Objective: Acute appendicitis (AA) is the most non-traumatic acute abdominal inducement. Even if negative appendectomy rates tend to go down due to technological diagnostic procedures, scoring systems still have importance in the diagnosis of AA because they are easily accessible, cheap and practicable in all the health centers. Design: A retrospective study Setting: Kafkas University School of Medicine, Turkey and Kars State Hospital, Turkey Subjects: Three hundred and thirteen patients who had undergone immediate surgery with the pre-diagnosis of AA participated in this study between January 2013 and June 2015. Interventions: Modified Alvarado Scoring System (MASS), Eskelinen Scoring System (ESS) and Ohmann Scoring System (OSS) were calculated and results compared with positive-negative appendectomy groups using inspected parameters and symptoms. The data analysis was made via a packet program of SPSS for Windows version 22 (Chicago, IL, USA). Main outcome measures: We compared the effectiveness of the MASS, ESS and OSS, and their effects on decreasing negative appendectomy rates in the diagnosis of AA for patients operated on following a pre-diagnosis of AA. Results: Age and gender distribution of positive appendectomy group (PAG) and negative appendectomy groups (NAG) were homogeneous (p: 0.206 and p: 0.896). Eskelinen score (ES), MASS and OS were statistically high in PAG (p: 0.049, p < 0.001 and p: 0.003). Conclusion: MASS, ES and OS are considered as easy, low-cost, quick and applicable methods in all health centers if a sufficient number of patients are taken into consideration.