Prostate cancer cell adhesion to quiescent endothelial cells is not mediated by beta-1 integrin subunit

被引：0
|
作者：
Cooper, CR [1 ]
Mclean, L [1 ]
Mucci, NR [1 ]
Poncza, P [1 ]
Pienta, KJ [1 ]
机构：
[1] Univ Michigan, Ctr Comprehens Canc, Dept Internal Med, Div Hematol Oncol, Ann Arbor, MI 48109 USA
来源：
ANTICANCER RESEARCH | 2000年 / 20卷 / 6B期
关键词：
cell adhesion molecules; prostate cancer cells; human bone marrow endothelial cells; human aortic endothelial cells; bone metastasis;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background Previous studies have reported that tumor cells' adhesion to quiescent endothelial cells is mediated by beta-1 integrins. The aim of this study was to determine the role beta-1 integrins play in prostate cancer cell adhesion to human bone mal row endothelial cells (HBME) and human aortic endothelial cells (HAEC). Materials and Methods. A well described blocking antibody to beta-1 integrin subunit was used in adhesion assays to determine the role of beta-1 integrin subunit in the adhesion of PC-3 cells to both HBME cells and HAEC. Results Antibody to the beta-1 integrin subunit failed to reduce PC-3 adhesion to HBME and HAEC, yet this same antibody significantly reduced adhesion of PC-3 cells to fibronectin coated wells. Conclusions. The data suggest that metastasis of prostate cancer cells to bone may be mediated, in part, by preferential adhesion to HBME cells; but beta-1 integrins most likely are not involved in this interaction.
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收藏
页码：4159 / 4162
页数：4
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