Genomic analysis of a case of agminated Spitz nevi and congenital-pattern nevi arising in extensive nevus spilus

被引：10

作者：

Porubsky, Caitlin ^{[1
]}

Teer, Jamie K. ^{[2
,3
]}

Zhang, Yonghong ^{[2
]}

Deschaine, Maria ^{[3
]}

Sondak, Vernon K. ^{[4
]}

Messina, Jane L. ^{[3
,4
]}

机构：

[1] PCOM Mednet, Dept Dermatol, North Fulton Hosp Med Campus, Roswell, GA USA

[2] H Lee Moffitt Canc Ctr & Res Inst, Dept Biostat & Bioinformat, Tampa, FL USA

[3] H Lee Moffitt Canc Ctr & Res Inst, Dept Anat Pathol, 12902 Magnolia Dr, Tampa, FL 33612 USA

[4] H Lee Moffitt Canc Ctr & Res Inst, Dept Cutaneous Oncol, Tampa, FL USA

来源：

JOURNAL OF CUTANEOUS PATHOLOGY | 2018年 / 45卷 / 02期

关键词：

congenital nevus; genomics; HRAS; nevus spilus; Spitz nevus; ACTIVATING HRAS MUTATION; MOSAIC RASOPATHIES; MELANOCYTIC NEVUS; SEQUENCING DATA; CODON; 61; NRAS; BRAF;

D O I：

10.1111/cup.13082

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Nevus spilus is a melanocytic neoplasm characterized by a tan macular background punctuated by multiple hyperpigmented macules or papules that represent various types of nevi. These include junctional and compound nevi, Spitz nevi, and rarely blue nevi. We report a unique case of widespread, multiple nevi spili giving rise to agminated Spitz nevi and congenital-pattern compound nevi. We performed genetic analysis to further characterize the mutational profile of this rare entity.

引用

页码：180 / 183

页数：4

共 33 条

[1] Agminated Spitz Nevi Arising on a Nevus Spilus after Chemotherapy
Aida, Khaled
Monia, Kharfi
Ahlem, Sellami
Dominique, Hamel-Teillac
Becima, Fazaa
Sylvie, Fraitag
Ridha, Kamoun Mohamed
[J]. PEDIATRIC DERMATOLOGY, 2010, 27 (04) : 411 - 413
[2] Activating HRAS Mutation in Agminated Spitz Nevi Arising in a Nevus Spilus
Sarin, Kavita Y.
Sun, Bryan K.
Bangs, Charles D.
Cherry, Athena
Swetter, Susan M.
Kim, Jinah
Khavari, Paul A.
[J]. JAMA DERMATOLOGY, 2013, 149 (09) : 1077 - 1080
[3] Agminated Spitz nevi occurring within a congenital speckled lentiginous nevus
Aloi, F
Tomasini, C
Pippione, M
[J]. AMERICAN JOURNAL OF DERMATOPATHOLOGY, 1995, 17 (06) : 594 - 598
[4] Mosaic pathogenic HRAS variant in a patient with nevus spilus with agminated Spitz nevi and parametrial-uterine rhabdomyosarcoma
Nemeth, K.
Szabo, S.
Cottrell, C. E.
McNulty, S. M.
Segura, A.
Sokumbi, O.
Browning, M.
Siegel, D. H.
[J]. BRITISH JOURNAL OF DERMATOLOGY, 2018, 178 (03) : 804 - 806
[5] Agminated intradermal Spitz nevi arising on an unusual speckled lentiginous nevus with localized lentiginosis - A continuum?
Betti, R
Inselvini, E
Palvarini, M
Crosti, C
[J]. AMERICAN JOURNAL OF DERMATOPATHOLOGY, 1997, 19 (05) : 524 - 527
[6] Agminated Spitz Nevi: Case Report and Review of the Literature
Zeng, M. H.
Kong, Q. T.
Sang, H.
Deng, D. Q.
Xie, Q. M.
[J]. PEDIATRIC DERMATOLOGY, 2013, 30 (05) : E104 - E105
[7] A rare case of phakomatosis pigmentokeratotica: Large segmental agminated spitz nevi of the limb associated with speckled lentiginous nevus, together with a giant congenital sebaceous nevus of the head and epidermal nevi of head and neck
Wright, Dakara Rucker
Shwayder, Tor
[J]. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2008, 58 (02) : AB79 - AB79
[8] GIANT NEVUS SPILUS WITH BLUE NEVI - A CASE-REPORT
TOPPE, F
HAAS, N
[J]. ANNALES DE DERMATOLOGIE ET DE VENEREOLOGIE, 1988, 115 (6-7): : 703 - 707
[9] AGMINATED BLUE NEVI ARISING WITHIN A CONGENITAL MELANOCYTIC NEVUS: TREATMENT WITH 755NM ALEXANDRITE LASER
Bradford, Porcia
Petersen, Corbin
Puri, Puja
Burton, Claude
[J]. LASERS IN SURGERY AND MEDICINE, 2011, 43 : 965 - 966
[10] CONGENITAL AGMINATED SPITZ NEVI - IMMUNOREACTIVITY WITH A MELANOMA-ASSOCIATED MONOCLONAL-ANTIBODY
PALAZZO, JP
DURAY, PH
[J]. JOURNAL OF CUTANEOUS PATHOLOGY, 1988, 15 (03) : 166 - 170

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