Differential effects of neurotoxin-induced lesions of the basolateral amygdala and central nucleus of the amygdala on lithium-induced conditioned disgust reactions and conditioned taste avoidance

被引：23
|
作者：
Rana, Shadna A. [2 ]
Parker, Linda A. [1 ]
机构：
[1] Univ Guelph, Dept Psychol, Guelph, ON N1H 2W1, Canada
[2] Wilfrid Laurier Univ, Dept Psychol, Waterloo, ON N2L 3C5, Canada
来源：
BEHAVIOURAL BRAIN RESEARCH | 2008年 / 189卷 / 02期
基金：
加拿大自然科学与工程研究理事会;
关键词：
conditioned disgust; taste avoidance; taste reactivity; lithium; illness; nausea; fear; neurotoxin; lesion; amygdala;
D O I：
10.1016/j.bbr.2008.01.005
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
When rats are intraorally exposed to saccharin solution that has previously been paired with lithium chloride (LiCl), they display Pavlovian conditioned disgust reactions. When exposed to LiCl-paired saccharin solution by bottle, they display suppressed instrumental approach to the bottle resulting in suppressed consumption. The present experiments demonstrated that while neither neurotoxin-induced lesions of the basolateral amygdala (BLA) nor the central nucleus of the amygdala (CeA) attenuated the display of Pavlovian conditioned disgust reactions, lesions of the BLA (but not the CeA) attenuated instrumental conditioned avoidance of the taste. The results are discussed in light of current models of the role of the amygdala in aversive learning. (C) 2008 Elsevier B.V. All rights reserved.
引用
收藏
页码：284 / 297
页数：14
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共 49 条
  • [1] Effects of central and basolateral amygdala lesions on conditioned taste aversion and latent inhibition
    Andre, Justin St.
    Reilly, Steve
    [J]. BEHAVIORAL NEUROSCIENCE, 2007, 121 (01) : 90 - 99
  • [2] The antiemetic drug ondansetron interferes with lithium-induced conditioned rejection reactions, but not lithium-induced taste avoidance in rats
    Limebeer, CL
    Parker, LA
    [J]. JOURNAL OF EXPERIMENTAL PSYCHOLOGY-ANIMAL BEHAVIORAL PROCESSES, 2000, 26 (04): : 371 - 384
  • [3] EFFECTS OF LESIONS OF THE BASOLATERAL AND LATERAL AMYGDALA ON NEOPHOBIA AND CONDITIONED TASTE-AVERSION IN RATS
    KOLAKOWSKA, L
    LARUEACHAGIOTIS, C
    LEMAGNEN, J
    [J]. PHYSIOLOGY & BEHAVIOR, 1984, 32 (04) : 647 - 651
  • [4] Dissociation of conditioned taste avoidance from conditioned disgust reactions induced by wheel running in rats
    Grant, Virginia L.
    McDonald, Sarah V.
    Sheppard, Robyn C.
    Caldwell, Catherine L.
    Heeley, Thomas H.
    Brown, Adam R.
    Martin, Gerard M.
    [J]. BEHAVIOURAL PROCESSES, 2012, 90 (02) : 223 - 228
  • [5] The basolateral nucleus of the amygdala executes the parallel processes of avoidance and palatability in the retrieval of conditioned taste aversion in male rats
    Inui, Tadashi
    Sugishita, Tomoaki
    Inui-Yamamoto, Chizuko
    Yasoshima, Yasunobu
    Shimura, Tsuyoshi
    [J]. ENEURO, 2019, 6 (04) : 1 - 16
  • [6] A Comparison Between Taste Avoidance and Conditioned Disgust Reactions Induced by Ethanol and Lithium Chloride in Preweanling Rats
    Arias, Carlos
    Marcos Pautassi, Ricardo
    Carlos Molina, Juan
    Spear, Norman E.
    [J]. DEVELOPMENTAL PSYCHOBIOLOGY, 2010, 52 (06) : 545 - 557
  • [7] DIFFERENTIAL-EFFECTS OF EXCITOTOXIC LESIONS OF THE AMYGDALA ON COCAINE-INDUCED CONDITIONED LOCOMOTION AND CONDITIONED PLACE PREFERENCE
    BROWN, EE
    FIBIGER, HC
    [J]. PSYCHOPHARMACOLOGY, 1993, 113 (01) : 123 - 130
  • [8] Effects of central and basolateral amygdala lesions on conditioned taste aversion and latent inhibition (vol 121, pg 80, 2007)
    Andre, Justin St.
    Reilly, Steve
    [J]. BEHAVIORAL NEUROSCIENCE, 2007, 121 (06) : 1363 - 1363
  • [9] 5,7-dihydroxytryptamine lesions of the dorsal and median raphe nuclei interfere with lithium-induced conditioned gaping, but not conditioned taste avoidance, in rats
    Limebeer, CL
    Parker, LA
    Fletcher, PJ
    [J]. BEHAVIORAL NEUROSCIENCE, 2004, 118 (06) : 1391 - 1399
  • [10] Effects of excitotoxic lesions of the central or basolateral nucleus of the amygdala on naloxone-precipitated withdrawal-induced conditioned place aversion in morphine-dependent rats
    Watanabe, T
    Yamamoto, R
    Maeda, A
    Nakagawa, T
    Minami, M
    Satoh, M
    [J]. BRAIN RESEARCH, 2002, 958 (02) : 423 - 428
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