Stable attachment of the HMB-linker to continuous cellulose membranes for parallel solid phase spot synthesis

被引：40

作者：

VolkmerEngert, R

Hoffmann, B

SchneiderMergener, J

机构：

[1] Inst. für Med. Immunologie, Universitatsklinikum Charite, Humboldt-Universität zu Berlin, D-10098 Berlin

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 06期

关键词：

D O I：

10.1016/S0040-4039(96)02508-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Peptides and other oligomeric molecules were prepared on continuous cellulose membranes using a stably attached p-hydroxymethyl-benzoic acid (HMB)(1) linker. After attachment of N-protected 1,2-epoxy-propylamine to the support via an ether bond, the HMB linker was coupled to this construct resulting in a orthogonal safety-catch linkage suitable for solid phase synthesis. As an application, several peptides, peptoids and carbohydrate-peptide conjugates were prepared and analyzed by HPLC and mass spectrometry. (C) 1997, Elsevier Science Ltd.

引用

页码：1029 / 1032

页数：4

共 20 条

[1] Stable attachment of the HMB-linker to continuous cellulose membranes for parallel solid phase spot synthesis
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Schneider-Mergener, J.
Tetrahedron Letters, 38 (06):
[2] A simple linker for the attachment of aldehydes to the solid phase.: Application to solid phase synthesis by the Multipin™ method
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