Dietary Nutrients and Prevention of Alzheimer's Disease

被引:13
|
作者
Chauhan, Pallavi Singh [1 ]
Yadav, Dhananjay [2 ]
Arukha, Ananta Prasad [3 ]
机构
[1] Amity Univ Madhya Pradesh, Amity Inst Biotechnol, Gwalior, MP, India
[2] Yeungnam Univ, Dept Med Biotechnol, Room 225-1, Gyongsan 38541, South Korea
[3] Univ Florida, Coll Vet Med, Gainesville, FL USA
基金
新加坡国家研究基金会;
关键词
Alzheimer's Disease; nutrition; oxidative stress; neurodegeneration; inflammation; brain disease; ANTIOXIDANT ACTIVITY; OXIDATIVE STRESS; MEDITERRANEAN DIET; ER STRESS; HEALTH; APOPTOSIS; IMPROVES; RISK;
D O I
10.2174/1871527320666210405141123
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Alzheimer's disease is an irrevocable, progressive brain disorder that gradually destroys memory and cognitive skills. One of the extensively studied methods of preventing Alzheimer's disease (AD) progression is by providing a nutritional diet. Several reports have shown that intake of nutritional elements as huperzine A, ursolic acid, vitamins etc., can directly influence pathogenesis of AD. Surprisingly, the occurrence of metabolic disorders due to an unhealthy diet has been known to be a major environmental cause of AD. It has been noted that AD severity can be controlled by supplementing dietary supplements containing huge amounts of health-promoting ingredients. These elements promote cell health, regeneration, and the anti-aging process that specifically interrupt the pathogenic pathways in AD development. Fortunately, incorporating changes in the nutritional content is inexpensive, easy, acceptable, safe, effective, and in most cases, free from major adverse events. Many nutritional phytoconstituents such as flavonoids, alkaloids, and terpenoids are still being evaluated in the hope of identifying a successful therapy for AD. This review discusses the therapeutical potential of several key nutrients that have been researched for treating AD treatment and the method of their neuroprotective intervention.
引用
收藏
页码:217 / 227
页数:11
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