Availability of clean, safe drinking water is one of the primary needs of human beings. The present study focused on the quality of drinking water in Alappuzha district, in the state of Kerala, India. The harmful concentrations of water-soluble chemicals in drinking water can adversely affect human health. This investigation probed the influence of toxic chemical pollutants on human health. Although concentrations of chemical parameters in the water samples were found to be within the permissible limits, cases of humans infected by waterborne disease such as Leptospirosis, Hepatitis A, and Hepatitis E, Cholera, Shigellosis, and Amoebic meningoencephalitis were reported in the district, in the year 2016. This suggests that microorganisms play a vital role in contaminating water and spreading disease. As many of these diseases are lethal, expedient remedial measures must be undertaken to alleviate their incidence and severity. (c) 2020 Elsevier Ltd. All rights reserved. Selection and peer-review under responsibility of the scientific committee of the International Conference on Advances in Material Science and Chemistry-2020.