Revolutionizing technologies of nanomicelles for combinatorial anticancer drug delivery

被引：22

作者：

Jo, Min Jeong ^{[1
]}

Jin, Ik Sup ^{[1
]}

Park, Chun-Woong ^{[1
]}

Hwang, Bang Yeon ^{[1
]}

Chung, Youn Bok ^{[1
]}

Kim, Jin-Seok ^{[2
]}

Shin, Dae Hwan ^{[1
]}

机构：

[1] Chungbuk Natl Univ, Coll Pharm, Osongsaengmyeong 1 Ro, Osong Eup 28160, Cheongju, South Korea

[2] Sookmyung Womens Univ, Coll Pharm, DIRI, Cheongpa Ro 47 Gil 100, Seoul 04310, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2020年 / 43卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

Nanotechnology; Drug combination; Micelles; Anticancer drugs; Solubilization; SMALL-CELL-CARCINOMA; LINES IN-VITRO; SYNERGISTIC CYTOTOXICITY; INDUCED APOPTOSIS; CREMOPHOR-FREE; SINGLE-AGENT; GENEXOL-PM; CANCER; PACLITAXEL; CHEMOTHERAPY;

D O I：

10.1007/s12272-020-01215-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Insufficient efficacy of current single drug therapy of cancers have led to the advancement of combination drug-loaded formulations. Specifically, polymeric micelles have been focused on as efficient injectable vehicles for the delivery of several anticancer drugs simultaneously to cancer cells. These nano delivery systems have evolved with advancements in the area of nanotechnology. The current review presents a summary of the past events that have led to the procession of nanomicelles and novel nanotechnologies for combinatorial drug delivery. It also focuses on the advantages, disadvantages, and considerations for the design of nanotechnologies for combinatorial drug delivery systems. The opportunities and challenges of nanotechnologies in drug delivery to overcome current disadvantages are also discussed. Furthermore, we have added findings regarding the trends and perspectives regarding nanotechnologies for combinatorial anticancer drug delivery.

引用

页码：100 / 109

页数：10

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