Aberrant methylation in promoter-associated CpG islands of multiple genes in acute lymphoblastic leukemia

被引：30
|
作者：
Yang, Y
Takeuchi, S
Hofmann, WK
Ikezoe, T
van Dongen, JJM
Szczepanski, T
Bartram, CR
Yoshino, N
Taguchi, H
Koeffler, HP
机构：
[1] Kochi Med Sch, Dept Med, Kochi 7838505, Japan
[2] Univ Hosp Benjamin Franklin, Charite, Dept Hematol Oncol & Transfus Med, Berlin, Germany
[3] Erasmus Univ, Dept Immunol, Rotterdam, Netherlands
[4] L Warynski Silesian Med Acad, Dept Pediat Hematol & Chemotherapy, Zabrze, Poland
[5] Heidelberg Univ, Inst Human Genet, D-69120 Heidelberg, Germany
[6] Univ Calif Los Angeles, Cedars Sinai Res Inst, Div Hematol Oncol, Sch Med, Los Angeles, CA 90048 USA
来源：
LEUKEMIA RESEARCH | 2006年 / 30卷 / 01期
基金：
美国国家卫生研究院;
关键词：
methylation; multiple genes; ALL;
D O I：
10.1016/j.leukres.2005.06.002
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Methylation profile was analyzed in 10 childhood acute lymphoblastic leukemia (ALL) and nine adult ALL cases. Four genes (p15, p16, RAR beta, FHIT) had methylation in both diseases, four genes (p14, Rb, MLH1, DAPK) showed no methylation in both diseases, and the two genes (APC, RIZ) demonstrated methylation only in adult ALL. Methylation of the RAR beta was more frequent in adult ALL than that in childhood ALL (p=0.01). The number of patients with methylation of multiple genes was higher in adult ALL than that in childhood ALL (p=0.006). Moreover, overall frequency of methylation was higher in adult ALL than that in childhood ALL (p=0.01). (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：98 / 102
页数：5
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