Synthesis of novel analogues of zanamivir as neuraminidase inhibitors

被引：3

作者：

Xiong, Rui Sheng ^{[1
]}

Zhao, Qing Jie ^{[1
]}

Zhu, Hang Hang ^{[2
]}

Liu, Zheng ^{[3
]}

Wei, Ya Bing ^{[2
]}

Shen, Jing Shan ^{[1
,3
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China

[2] Nanjing Univ Technol, Coll Mat Sci & Engn, Nanjing 210009, Peoples R China

[3] Topharman Shanghai Co Ltd, Shanghai 201209, Peoples R China

来源：

CHINESE CHEMICAL LETTERS | 2010年 / 21卷 / 11期

关键词：

Zanamivir; Triazole; Click chemistry; INFLUENZA-VIRUS NEURAMINIDASE; STRUCTURAL-ANALYSIS; CLICK CHEMISTRY; DESIGN; ACID; DISCOVERY; POTENT; DERIVATIVES; SIALIDASES; SERIES;

D O I：

10.1016/j.cclet.2010.06.021

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A versatile synthesis of novel zanamivir analogues modified at C-4 and C-8 positions was described. The formation of amides from the acid with corresponding amines, followed by click chemistry generated the triazole substituted compounds as novel analogues of neuraminidase inhibitors in good yields. (C) 2010 Jing Shan Shen. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

引用

页码：1338 / 1341

页数：4

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