Implications of QRS Duration in Dogs With Pacing-Induced Heart Failure

被引:4
|
作者
Wang, Y. [1 ,3 ]
Gong, X. [2 ,3 ]
Su, Y. [2 ,3 ]
Cui, J. [2 ,3 ]
Shu, X. [1 ,2 ,3 ]
机构
[1] Fudan Univ, Zhongshan Hosp, Dept Echocardiog, 180 Fenglin Rd, Shanghai 200032, Peoples R China
[2] Fudan Univ, Zhongshan Hosp, Dept Cardiol, Shanghai 200032, Peoples R China
[3] Shanghai Inst Cardiovasc Dis, Shanghai 200032, Peoples R China
基金
中国国家自然科学基金;
关键词
Echocardiography; Dyssynchrony; Prognosis; Remodeling; LEFT-VENTRICULAR DYSSYNCHRONY; RESYNCHRONIZATION THERAPY; RADIAL STRAIN; CANINE MODEL; SIZE; ECHOCARDIOGRAPHY; CARDIOMYOPATHY; ELECTROCARDIOGRAPHY; ACCURACY; ECG;
D O I
10.33549/physiolres.932152
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
The objective of this study was to find out the implication of QRS duration in dogs with rapid pacing-induced heart failure. Sixteen Beagle dogs were implanted with transvenous cardiac pacemakers and underwent rapid right ventricular pacing for 3 weeks at 260 bpm to induce heart failure. Dogs were divided into two groups according to the QRS duration: 9 with normal QRS duration (<100 ms) and 7 with prolonged QRS duration (>= 100 ms). Cardiac systolic function and size was analyzed by real time 3-dimensional echocardiography and left ventricular dyssynchrony was assessed by speckle tracking strain imaging. Congestive heart failure developed 3 weeks after rapid right ventricular pacing. Dogs with prolonged QRS duration showed more extensive radial strain and circumferential strain dyssynchrony than dogs with normal QRS duration. At the end of 4-week recovery, greater improvement of left ventricular ejection fraction and left ventricular end-systolic volume was detected in dogs with normal QRS duration. The findings suggested that left ventricular dyssynchrony, indicated by a prolonged QRS duration, predicted an unsatisfying recovery in dogs with rapid pacing-induced heart failure. QRS duration had the potential to be a prognostic indicator for dogs with heart failure.
引用
收藏
页码:861 / 868
页数:8
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