Ligands of the peroxisome proliferator-activated receptor-γ and heart failure

被引：3
|
作者：
Thiemermann, C [1 ]
机构：
[1] St Bartholomews & Royal London Sch Med, Dept Expt Med Nephrol & Crit Care, London EC1M 6BQ, England
来源：
BRITISH JOURNAL OF PHARMACOLOGY | 2004年 / 141卷 / 01期
关键词：
PPAR; nuclear-receptors; myocardial infarction; myocardial ischaemia;
D O I：
10.1038/sj.bjp.0705586
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily of ligand-activated transcription factors that are related to retinoid, steroid and thyroid hormone receptors. The PPAR subfamily comprises of three members, PPAR-alpha, PPAR-beta and PPAR-gamma. There is good evidence that ligands of PPAR-gamma, including certain thiazolinediones, reduce myocardial tissue injury and infarct size. The use of PPAR-gamma agonists in the treatment of heart failure is, however, controversial.
引用
收藏
页码：1 / 3
页数：3
相关论文
共 50 条
  • [1] Ligands of the peroxisome proliferator-activated receptor-γ and heart failure (vol 141, pg 1, 2004)
    Thiemermann, C
    BRITISH JOURNAL OF PHARMACOLOGY, 2004, 142 (06) : 1049 - 1051
  • [2] Inflammation in diabetes mellitus:: Role of peroxisome proliferator-activated receptor-α and peroxisome proliferator-activated receptor-γ agonists
    Libby, Peter
    Plutzky, Jorge
    AMERICAN JOURNAL OF CARDIOLOGY, 2007, 99 (4A): : 27B - 40B
  • [3] Peroxisome proliferator-activated receptor-γ ligands inhibit choroidal neovascularization
    Murata, T
    He, SK
    Hangai, M
    Ishibashi, T
    Xi, XP
    Kim, S
    Hsueh, WA
    Ryan, SJ
    Law, RE
    Hinton, DR
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2000, 41 (08) : 2309 - 2317
  • [4] Peroxisome proliferator-activated receptor-γ ligands as investigational modulators of angiogenesis
    Giaginis, Costas
    Margeli, Alexandra
    Theocharis, Stamatios
    EXPERT OPINION ON INVESTIGATIONAL DRUGS, 2007, 16 (10) : 1561 - 1572
  • [5] Peroxisome proliferator-activated receptor-γ and lipodystrophy
    Tantsma, Jouke T.
    Rabelink, Ton J.
    FUTURE LIPIDOLOGY, 2006, 1 (04): : 455 - 462
  • [6] Deactivation of murine alveolar macrophages by peroxisome proliferator-activated receptor-γ ligands
    Reddy, RC
    Keshamouni, VG
    Jaigirdar, SH
    Zeng, XY
    Leff, T
    Thannickal, VJ
    Standiford, TJ
    AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2004, 286 (03) : L613 - L619
  • [7] Peroxisome proliferator-activated receptor-γ ligands as cell-cycle modulators
    Theocharis, S
    Margeli, A
    Vielh, P
    Kouraklis, G
    CANCER TREATMENT REVIEWS, 2004, 30 (06) : 545 - 554
  • [8] Activation of peroxisome proliferator-activated receptor-α and -γ in auricular tissue from heart failure patients
    Gómez-Garre, D
    Herraíz, M
    González-Rubio, ML
    Bernal, R
    Aragoncillo, P
    Carbonell, A
    Rufilanchas, JJ
    Fernández-Cruz, A
    EUROPEAN JOURNAL OF HEART FAILURE, 2006, 8 (02) : 154 - 161
  • [9] Peroxisome proliferator-activated receptor-α -: Friend or foe?
    Yagil, Chana
    Yagil, Yoram
    HYPERTENSION, 2007, 50 (05) : 847 - 850
  • [10] Curcumin is not a ligand for peroxisome proliferator-activated receptor-γ
    Narala, Venkata R.
    Smith, Monica R.
    Adapala, Ravi K.
    Ranga, Rajesh
    Panati, Kalpana
    Moore, Bethany B.
    Leff, Todd
    Reddy, Vudem D.
    Kondapi, Anand K.
    Reddy, Raju C.
    GENE THERAPY AND MOLECULAR BIOLOGY, 2009, 13 (01): : 20 - 25
12345