Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

被引：2949

作者：

Blanco-Melo, Daniel ^{[1
,2
]}

Nilsson-Payant, Benjamin E. ^{[1
,2
]}

Liu, Wen-Chun ^{[1
,3
]}

Uhl, Skyler ^{[1
,2
]}

Hoagland, Daisy ^{[1
,2
]}

Moller, Rasmus ^{[1
,2
]}

Jordan, Tristan X. ^{[1
,2
]}

Oishi, Kohei ^{[1
,2
]}

Panis, Maryline ^{[1
,2
]}

Sachs, David ^{[4
]}

Wang, Taia T. ^{[5
,6
,7
]}

Schwartz, Robert E. ^{[8
]}

Lim, Jean K. ^{[1
]}

Albrecht, Randy A. ^{[1
,3
]}

tenOever, Benjamin R. ^{[1
,2
,3
]}

机构：

[1] Icahn Sch Med Mt Sinai, Dept Microbiol, New York, NY 10029 USA

[2] Icahn Sch Med Mt Sinai, Virus Engn Ctr Therapeut & Res, New York, NY 10029 USA

[3] Icahn Sch Med Mt Sinai, Global Hlth & Emerging Pathogens Inst, New York, NY 10029 USA

[4] Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY 10029 USA

[5] Stanford Univ, Dept Med, Sch Med, Div Infect Dis, Stanford, CA 94305 USA

[6] Stanford Univ, Dept Microbiol & Immunol, Sch Med, Stanford, CA 94305 USA

[7] Chan Zuckerberg Biohub, San Francisco, CA USA

[8] Weill Cornell Med, Div Gastroenterol & Hepatol, Dept Med, New York, NY 10065 USA

来源：

CELL | 2020年 / 181卷 / 05期

基金：

美国国家卫生研究院;

关键词：

INTERFERON; CORONAVIRUS; SARS; TRANSMISSION; PATHOGENESIS; INFECTION; PROTEIN; CELLS;

D O I：

10.1016/j.cell.2020.04.026

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Viral pandemics, such as the one caused by SARS-CoV-2, pose an imminent threat to humanity. Because of its recent emergence, there is a paucity of information regarding viral behavior and host response following SARS-CoV-2 infection. Here we offer an in-depth analysis of the transcriptional response to SARS-CoV-2 compared with other respiratory viruses. Cell and animal models of SARS-CoV-2 infection, in addition to transcriptional and serum profiling of COVID-19 patients, consistently revealed a unique and inappropriate inflammatory response. This response is defined by low levels of type I and III interferons juxtaposed to elevated chemokines and high expression of IL-6. Wepropose that reduced innate antiviral defenses coupled with exuberant inflammatory cytokine production are the defining and driving features of COVID-19.

引用

页码：1036 / +

页数：19

共 50 条

[1] Host transcriptional response to SARS-CoV-2 infection in COVID-19 patients
Singh, Nitesh Kumar
Srivastava, Surabhi
Zaveri, Lamuk
Bingi, Thrilok Chander
Mesipogu, Rajarao
Kumar, Santosh, V
Gaur, Namami
Hajirnis, Nikhil
Machha, Pratheusa
Shambhavi, Sakshi
Khan, Shagufta
Soujanya, Mamilla
Nagabandi, Tulasi
Mishra, Rakesh K.
Tallapaka, Karthik Bharadwaj
Sowpati, Divya Tej
CLINICAL AND TRANSLATIONAL MEDICINE, 2021, 11 (09):
[2] Research Response to SARS-CoV-2/COVID-19
Burger, Charles D. y
Mikhail, Amanda E.
Orenstein, Robert
Ebbert, Jon O.
Vergidis, Paschalis
Badley, Andrew D.
MAYO CLINIC PROCEEDINGS, 2020, 95 (09) : S52 - S55
[3] SARS-CoV-2 and COVID-19
Sheng, Wang-Huei
Ko, Wen-Chien
Huang, Yhu-Chering
Hsueh, Po-Ren
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION, 2020, 53 (03) : 363 - 364
[4] The role of host genetics in the immune response to SARS-CoV-2 and COVID-19 susceptibility and severity
Ovsyannikova, Inna G.
Haralambieva, Iana H.
Crooke, Stephen N.
Poland, Gregory A.
Kennedy, Richard B.
IMMUNOLOGICAL REVIEWS, 2020, 296 (01) : 205 - 219
[5] Implications of the Immune Polymorphisms of the Host and the Genetic Variability of SARS-CoV-2 in the Development of COVID-19
Zepeda-Cervantes, Jesus
Martinez-Flores, Daniel
Ramirez-Jarquin, Josue Orlando
Tecalco-Cruz, angeles C.
Alavez-Perez, Noe Santiago
Vaca, Luis
Sarmiento-Silva, Rosa Elena
VIRUSES-BASEL, 2022, 14 (01):
[6] Focus on SARS-CoV-2 and COVID-19
Chen, Sharon C-A.
Rawlinson, William D.
PATHOLOGY, 2020, 52 (07) : 743 - 744
[7] SARS-CoV-2 and the pandemic of COVID-19
Adil, Md Tanveer
Rahman, Rumana
Whitelaw, Douglas
Jain, Vigyan
Al-Taan, Omer
Rashid, Farhan
Munasinghe, Aruna
Jambulingam, Periyathambi
POSTGRADUATE MEDICAL JOURNAL, 2021, 97 (1144) : 110 - 116
[8] Coronavirus, COVID-19 and SARS-CoV-2
Megias, Jorge
REVISTA HISPANOAMERICANA DE HERNIA, 2020, 8 (02) : 111 - 111
[9] Characteristics of SARS-CoV-2 and COVID-19
Ben Hu
Hua Guo
Peng Zhou
Zheng-Li Shi
Nature Reviews Microbiology, 2021, 19 : 141 - 154
[10] Dementia and SARS-Cov-2/COVID-19
Zieschang, T.
ZEITSCHRIFT FUR GERONTOLOGIE UND GERIATRIE, 2021, 54 (SUPPL 1): : S14 - S14

← 1 2 3 4 5 →