Porous Bioactive Glass Scaffolds for Local Drug Delivery in Osteomyelitis: Development and In Vitro Characterization

被引：52
|
作者：
Soundrapandian, Chidambaram [1 ,2 ]
Datta, Someswar [2 ]
Kundu, Biswanath [2 ]
Basu, Debabrata [2 ]
Sa, Biswanath [1 ]
机构：
[1] Jadavpur Univ, Dept Pharmaceut Technol, Kolkata 700032, India
[2] Cent Glass & Ceram Res Inst, Bioceram & Coating Div, Kolkata 700032, India
来源：
AAPS PHARMSCITECH | 2010年 / 11卷 / 04期
关键词：
bioceramics; bone infection; drug release; organic-inorganic composite; skeletal drug delivery; BIOGLASS SYSTEM; CHITOSAN; HYDROXYAPATITE; ANTIBACTERIAL; MICROSPHERES; ADDITIVES; CERAMICS; IMPLANTS; POROSITY; CAF2;
D O I：
10.1208/s12249-010-9550-5
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
A new bioactive glass-based scaffold was developed for local delivery of drugs in case of osteomyelitis. Bioactive glass having a new composition was prepared and converted into porous scaffold. The bioactivity of the resulting scaffold was examined by in vitro acellular method. The scaffolds were loaded with two different drugs, an antibacterial or antifungal drug. The effects of the size of the scaffold, drug concentration, and dissolution medium on drug release were studied. The scaffolds were further coated with a degradable natural polymer, chitosan, to further control the drug release. Both the glass and scaffold were bioactive. The scaffolds released both the drugs for 6 weeks, in vitro. The results indicated that the bigger the size and the higher the drug concentration, the better was the release profile. The scaffolds appeared to be suitable for local delivery of the drugs in cases of osteomyelitis.
引用
收藏
页码：1675 / 1683
页数：9
相关论文
共 50 条
  • [1] Porous Bioactive Glass Scaffolds for Local Drug Delivery in Osteomyelitis: Development and In Vitro Characterization
    Chidambaram Soundrapandian
    Someswar Datta
    Biswanath Kundu
    Debabrata Basu
    Biswanath Sa
    AAPS PharmSciTech, 2010, 11 : 1675 - 1683
  • [2] Development and effect of different bioactive silicate glass scaffolds: In vitro evaluation for use as a bone drug delivery system
    Department of Pharmaceutics, Himalayan Pharmacy Institute, East Sikkim
    737136, India
    不详
    700032, India
    不详
    700032, India
    J. Mech. Behav. Biomed. Mater., 1 (1-12):
  • [3] Development and effect of different bioactive silicate glass scaffolds: In vitro evaluation for use as a bone drug delivery system
    Soundrapandian, Chidambaram
    Mahato, Arnab
    Kundu, Biswanath
    Datta, Someswar
    Sa, Biswanath
    Basu, Debebrata
    Journal of the Mechanical Behavior of Biomedical Materials, 2014, 40 : 1 - 12
  • [4] Development and effect of different bioactive silicate glass scaffolds: In vitro evaluation for use as a bone drug delivery system
    Soundrapandian, Chidambaram
    Mahato, Arnab
    Kundu, Biswanath
    Datta, Someswar
    Sa, Biswanath
    Basu, Debebrata
    JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, 2014, 40 : 1 - 12
  • [5] The development and characterization of bioactive coatings for local drug delivery in orthopedic applications
    Finsgar, Matjaz
    Kovac, Janez
    Maver, Uros
    PROGRESS IN ORGANIC COATINGS, 2021, 158
  • [6] Local drug delivery system for the treatment of osteomyelitis: In vitro evaluation
    Soundrapandian, Chidambaram
    Basu, Debabrata
    Sa, Biswanath
    Datta, Someswar
    DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2011, 37 (05) : 538 - 546
  • [7] Bioactive borate glass scaffolds: in vitro and in vivo evaluation for use as a drug delivery system in the treatment of bone infection
    Liu, Xin
    Xie, Zongping
    Zhang, Changqing
    Pan, Haobo
    Rahaman, Mohamed N.
    Zhang, Xin
    Fu, Qiang
    Huang, Wenhai
    JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 2010, 21 (02) : 575 - 582
  • [8] Preparation, physicochemical properties and in vitro bioactivity of hierarchically porous bioactive glass scaffolds
    Wang, Xiaocheng
    Shi, Mengchao
    Zhai, Dong
    Wu, Chengtie
    RSC ADVANCES, 2015, 5 (120): : 98796 - 98804
  • [9] Bioactive borate glass scaffolds: in vitro and in vivo evaluation for use as a drug delivery system in the treatment of bone infection
    Xin Liu
    Zongping Xie
    Changqing Zhang
    Haobo Pan
    Mohamed N. Rahaman
    Xin Zhang
    Qiang Fu
    Wenhai Huang
    Journal of Materials Science: Materials in Medicine, 2010, 21 : 575 - 582
  • [10] Fabrication and in vitro characterization of bioactive glass composite scaffolds for bone regeneration
    Poh, Patrina S. P.
    Hutmacher, Dietmar W.
    Stevens, Molly M.
    Woodruff, Maria A.
    BIOFABRICATION, 2013, 5 (04)
12345