Disease Ontology-based Methods for Disease Similarity Measurement

Disease similarity studies for understanding the pathogenesis of complex diseases, diagnosis, prognosis and drug development are important. Recently, researchers constructed Disease Ontology disease (DO) by integrating a variety of disease terms, which builds up the foundation of disease similarity measurement based on DO. We summary disease similarity calculation methods based on DO-related information in this paper and discuss the issues and challenges in disease similarity measurement, offer helpful reference for further research.