Impact of pathogen-reduction technologies on COVID-19 convalescent plasma potency

被引：14
|
作者：
Focosi, D. [1 ]
Franchini, M. [2 ]
机构：
[1] Pisa Univ Hosp, North Western Tuscany Blood Bank, Via Paradisa 2, I-56124 Pisa, Italy
[2] Carlo Poma Hosp, Dept Hematol & Transfus Med, Mantua, Italy
来源：
TRANSFUSION CLINIQUE ET BIOLOGIQUE | 2021年 / 28卷 / 02期
关键词：
Pathogen inactivation; Pathogen reduction technologies; COVID-19 convalescent plasma; Neutralizing antibodies; Efficacy; IgG subclasses; FRESH-FROZEN PLASMA; ULTRAVIOLET-LIGHT; AMOTOSALEN; RIBOFLAVIN; INACTIVATION;
D O I：
10.1016/j.tracli.2021.02.005
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Pathogen reduction technologies (PRT) have been recommended by many regulatory authorities to minimize the residual risk of transfusion-transmitted infections associated with COVID19 convalescent plasma. While its impact on safety and its cost-effectiveness are nowadays well proven, there is theoretical concern that PRT could impact efficacy of convalescent plasma by altering concentration and/or function of the neutralizing antibodies (nAb). We review here the evidence supporting a lack of significant detrimental effect from PRTs on nAbs. (C) 2021 Societe francaise de transfusion sanguine (SFTS). Published by Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：132 / 134
页数：3
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