Pharmacogenetic Testing: Time for Clinical Practice Guidelines

被引：35
|
作者：
Amstutz, U. [1 ,2 ,3 ]
Carleton, B. C. [1 ,2 ,3 ]
机构：
[1] Univ British Columbia, Dept Pediat, Fac Med, Vancouver, BC V6T 1W5, Canada
[2] BC Childrens Hosp, Pharmaceut Outcomes Programme, Vancouver, BC, Canada
[3] Child & Family Res Inst, Vancouver, BC, Canada
来源：
CLINICAL PHARMACOLOGY & THERAPEUTICS | 2011年 / 89卷 / 06期
关键词：
BREAST-CANCER RECURRENCE; CONCURRENT USE; TAMOXIFEN; THERAPY; UPDATE; CYP2D6; WOMEN;
D O I：
10.1038/clpt.2011.18
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Our knowledge regarding genetic factors that affect drug effectiveness and adverse drug reactions is continuously increasing, and a growing number of pharmacogenetic gene-drug interactions are included in drug labels. Nevertheless, the uptake of this important information into clinical practice has been minimal. The development of concise, evidence-based clinical practice guidelines (CPGs) on pharmacogenetic testing is urgently needed to overcome the barriers hindering clinical implementation by providing guidance on test use and interpretation.
引用
收藏
页码：924 / 927
页数：4
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