Association between serum lipoprotein levels and neurological function in patients with acute ischemic stroke A protocol of systematic review and meta-analysis

Background: The target of this study is to summarize the association between the serum lipoprotein levels and neurological function in patients with acute ischemic stroke. Methods: A comprehensive search of Cochrane Library, PUBMED, EMBASE, Web of Science, and Chinese Biomedical Literature Database, China National Knowledge Infrastructure from inception to the February 29, 2020 without language and publication date restrictions. All searched studies will be selected by 2 authors independently against the eligibility criteria. Included studies will be critically appraised, and essential data will be extracted by 2 independent authors. If necessary, meta-analysis will be utilized to synthesize the outcome data from included articles. If it is not possible, a narrative synthesis will be undertaken. Results: This study will summarize the up-to-date evidence to investigate the association between serum lipoprotein levels and neurological function in patients with acute ischemic stroke. Conclusion: Its results may present beneficial evidence and guidance for the clinical practice and further studies. Study registration number: INPLASY202040043.