Amantadine Use Associated with Impulse Control Disorders in Parkinson Disease in Cross-Sectional Study

被引：103
|
作者：
Weintraub, Daniel [1 ,2 ,3 ]
Sohr, Mandy [4 ]
Potenza, Marc N. [5 ,6 ,7 ]
Siderowf, Andrew D. [2 ]
Stacy, Mark [8 ]
Voon, Valerie [9 ]
Whetteckey, Jacqueline [10 ]
Wunderlich, Glen R. [11 ]
Lang, Anthony E. [12 ]
机构：
[1] Univ Penn, Sch Med, Dept Psychiat, Philadelphia, PA 19104 USA
[2] Univ Penn, Sch Med, Dept Neurol, Philadelphia, PA 19104 USA
[3] Philadelphia Vet Affairs Med Ctr, Philadelphia, PA USA
[4] Boehringer Ingelheim Pharma GmbH & Co KG, Ingelheim, Germany
[5] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA
[6] Yale Univ, Sch Med, Dept Child Study, New Haven, CT USA
[7] Yale Univ, Sch Med, Dept Neurobiol, New Haven, CT USA
[8] Duke Univ, Med Ctr, Dept Neurol, Durham, NC USA
[9] Univ Cambridge, Cambridge, England
[10] Boehringer Ingelheim Pharmaceut Inc, Ridgefield, CT 06877 USA
[11] Boehringer Ingelheim Canada Ltd, Burlington, ON, Canada
[12] Univ Toronto, Dept Neurol, Toronto, ON, Canada
来源：
ANNALS OF NEUROLOGY | 2010年 / 68卷 / 06期
关键词：
DYSREGULATION;
D O I：
10.1002/ana.22164
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
A recent controlled clinical vial suggested a role for amantadine as a treatment for pathological gambling in patients with Parkinson disease (PD). Analyzing data from a large cross-sectional study of impulse control disorders (ICDs) in PD, amantadine use (n = 728), vs no amantadine use (n = 2,357), was positively associated with a diagnosis of any ICD (17.6% vs 12.4%, p < 0.001) and compulsive gambling specifically (7.4% vs 4.2%, p < 0.001). This amantadine association remained after controlling for covariates of amantadine use, including both dopamine. agonist use and levodopa dosage. Further research, including larger clinical trials, is needed to assess the role of amantadine in the development and treatment of ICDs in PD. ANN NEUROL 2010;68:963-968
引用
收藏
页码：963 / 968
页数：6
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