URATE AS A MARKER OF DEVELOPMENT AND PROGRESSION IN PARKINSON'S DISEASE

被引：15
|
作者：
Constantinescu, R. [2 ]
Zetterberg, H. [1 ,3 ]
机构：
[1] Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, S-43180 Molndal, Sweden
[2] Sahlgrens Univ Hosp, Dept Neurol, Gothenburg, Sweden
[3] Sahlgrens Univ Hosp, Clin Neurochem Lab, Molndal, Sweden
来源：
DRUGS OF TODAY | 2011年 / 47卷 / 05期
基金：
瑞典研究理事会;
关键词：
SERUM URIC-ACID; NUTRITION EXAMINATION SURVEY; MILD COGNITIVE IMPAIRMENT; 3RD NATIONAL-HEALTH; PLASMA URATE; L-DOPA; ALZHEIMERS-DISEASE; VASCULAR DEMENTIA; SUBSTANTIA-NIGRA; VITAMIN-C;
D O I：
10.1358/dot.2011.47.5.1591834
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Urate, a natural antioxidant and iron chelator, has emerged as a potentially promising compound that might prevent neurodegenerative disorders. However, hyperuricemia may cause gout and is associated with increased cardiovascular morbidity. This paper summarizes the impact of urate in the context of Parkinson's disease (PD). It reviews the association of serum urate with the risk of PD, the clinical progression in PD, cognitive, dietary and gender aspects, the relationship between gout and PD, and potential therapeutic implications for the future.
引用
收藏
页码：369 / 380
页数：12
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