to clinical and pathological parameters. The OR (Odds Ratio) and confidence interval (CI = 95%) were used in the association study and the Chi-square and ANOVA tests for the evaluation of histopathological parameters. The rare genotypes frequencies of the gene APEX1 increased the risk for the development of prostate cancer (OR = 1.68 95% CI 1.10-2.58). No association was found for the gene XRCC1 (OR = 0.82 95% CI 0.53-1.27). The combined analysis for both genes did not show association with this neoplasia (OR = 1.27 95% CI 0.79-20.5). The relationship of XRCC1 and APEX1 genotypes with cancer aggressiveness through the correlation with histopathological parameters, did not find any association. Our results suggest that the polymorphism in the gene APEX1 may be indicated as a potential marker for prostate cancer risk.
引用
收藏
页码:1585 / 1591
页数:7
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