Cardiac MRI biomarkers for Duchenne muscular dystrophy

被引：28

作者：

Magrath, Patrick ^{[1
,2
]}

Maforo, Nyasha ^{[1
,3
]}

Renella, Pierangelo ^{[1
,4
]}

Nelson, Stanley F. ^{[5
]}

Halnon, Nancy ^{[1
,6
]}

Ennis, Daniel B. ^{[1
,2
,3
]}

机构：

[1] Univ Calif Los Angeles, Dept Radiol Sci, Los Angeles, CA 90024 USA

[2] Univ Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, Phys & Biol Med IDP, Los Angeles, CA 90095 USA

[4] CHOC Childrens Hosp, Div Pediat Cardiol, Dept Med, Orange, CA 92868 USA

[5] Univ Calif Los Angeles, Dept Human Genet, Ctr Duchenne Muscular Dystrophy, Los Angeles, CA 90095 USA

[6] Univ Calif Los Angeles, Div Pediat Cardiol, Dept Med, Los Angeles, CA 90024 USA

来源：

BIOMARKERS IN MEDICINE | 2018年 / 12卷 / 11期

关键词：

biomarkers; Duchenne muscular dystrophy; MRI; MITRAL-VALVE-PROLAPSE; HEART-FAILURE; DILATED CARDIOMYOPATHY; CIRCUMFERENTIAL STRAIN; STIMULATED ECHOES; DELAYED ENHANCEMENT; MYOCARDIAL STRAIN; RELAXATION-TIME; CONTRAST UPTAKE; BLOOD-FLOW;

D O I：

10.2217/bmm-2018-0125

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Duchenne muscular dystrophy (DMD) is a fatal inherited genetic disorder that results in progressive muscle weakness and ultimately loss of ambulation, respiratory failure and heart failure. Cardiac MRI (MRI) plays an increasingly important role in the diagnosis and clinical care of boys with DMD and associated cardiomyopathies. Conventional cardiac MRI biomarkers permit measurements of global cardiac function and presence of fibrosis, but changes in these measures are late manifestations. Emerging MRI biomarkers of myocardial function and structure include the estimation of rotational mechanics and regional strain using MRI tagging; T1-mapping; and T2-mapping, a marker of inflammation, edema and fat. These emerging biomarkers provide earlier insights into cardiac involvement in DMD, improving patient care and aiding the evaluation of emerging therapies.

引用

页码：1271 / 1289

页数：19

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