Osteochondral regeneration by a bilayered construct in a cell-free or cell-based approach

被引：15

作者：

Cao, Zheng ^{[1
,2
]}

Hou, Shuxun ^{[1
,2
]}

Sun, Daming ^{[1
]}

Wang, Xiaoning ^{[1
]}

Tang, Junjun ^{[1
]}

机构：

[1] Chinese Peoples Liberat Army Gen Hosp, Dept Orthopaed, Affiliated Hosp 1, Beijing 100037, Peoples R China

[2] Chinese Peoples Liberat Army Postgrad Med Sch, Beijing, Peoples R China

来源：

BIOTECHNOLOGY LETTERS | 2012年 / 34卷 / 06期

关键词：

Adipose-derived stem cells; Bilayered scaffold; Cell-based composite; Cell-free composite; Osteochondral regeneration; SCAFFOLD;

D O I：

10.1007/s10529-012-0884-9

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A bilayered construct with or without adipose-derived stem cells (ASCs) was applied to repair full-thickness defects in the patellar groove of 18 rabbits. Non-treated and treated defects were divided into three groups: a control group (n = 12), a cell-free group (n = 12) and a cell-based group (n = 12). Histological appearance and grading were evaluated at 8 and 12 weeks. At 12 weeks, osteochondral-like tissues completely filled in the defects and integrated with host tissues in the cell-based group. The semi-quantitative score of the cell-based group (4.2 +/- A 1.2), which is a total score ranging from 0 (best) to 20 (worst), was significantly better than that of the other two groups (cell-free: 13.8 +/- A 2.5; control: 10.3 +/- A 2.4). This finding indicated that the bilayered constructs combined with ASCs could be an effective way to enhance osteochondral regeneration.

引用

页码：1151 / 1157

页数：7

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