Exosomal miR-1246 in body fluids is a potential biomarker for gastrointestinal cancer

被引：22
|
作者：
Wei, Chunmeng [1 ]
Li, Yasi [2 ]
Huang, Kaiming [1 ]
Li, Gang [1 ]
He, Min [1 ,3 ]
机构：
[1] Guangxi Med Univ, Sch Publ Hlth, Nanning 530021, Peoples R China
[2] SUNY Stony Brook, Coll Arts & Sci, Stony Brook, NY 11790 USA
[3] Guangxi Med Univ, Minist Educ, Key Lab High Incidence Tumor Prevent & Treatment, Nanning, Peoples R China
来源：
BIOMARKERS IN MEDICINE | 2018年 / 12卷 / 10期
基金：
中国国家自然科学基金;
关键词：
biomarkers; exosome; gastrointestinal cancer; microRNA; miR-1246; SROC; COLORECTAL-CANCER; MICRORNA EXPRESSION; MIRNA EXPRESSION; DOWN-REGULATION; SERUM; METAANALYSIS; METASTASIS; STATISTICS; INVASION; PROTEIN;
D O I：
10.2217/bmm-2017-0440
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The aim was to systematically evaluate whether exosomal miRNAs could be regarded as potential minimally invasive biomarkers of diagnosis for gastrointestinal cancer. Methods: A systematic review and meta analysis of exosomal miRNA expression in gastrointestinal cancer were performed. Results: A total of 370 articles were retrieved from PubMed and EMBASE. The summary receiver operating characteristic curves of three miRNAs (miR-21, miR-1246 and miR-4644) were drawn, miR-21, miR-1246 and miR-4644 exhibited sensitivities of 0.66, 0.920 and 0.750, respectively; specificities were 0.87, 0.958 and 0.769, respectively; and areas under the curve for discriminating gastrointestinal cancer patients from control subjects were 0.876, 0.969 and 0.827, respectively. Conclusion: Exosome miR-1246 had the highest level of diagnostic efficiency, which indicated that miR-1246 could be a biomarker.
引用
收藏
页码：1185 / 1195
页数：11
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