Unusual chromatographic enantioseparation behavior of naproxen on an immobilized polysaccharide-based chiral stationary phase

被引：48
|
作者：
Cui Xiang [1 ,2 ]
Guoqing Liu [1 ,2 ]
Shanshan Kang [1 ,2 ]
Xueping Guo [1 ,2 ]
Bixia Yao [1 ,2 ]
Wen Weng [1 ,2 ]
Qingle Zeng [3 ]
机构：
[1] Zhangzhou Normal Univ, Dept Chem & Environm Sci, Zhangzhou 363000, Peoples R China
[2] Fujian Prov Univ, Key Lab Analyt Sci, Zhangzhou 363000, Peoples R China
[3] Chengdu Univ Technology, Coll Mat & Chem & Chem Engn, Chengdu 610059, Peoples R China
来源：
JOURNAL OF CHROMATOGRAPHY A | 2011年 / 1218卷 / 48期
基金：
中国国家自然科学基金;
关键词：
Enantiomer separation; Chiralpak IA column; Naproxen; Reversal of elution order; Peak deformation; PERFORMANCE LIQUID-CHROMATOGRAPHY; TEMPERATURE-INDUCED INVERSION; ENANTIOMER ELUTION ORDER; VIBRATIONAL CIRCULAR-DICHROISM; ACID ENANTIOMERS; SEPARATION; REVERSAL; CELLULOSE; COLUMN; HPLC;
D O I：
10.1016/j.chroma.2011.10.014
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Enantioseparation of naproxen was performed on an immobilized polysaccharide-based chiral stationary phase (CSP), Chiralpak IA, in the normal-phase mode. The effects of polar alcohol modifier in mobile phase and column temperature on retention, enantioseparation, and elution order were investigated. Two unusual phenomena were observed. One was solvent-induced reversal of elution order for the two enantiomers. Not only the type but also the content of polar alcohol modifier could induce the reversal. Another uncommon phenomenon was peak deformation under some chromatographic conditions. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码：8718 / 8721
页数：4
相关论文
共 50 条
  • [1] Chromatographic Enantioseparation of Chiral Sulfoximines on Polysaccharide-Based Chiral Stationary Phases
    Tang, Qinqin
    Zhao, Ping
    Zeng, Qingle
    [J]. JOURNAL OF CHROMATOGRAPHIC SCIENCE, 2023, 61 (09) : 838 - 843
  • [2] Chromatographic enantioseparation of chiral sulfinamide derivatives on polysaccharide-based chiral stationary phases
    Zeng, Qingle
    Wen, Quan
    Xiang, Yao
    Zhang, Lei
    [J]. JOURNAL OF CHROMATOGRAPHY A, 2018, 1571 : 240 - 244
  • [3] Chromatographic enantioseparations of binaphthyl compounds on an immobilized polysaccharide-based chiral stationary phase
    Weng, Wen
    Guo, Hongxu
    Zhan, Fengping
    Fang, Hongli
    Wang, Qingxiang
    Yao, Bixia
    Li, Shunxing
    [J]. JOURNAL OF CHROMATOGRAPHY A, 2008, 1210 (02) : 178 - 184
  • [4] Enantioseparation of amino acids on a polysaccharide-based chiral stationary phase
    Ye, YK
    Lord, BS
    Yin, L
    Stringham, RW
    [J]. JOURNAL OF CHROMATOGRAPHY A, 2002, 945 (1-2) : 147 - 159
  • [5] Polysaccharide-based chiral stationary phases for high-performance liquid chromatographic enantioseparation
    Yashima, E
    [J]. JOURNAL OF CHROMATOGRAPHY A, 2001, 906 (1-2) : 105 - 125
  • [6] Direct HPLC enantioseparation of chiral aptazepine derivatives on coated and immobilized polysaccharide-based chiral stationary phases
    Cirilli, Roberto
    Orlando, Viviana
    Ferretti, Rosella
    Turchetto, Luciana
    Silvestri, Romano
    De Martino, Gabriella
    La Torre, Francesco
    [J]. CHIRALITY, 2006, 18 (08) : 621 - 632
  • [7] Immobilized Polysaccharide-Based Stationary Phases for Enantioseparation in Normal Versus Reversed Phase HPLC
    Radim Geryk
    Květa Kalíková
    Jiří Vozka
    Eva Tesařová
    [J]. Chromatographia, 2015, 78 : 909 - 915
  • [8] Immobilized Polysaccharide-Based Stationary Phases for Enantioseparation in Normal Versus Reversed Phase HPLC
    Geryk, Radim
    Kalikova, Kveta
    Vozka, Jiri
    Tesarova, Eva
    [J]. CHROMATOGRAPHIA, 2015, 78 (13-14) : 909 - 915
  • [9] Immobilized Polysaccharide-Based Chiral Stationary Phases for HPLC
    Tomoyuki Ikai
    Chiyo Yamamoto
    Masami Kamigaito
    Yoshio Okamoto
    [J]. Polymer Journal, 2006, 38 : 91 - 108
  • [10] Immobilized polysaccharide-based chiral stationary phases for HPLC
    Ikai, T
    Yamamoto, C
    Kamigaito, M
    Okamoto, Y
    [J]. POLYMER JOURNAL, 2006, 38 (02) : 91 - 108
12345